Genetic and Environmental Origins of the Development of Pain in Children

儿童疼痛发展的遗传和环境根源

• 批准号: 9322324
• 负责人: Mary Colleen Davis
• 金额: $ 59.92万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9322324
• 关键词: 11 year old; Address; Adult; Alcohol or Other Drugs use; Anxiety; Arizona; Behavioral; Behavioral Genetics; Birth Records; Brain; Child; Child Development; Child Rearing; Childhood; Code; Communities; Comorbidity; Conflict (Psychology); Data; Databases; Demographic Factors; Development; Discipline of obstetrics; Disease susceptibility; Emotions; Environment; Environmental Risk Factor; Epidemiology; Ethnic Origin; Etiology; Family; Family Relationship; Fathers; Frequencies; Future; Generations; Genes; Genetic; Genetic Models; Genetic study; Growth; Habits; Health; Health Psychology; Health behavior; Heritability; Home environment; Hydrocortisone; Hyperactive behavior; Interdisciplinary Study; Light; Link; Maintenance; Measures; Mediating; Medical Records; Mental Depression; Mental Health; Methodology; Methods; Modeling; Mood Disorders; Moods; Mothers; Pain; Pain Measurement; Pain Research; Parents; Persons; Phenotype; Physiological; Prevalence; Prevention; Preventive Intervention; Process; Psychometrics; Psychosocial Factor; Recurrence; Reporting; Research; Research Project Grants; Risk; Risk Factors; Role; Running; Sample Size; Sampling; Sleep; Socioeconomic Status; Specificity; Substance abuse problem; Symptoms; Syndrome; Testing; Time; Treatment Efficacy; Twin Multiple Birth; Youth; base; behavior observation; chronic pain; clinical phenotype; conduct problem; coping; critical developmental period; daily functioning; design; diet and exercise; disability; early adolescence; early childhood; ethnic diversity; executive function; inattention; infancy; intergenerational; neonatal morbidity; novel; offspring; physical conditioning; positive emotional state; prenatal; prevent; programs; public health relevance; resilience; sex; theories; therapy design; transmission process

Project Description The proposed interdisciplinary research project is the first to bridge the theoretical and methodological gaps between pediatric health psychology and behavior genetics to significantly advance our understanding of children's pain. The body of research examining childhood pain points to the likelihood that multiple genetic and environmental factors underlie the development and maintenance of chronic pain in children. Critical questions need to be addressed before efforts at prevention and intervention can have maximum impact. The four aims address four key questions for the field of pain research: 1) genetic and environmental etiology of pain, 2) transmission of pain across generations, 3) the role of environmental risk and protective factors in pain, and in moderating the heritability of pain, and 4) the growth in pain, including the bidirectional relations between pain and general dysregulation across development. Chronic pain is often comorbid with mood disorders, and we examine the extent to which pain and mood, behavioral and physiological dysregulation share a common etiology. To accomplish our aims, we propose to conduct longitudinal follow ups (9, 10 and 11 years of age) of a birth-records-based community sample of 350 pairs of ethnically diverse twin children. Early risk and resilient aspects of the environment have already been well-characterized, including obstetrical complications and neonatal morbidity coded from medical records, and early parenting. The multi-method approach includes objective assessments of pain frequency, intensity, duration, and disability in twin children and their mothers and fathers. Combining these design features exponentially increases the scientific contribution by elucidating processes that will support preventive intervention efforts.

项目说明 拟议的跨学科研究项目是第一个弥合理论和方法差距的项目。 儿童健康心理学和行为遗传学之间的关系，以显著促进我们对 孩子们的痛苦。检查儿童疼痛的研究机构指出，多基因可能 环境因素是儿童慢性疼痛的发展和维持的基础。批判性 在预防和干预努力能够产生最大影响之前，需要解决这些问题。这个 四个目标解决疼痛研究领域的四个关键问题：1)遗传和环境病因学 疼痛，2)疼痛的世代传播，3)环境风险和保护因素在 疼痛，以及调节疼痛的遗传性，以及4)疼痛的增长，包括双向关系 在疼痛和整个发育过程中的普遍失调之间。慢性疼痛常常伴随着情绪。 紊乱，我们检查疼痛和情绪，行为和生理失调的程度 有共同的病因。为了达到我们的目标，我们建议进行纵向跟踪(9、10和 11岁)，这是一个基于出生记录的社区样本，包括350对不同种族的双胞胎孩子。 环境的早期风险和弹性方面已经有了很好的特征，包括产科 从医疗记录中编码的并发症和新生儿发病率，以及早期养育。多方法 方法包括对双胞胎儿童疼痛频率、强度、持续时间和残疾的客观评估。 以及他们的父母。将这些设计功能结合在一起，可以指数级地增加科学 通过阐明支持预防性干预工作的程序作出贡献。