Image guided targeted biopsy of clinically significant prostate cancer with acoustic radiation force

利用声辐射力对具有临床意义的前列腺癌进行图像引导靶向活检

基本信息

  • 批准号:
    9978722
  • 负责人:
  • 金额:
    $ 46.75万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2010
  • 资助国家:
    美国
  • 起止时间:
    2010-01-18 至 2022-07-31
  • 项目状态:
    已结题

项目摘要

Abstract: Over 1,000,000 biopsies are performed annually in the United States to diagnose prostate cancer (PCa)[1]. Prostate biopsies are performed using transrectal ultrasound (TRUS) guidance to diagnose PCa when suspicion is raised through screening mechanisms. However, ultrasonic prostate imaging does not facilitate targeting biopsies to suspicious regions because PCa does not have unique B-mode image characteristics that can delineate diseased tissues from normal structures and benign pathologies. Therefore, the current standard of care has poor sensitivity mainly because the sampling grid, which samples <5% of the prostate, only randomly intersects pathologic tissues. As a result, PCa detection rates are only 18-36% for both first and second-time repeat biopsies[1–5]. In addition, many of the cancers that are detected with the systematic sampling approach are clinically insignificant [2, 6], leading to overly aggressive treatment that adversely affects patients and places an unnecessary burden on our healthcare system. During the previous funding cycle we developed a novel 3D Acoustic Radiation Force Impulse (ARFI) prostate ultrasound elasticity imaging system. Our experience with 3D ARFI prostate imaging in over 100 patients demonstrated the exciting result that 3D ARFI imaging is specific for clinically significant disease (CSD)[7], which means it can be used to screen the entire prostate gland and target biopsies toward regions suspicious for CSD. We have identified the key technical challenges that must be addressed to bring a low-cost, 3D-ARFI prostate cancer screening and targeted biopsy guidance system into the current clinical work-flow. In this competing renewal, submitted under PAR- 15-075 for academic-industrial collaborations, we propose to partner with Siemens ultrasound to resolve these challenges and build a clinic-ready system and assess its performance in the clinic as compared to systematic TRUS biopsy. The proposed system will remove the random nature of systematic sampling, facilitating initial diagnosis based upon the most aggressive disease present in the gland. We hypothesize that this system will reduce the required number of biopsy cores, the number of repeat biopsy procedures, and the number of unnecessary radical prostatectomies associated with PCa. There are 3 specific aims: 1) To translate our prototype system into a clinic-ready system through: development and integration of a custom designed, side-fire transrectal transducer and biopsy needle guides, implementation of our data processing and 3D data visualization tools on-board a state-of-the-art prototype ultrasound scanner, and integration of positioning feedback in the motorized rotation system. 2) To assess the performance of the 3D TRUS ARFI targeted biopsy guidance system in tissue mimicking phantoms. 3) To assess the performance of 3D ARFI in vivo in humans in targeting clinically significant prostate disease.
翻译后摘要:在美国每年进行超过100万活检诊断前列腺癌 (PCa)[1]。在以下情况下,使用经直肠超声(TRUS)引导进行前列腺活检以诊断PCa: 通过甄别机制提出怀疑。然而,超声前列腺成像并不便于将活检靶向可疑区域,因为PCa不具有唯一的B模式图像特征, 从正常结构和良性病变中描绘出患病组织。因此,目前的标准 CARE的灵敏度很差,主要是因为对<5%的前列腺进行采样的采样网格仅是随机的 与病理组织相交因此,首次和第二次PCa检测率仅为18-36% 重复活检[1-5]。此外,许多通过系统抽样方法检测到的癌症 在临床上无意义[2,6],导致过度积极的治疗,对患者和地方产生不利影响 给我们的医疗系统带来不必要的负担在上一个融资周期中,我们开发了一种新颖的3D 声辐射力脉冲(ARFI)前列腺超声弹性成像系统。我们的经验与 100多例患者的3D ARFI前列腺成像显示了令人兴奋的结果, 是特异性的临床重大疾病(CSD)[7],这意味着它可以用来筛选整个 前列腺和可疑CSD区域的目标活检。我们已经确定了艾德必须解决的关键技术挑战,以实现低成本的3D-ARFI前列腺癌筛查,并有针对性地 活检引导系统进入目前的临床工作中-在这个竞争性的更新,根据PAR提交- 15-075对于学术-工业合作,我们建议与西门子超声合作解决这些问题 挑战,建立一个临床准备系统,并评估其在临床上的表现,与系统相比, TRUS活检。拟议的系统将消除随机性质的系统采样,促进初步诊断的基础上最积极的疾病目前在腺体。我们假设 该系统将减少所需的活检芯的数量、重复活检程序的数量以及 与PCa相关的不必要的根治性前列腺切除术的数量。有三个具体目标:(1)翻译 我们的原型系统,成为一个临床准备系统,通过:开发和集成的定制设计, 侧射经直肠传感器和活检针导向器,我们的数据处理和3D数据的实施 最先进的原型超声扫描仪上的可视化工具,以及电动旋转系统中的定位反馈的集成。2)评估3D TRUS ARFI靶向活检的性能 组织模拟体模中的引导系统。3)评估人体内3D ARFI的性能 针对临床上重要的前列腺疾病。

