Improved ultrasound imaging using elevated acoustic output

使用提高的声输出改进超声成像

基本信息

  • 批准号:
    9223699
  • 负责人:
  • 金额:
    $ 45.27万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-03-01 至 2019-12-31
  • 项目状态:
    已结题

项目摘要

 DESCRIPTION (provided by applicant): Ultrasonic imaging is among the most widely used abdominal imaging modalities in the United States. However, ultrasonic image quality is reported to be insufficient for diagnosis in up to 40% of patients, a challenge often correlated with obesity. The major problems are lack of penetration and reverberation clutter. We hypothesize that increasing the Mechanical Index (MI) from the current limit of 1.9 to values in the 2.4-3.4 range, with concomitant transmit pulse pressure increases from 40 to 200%, will markedly improve B-mode, har- monic, and Doppler image quality. We have designed this proposal to focus on harmonic imaging. Tissue harmonic imaging (THI) is a nonlinear method that is more robust to reverberation clutter and off-axis scattering than fundamental imaging, and has found great success in improving ultrasonic image quality. However, har- monic signal levels are 15-20 dB lower than fundamental signals, which leads to challenges with signal-to-noise ratio and depth penetration in difficult-to-image patients. The in situ pressures used in diagnostic ultrasound imaging have been subject to a de facto upper limit established by the United States FDA guidelines for the Mechanical Index (MI<1.9), a value which is based upon historic values, rather than being linked to scientific evidence of bioeffects. In tissues without gas bodies, cavitation based bioeffects have only been reported at diagnostic frequencies and pulse durations using MI values greater than 5.0. The American Institute of Ul- trasound in Medicine (AIUM) recently concluded that exceeding the recommended maximum MI given in the FDA guidance up to an estimated in situ value of 4.0, could be warranted without concern for increased risk of cavitation in non-fetal tissues without gas bodies, if imaging in this heretofore unexplored output regime were associated with a corresponding significant clinical benefit. We have obtained preliminary in vivo data using elevated MI harmonic imaging demonstrating +20 dB increases in harmonic signal level, penetration depth increases of up to 40%, and structural contrast-to-noise ratio increases from 12-500%, enabling visualization of additional structures. The primary goals of this work are to optimize elevated MI harmonic image quality and to quantify the resulting image quality improvements. There are 3 specific aims: 1) To extend our 3D nonlinear simulation tools to perform a parametric analysis of varying tissue properties and transducer configurations to optimize harmonic signal generation and image quality in elevated MI pulse inversion har- monic imaging, and to determine the relationship between water-based estimates and in situ measurements in the elevated MI output regime. 2) To design and implement a real-time prototype elevated MI system using commercial curvilinear abdominal arrays and a custom designed prototype large aperture low frequency diag- nostic array on a commercial grade scanner. 3) To quantify improvements in imaging performance afforded by the use of elevated MIs in patients scheduled for ultrasonic abdominal imaging studies, and in patients known to have malignant liver masses.
 描述(由申请人提供):超声成像是美国使用最广泛的腹部成像方式之一。然而,据报道,高达40%的患者的超声图像质量不足以诊断,这一挑战通常与肥胖有关。主要的问题是缺乏穿透力和混响杂波。我们假设,将机械指数(MI)从当前限值1.9增加到2.4-3.4范围内的值,同时将发射脉压从40%增加到200%,将显著改善B模式、谐波和多普勒图像质量。我们设计了这个提案,重点是谐波成像。组织谐波成像(THI)是一种非线性方法,比基波成像对混响杂波和离轴散射更鲁棒,并且在改善超声图像质量方面取得了巨大成功。然而,谐波信号电平比基波信号低15-20 dB,这导致难以成像的患者面临信噪比和深度穿透的挑战。超声诊断成像中使用的原位压力已受到美国FDA机械指数指南(MI<1.9)确定的实际上限的限制,该值基于历史值,而不是与生物效应的科学证据相关联。在组织中, 仅在诊断频率和脉冲持续时间下使用大于5.0的MI值报告了基于气穴的生物效应。美国超声医学研究所(AIUM)最近得出结论,如果在这种迄今为止尚未探索的输出方案中成像与相应的显著临床贝内相关,则超过FDA指南中给出的推荐最大MI高达原位估计值4.0是有道理的,而无需担心无气体体的非胎儿组织中的空化风险增加。我们已经获得了初步的体内数据,使用提高MI谐波成像显示+20 dB的谐波信号水平增加,穿透深度增加高达40%,结构对比噪声比从12- 500%增加,使其他结构的可视化。这项工作的主要目标是优化提高MI谐波图像质量,并量化由此产生的图像质量改善。有三个具体目标:1)扩展我们的3D非线性模拟工具,对不同的组织特性和换能器配置进行参数分析,以优化高MI脉冲反转谐波成像中的谐波信号生成和图像质量,并确定高MI输出状态下水基估计值与原位测量值之间的关系。2)设计和实现一个实时原型高架MI系统,使用商业曲线腹部阵列和商业级扫描仪上定制设计的原型大孔径低频诊断阵列。3)在计划进行腹部超声成像研究的患者和已知患有恶性肝脏肿块的患者中,量化使用升高的MI对成像性能的改善。

