The Genetic Understanding of Asbestos related disorders (GUARD)

该提案旨在建立一个新的间皮瘤研究国家生物医学资源，通过系统地使世界级的遗传流行病学研究资源成为可能，从而巩固和加强澳大利亚的国家卫生和医学研究工作。石棉相关疾病的遗传学理解（GUARD）项目旨在建立一个国家设施，使恶性间皮瘤（MM）和其他石棉相关疾病的新的，大规模的DNA库能力。GUARD生物标本资源和链接数据库将整合目前基于西澳人口的石棉暴露队列与来自澳大利亚各地的病例收集。GUARD项目将进行高质量的研究，旨在发现基因和基因：间皮瘤化疗的易感性，进展和可变反应的基础环境相互作用，并将促进遗传流行病学和药物基因组学领域的国家合作和研究。GUARD项目目标的进展可能带来巨大的公共卫生效益;由于石棉暴露和诊断之间的长期延迟，恶性黑色素瘤的发病率正在增加。GUARD将确保澳大利亚研究人员能够获得与优秀临床数据相关的大量管理良好的生物标本资源，并确保澳大利亚在间皮瘤遗传研究方面发挥国际领先作用。GUARD数据对于了解特定基因在澳大利亚普通人群中的重要性和功能作用以及它们与特定环境因素的关系至关重要。了解因果因素如何在人群水平上起作用将是临床利用新的基因组知识和工具来改善临床实践和公共卫生的关键一步。

This proposal is to build a new national biospeciman resource for mesothelioma research that will both underpin and enhance the national health and medical research effort in Australia by systematically enabling a world-class resource for genetic epidemiological research. The Genetic Understanding of Asbestos-Related Disorders (GUARD) project aims to establish a national facility that will enable new, large-scale DNA banking capacity for malignant mesothelioma (MM) and other asbestos-related diseases. The GUARD biospecimen resource and linked database will integrate the current WA population-based asbestos-exposed cohorts with case collections from across Australia. The GUARD project will undertake high-quality research aimed at discovering the genes and gene: environment interactions underlying susceptibility, progression and variable response to chemotherapy in mesothelioma, and will facilitate National collaboration and research in the areas of genetic epidemiology and pharmacogenomics. Progress towards the goals of the GUARD project holds the potential for enormous public health benefits; the incidence of malignant melanoma is increasing, due to the long delay between asbestos exposure and diagnosis. GUARD will ensure that Australian researchers have access to a large and well-managed biospecimen resource linked to excellent clinical data, and that Australia takes the lead role internationally in genetic research into mesothelioma. GUARD data will be critical for understanding the importance and functional roles of specific genes in the general Australian population, and their relationship to particular environmental factors. Understanding how causal factors act at a population level will be a critical step for the clinical utilization of new genomic knowledge and tools to improve clinical practice and public health.