Pasinetti: Overall; Dietary Botanicals in the Preservation of Cognitive and Psychological Resilience (Pasinetti)

帕西内蒂：总体而言；

• 批准号: 9506126
• 负责人: RICHARD A DIXON
• 金额: $ 16.95万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9506126
• 关键词: Acute; Anabolism; Behavioral; Bioavailable; Biological Availability; Biological Preservation; Biometry; Botanical dietary supplements; Botanicals; Brain; CREB1 gene; Chronic; Chronic stress; Cognitive; Collaborations; Data; Development; Diet; Dietary Polyphenol; Dissection; Electrophysiology (science); Event; Foundations; Future; Generations; Gnotobiotic; Goals; Grapes; Health Benefit; Human; Impaired cognition; In Vitro; Individual; Inflammatory Response; Intervention; Investigation; Juice; Knowledge; Life; Long-Term Potentiation; Maintenance; Mental Health; Modeling; Molecular; Mus; National Center for Complementary and Alternative Medicine; Neuraxis; Phenols; Phenotype; Physiological; Probiotics; Psychopathology; Research; Research Design; Research Project Grants; Research Support; Resveratrol; Role; Safety; Services; Signal Transduction; Sleep Deprivation; Stress; Stressful Event; Synapses; Synaptic plasticity; Testing; Therapeutic; Time; Tissues; Training; attenuation; base; career development; clinical application; cognitive function; data management; gastrointestinal; grape seed; gut microbiome; improved; in vivo; memory consolidation; microbiome; microbiota; next generation; novel; polyphenol; postsynaptic; pre-clinical; preclinical study; programs; psychologic; public health relevance; quality assurance; resilience; response; social; stressor; virtual

 DESCRIPTION (provided by applicant): We recently identified, in preclinical studies, specific polyphenol-rich botanical dietary supplements [e.g., grape seed polyphenol extract (GSPE), Concord grape juice (CGJ), and resveratrol (RSV)] that are effective in promoting cognitive and psychological resilience under stress conditions. The overall goal of the proposed Botanical Dietary Supplement Research Center (BDSRC) is to identify the specific polyphenol components from these bioactive botanical supplements that underlie their bioactivities and to characterize specific cellular/molecular mechanisms contributing to the attenuation of physiological stress, such as that associated to stressful life events, that have detrimental impact on psychological health, cognitive functions, and ultimately wellbeing (Projects 1-2). In addition the proposed studies will, for the first time, clarify the role of the gastrointestinal (G) microbiome, particularly the human GI microbiome, in modulating the bioavailability of polyphenol components responsible for the cognitive and psychological health benefits of dietary polyphenol botanical supplements using humanized "gnotobiotic" mice (Project 3). Thus, the proposed studies, which (1) characterize botanicals, (2) assess, pre-clinically, their bioavailability and bioactivity in the periphery and in the brain, while defining molecular mechanisms of resilience, and (3) identify safety issues essential for future development into clinical application, are in full alignment with the goals of NCCAM and ODS, as indicated in the Research Objectives of the RFA. The proposed studies in this BDSRC will improve scientific knowledge and technical capabilities through the development of a rigorous scientific program, will provide training and career development opportunities, and, critically, will provide an intellectually rigorous examination of the role of dietary polyphenol botanical supplements in the maintenance and promotion of psychological and cognitive resilience.

 描述(由申请人提供)：我们最近在临床前研究中确定了特定的富含多酚的植物性膳食补充剂[例如葡萄籽多酚提取物(GSPE)、协和葡萄汁(CGJ)和白藜芦醇(RSV)]，它们在促进压力条件下的认知和心理弹性方面有效。拟议的植物膳食补充剂研究中心(BDSRC)的总体目标是从这些生物活性植物补充剂中确定构成其生物活性的特定多酚成分，并确定有助于减轻生理压力的特定细胞/分子机制，例如与应激性生活事件相关的对心理健康、认知功能和最终福祉产生有害影响的机制(项目1-2)。此外，拟议的研究将首次阐明胃肠道(G)微生物组，特别是人类胃肠道微生物组，在调节多酚成分的生物利用度方面的作用，这些多酚成分是利用人源化的“GnotoBiotic”小鼠来补充膳食多酚植物补充剂的认知和心理健康益处的(项目3)。因此，拟议的研究(1)确定植物性药物的特征，(2)在临床前评估它们在外周和脑中的生物利用度和生物活性，同时确定弹性的分子机制，以及(3)确定未来发展到临床应用所必需的安全问题，这些研究完全符合RFA的研究目标中指出的NCCAM和ods的目标。该BDSRC的拟议研究将通过制定严格的科学计划来提高科学知识和技术能力，将提供培训和职业发展机会，更重要的是，将对膳食多酚植物补充剂在维持和促进心理和认知韧性方面的作用提供智力上的严格检验。