项目成果

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Kathryn Radabaugh Nightingale其他文献

Kathryn Radabaugh Nightingale的其他文献

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{{ truncateString('Kathryn Radabaugh Nightingale', 18)}}的其他基金

3D Shearwave Elasticity Biomarker Development for Neuromuscular Disease
神经肌肉疾病的 3D 剪切波弹性生物标志物开发
  • 批准号:
    10601107
  • 财政年份:
    2022
  • 资助金额:
    $ 46.75万
  • 项目类别:
Improved ultrasound imaging using elevated acoustic output
使用提高的声输出改进超声成像
  • 批准号:
    9083203
  • 财政年份:
    2016
  • 资助金额:
    $ 46.75万
  • 项目类别:
Improved ultrasound imaging using elevated acoustic output
使用提高的声输出改进超声成像
  • 批准号:
    9223699
  • 财政年份:
    2016
  • 资助金额:
    $ 46.75万
  • 项目类别:
IMAGING OF FORMALIN-FIXED HUMAN PROSTATES AND REGISTRATION WITH HISTOLOGY
福尔马林固定的人类前列腺成像和组织学登记
  • 批准号:
    8363204
  • 财政年份:
    2011
  • 资助金额:
    $ 46.75万
  • 项目类别:
Radiation Force Imaging of Prostate Cancer and Guidance of Biopsy Procedures
前列腺癌的辐射力成像和活检程序指导
  • 批准号:
    8013858
  • 财政年份:
    2010
  • 资助金额:
    $ 46.75万
  • 项目类别:
Radiation Force Imaging of Prostate Cancer and Guidance of Biopsy Procedures
前列腺癌的辐射力成像和活检程序指导
  • 批准号:
    8403817
  • 财政年份:
    2010
  • 资助金额:
    $ 46.75万
  • 项目类别:
Image guided targeted biopsy of clinically significant prostate cancer with acoustic radiation force
利用声辐射力对具有临床意义的前列腺癌进行图像引导靶向活检
  • 批准号:
    10208767
  • 财政年份:
    2010
  • 资助金额:
    $ 46.75万
  • 项目类别:
Radiation Force Imaging of Prostate Cancer and Guidance of Biopsy Procedures
前列腺癌的辐射力成像和活检程序指导
  • 批准号:
    7768872
  • 财政年份:
    2010
  • 资助金额:
    $ 46.75万
  • 项目类别:
Radiation Force Imaging of Prostate Cancer and Guidance of Biopsy Procedures
前列腺癌的辐射力成像和活检程序指导
  • 批准号:
    8204773
  • 财政年份:
    2010
  • 资助金额:
    $ 46.75万
  • 项目类别:
Radiation Force Imaging of Prostate Cancer and Guidance of Biopsy Procedures
前列腺癌的辐射力成像和活检程序指导
  • 批准号:
    8594231
  • 财政年份:
    2010
  • 资助金额:
    $ 46.75万
  • 项目类别:

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