项目成果

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Kathryn Radabaugh Nightingale其他文献

Kathryn Radabaugh Nightingale的其他文献

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{{ truncateString('Kathryn Radabaugh Nightingale', 18)}}的其他基金

3D Shearwave Elasticity Biomarker Development for Neuromuscular Disease
神经肌肉疾病的 3D 剪切波弹性生物标志物开发
  • 批准号:
    10601107
  • 财政年份:
    2022
  • 资助金额:
    $ 45.27万
  • 项目类别:
Improved ultrasound imaging using elevated acoustic output
使用提高的声输出改进超声成像
  • 批准号:
    9083203
  • 财政年份:
    2016
  • 资助金额:
    $ 45.27万
  • 项目类别:
IMAGING OF FORMALIN-FIXED HUMAN PROSTATES AND REGISTRATION WITH HISTOLOGY
福尔马林固定的人类前列腺成像和组织学登记
  • 批准号:
    8363204
  • 财政年份:
    2011
  • 资助金额:
    $ 45.27万
  • 项目类别:
Radiation Force Imaging of Prostate Cancer and Guidance of Biopsy Procedures
前列腺癌的辐射力成像和活检程序指导
  • 批准号:
    8013858
  • 财政年份:
    2010
  • 资助金额:
    $ 45.27万
  • 项目类别:
Radiation Force Imaging of Prostate Cancer and Guidance of Biopsy Procedures
前列腺癌的辐射力成像和活检程序指导
  • 批准号:
    8403817
  • 财政年份:
    2010
  • 资助金额:
    $ 45.27万
  • 项目类别:
Image guided targeted biopsy of clinically significant prostate cancer with acoustic radiation force
利用声辐射力对具有临床意义的前列腺癌进行图像引导靶向活检
  • 批准号:
    10208767
  • 财政年份:
    2010
  • 资助金额:
    $ 45.27万
  • 项目类别:
Image guided targeted biopsy of clinically significant prostate cancer with acoustic radiation force
利用声辐射力对具有临床意义的前列腺癌进行图像引导靶向活检
  • 批准号:
    9978722
  • 财政年份:
    2010
  • 资助金额:
    $ 45.27万
  • 项目类别:
Radiation Force Imaging of Prostate Cancer and Guidance of Biopsy Procedures
前列腺癌的辐射力成像和活检程序指导
  • 批准号:
    7768872
  • 财政年份:
    2010
  • 资助金额:
    $ 45.27万
  • 项目类别:
Radiation Force Imaging of Prostate Cancer and Guidance of Biopsy Procedures
前列腺癌的辐射力成像和活检程序指导
  • 批准号:
    8594231
  • 财政年份:
    2010
  • 资助金额:
    $ 45.27万
  • 项目类别:
Radiation Force Imaging of Prostate Cancer and Guidance of Biopsy Procedures
前列腺癌的辐射力成像和活检程序指导
  • 批准号:
    8204773
  • 财政年份:
    2010
  • 资助金额:
    $ 45.27万
  • 项目类别:

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