Genetic and Environmental Origins of the Development of Pain in Children

儿童疼痛发展的遗传和环境根源

• 批准号: 9175111
• 负责人: Mary Colleen Davis
• 金额: $ 61.54万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9175111
• 关键词: 11 year old; Address; Adult; Alcohol or Other Drugs use; Arizona; Behavioral; Behavioral Genetics; Birth Records; Brain; Child; Child Development; Child Rearing; Childhood; Code; Communities; Conflict (Psychology); Data; Databases; Demographic Factors; Development; Disease susceptibility; Emotions; Environment; Environmental Risk Factor; Epidemiology; Ethnic Origin; Etiology; Family; Family Relationship; Fathers; Frequencies; Future; Generations; Genes; Genetic; Genetic Models; Genetic study; Growth; Habits; Health; Health Psychology; Health behavior; Heritability; Home environment; Hydrocortisone; Hyperactive behavior; Interdisciplinary Study; Light; Link; Maintenance; Measures; Mediating; Medical Records; Mental Depression; Mental Health; Methods; Modeling; Mood Disorders; Moods; Mothers; Pain; Pain Measurement; Pain Research; Pain Threshold; Parents; Persons; Phenotype; Physiological; Prevalence; Prevention; Preventive Intervention; Process; Psychometrics; Psychosocial Factor; Recurrence; Reporting; Research; Research Project Grants; Risk; Risk Factors; Role; Running; Sample Size; Sampling; Shapes; Sleep; Socioeconomic Status; Specificity; Substance abuse problem; Symptoms; Syndrome; Testing; Time; Twin Multiple Birth; Youth; anxiety symptoms; base; behavior observation; chronic pain; conduct problem; coping; critical developmental period; daily functioning; design; diet and exercise; disability; early adolescence; early childhood; ethnic diversity; executive function; inattention; infancy; intergenerational; neonatal morbidity; novel; offspring; physical conditioning; positive emotional state; prenatal; prevent; programs; public health relevance; resilience; sex; theories; therapy design; transmission process

Project Description The proposed interdisciplinary research project is the first to bridge the theoretical and methodological gaps between pediatric health psychology and behavior genetics to significantly advance our understanding of children's pain. The body of research examining childhood pain points to the likelihood that multiple genetic and environmental factors underlie the development and maintenance of chronic pain in children. Critical questions need to be addressed before efforts at prevention and intervention can have maximum impact. The four aims address four key questions for the field of pain research: 1) genetic and environmental etiology of pain, 2) transmission of pain across generations, 3) the role of environmental risk and protective factors in pain, and in moderating the heritability of pain, and 4) the growth in pain, including the bidirectional relations between pain and general dysregulation across development. Chronic pain is often comorbid with mood disorders, and we examine the extent to which pain and mood, behavioral and physiological dysregulation share a common etiology. To accomplish our aims, we propose to conduct longitudinal follow ups (9, 10 and 11 years of age) of a birth-records-based community sample of 350 pairs of ethnically diverse twin children. Early risk and resilient aspects of the environment have already been well-characterized, including obstetrical complications and neonatal morbidity coded from medical records, and early parenting. The multi-method approach includes objective assessments of pain frequency, intensity, duration, and disability in twin children and their mothers and fathers. Combining these design features exponentially increases the scientific contribution by elucidating processes that will support preventive intervention efforts.

项目描述 拟议的跨学科研究项目是第一个弥合理论和方法论差距的项目 儿科健康心理学和行为遗传学之间的关系，以显着增进我们的理解 儿童的痛苦。研究儿童期疼痛的研究表明，多种遗传因素可能 环境因素是儿童慢性疼痛发生和维持的基础。批判的 在预防和干预工作能够产生最大影响之前，需要解决一些问题。这 四个目标解决了疼痛研究领域的四个关键问题：1）遗传和环境病因学 疼痛，2) 疼痛的代际传递，3) 环境风险和保护因素在疼痛中的作用 疼痛，并减轻疼痛的遗传性，以及 4) 疼痛的增长，包括双向关系 疼痛与发育过程中的一般失调之间的关系。慢性疼痛通常与情绪共存 我们检查疼痛和情绪、行为和生理失调的程度 具有共同的病因。为了实现我们的目标，我们建议进行纵向跟进（9、10 和 11 岁）的基于出生记录的社区样本包括 350 对不同种族的双胞胎儿童。 环境的早期风险和复原力方面已经得到了很好的描述，包括产科 根据医疗记录编码的并发症和新生儿发病率以及早期育儿。多方法 方法包括对双胞胎儿童的疼痛频率、强度、持续时间和残疾进行客观评估 以及他们的父母。将这些设计特征结合起来，可显着提高科学性 通过阐明支持预防性干预工作的流程来做出贡献。