T32 Translational Addiction Research Fellowship Program

T32 转化成瘾研究奖学金计划

• 批准号: 9393067
• 负责人: Anna Rose Childress
• 金额: --
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9393067
• 关键词: Fellowship Program; Research; addiction

DESCRIPTION (provided by applicant): Addictions and the associated public health problems of HIV transmission, crime and violence, exact a severe toll on our nation, costing billions annually in health care, lost productivity, and incarceration. As there have been rapid advances in neuroscience and genetics in the past two decades, we need to speed the 'forward' translation of this knowledge into more effective clinical treatments for the addictions. Conversely, for addiction treatments with some known efficacy, we can now apply new neuroscience and genetic tools in 'backward-translation' -- e.g., finding why a treatment works well for some individuals, yet not at all for others. To help meet the need for skilled translatioal researchers, this application proposes a continuation of our T32 Translational Addiction Research Fellowship for pre- and post-doctoral trainees at the University of Pennsylvania. The training program will make explicit a long-standing translational tradition at Penn, integrating clinical and basic research strengths to create trainees, whether clinical or preclinical, Ph.D.'s or M.D.s, who will be able to accelerate addiction science in the next decade. The emphasis on translation is reflected at each level of the program - through the Co-PIs (clinical and basic, Drs. Childress and Pierce), the internal and external advisory board members, the formal didactics, the "dual" mentoring (each trainee will have both a clinical and preclinical mentor), and in the focus of trainees' mentored research projects. The translational emphasis of the program is driven by the recognition that addictions are complex disorders, multi-determined by interaction of genetic vulnerabilities, exposure to drug, and a host of modulating (e.g., early trauma, stress, cultural norms) influences. Trainees will thus be offered state-of-the-art knowledge about these interacting determinants through a didactic series specific to the program, and through mentored projects that may range from molecular and genetic studies, to brain systems (neuroscience and neuroimaging), to clinical treatment trials, and drug policy. This wide range of choices is enabled by the long history of excellence in addiction research at the University, reflected in the several academic research Centers (Penn-VA Addiction Research Center~ Translational Research Laboratories/CNB~ Center for Aids Research~ Transdisciplinary Tobacco Use Research Center~ Treatment Research Institute) and laboratories (Lucki lab, Mackler lab) offering skilled, successful mentors to the Fellowship. Mentored research also takes place within several affiliated treatment settings (VA, Presby-Penn, NIDA CTN sites, community methadone clinics, and mobile HIV Prevention units), critical for translating new research findings into the 'real world'.

描述（由申请人提供）：成瘾以及艾滋病毒传播，犯罪和暴力的相关公共卫生问题，对我们国家造成了严重的损失，每年损失了数十亿美元的医疗保健，生产力和监禁。在过去的二十年中，神经科学和遗传学的进步迅速，我们需要加快将这种知识转化为成瘾的更有效临床治疗方法的“正向”翻译。 相反，对于具有某些已知功效的成瘾治疗，我们现在可以在“向后翻译”中应用新的神经科学和遗传工具，例如，找出为什么一种治疗方法对某些人来说很好，但对其他人来说根本不起作用。 为了满足熟练翻译研究人员的需求，本申请提出了我们在宾夕法尼亚大学的T32翻译成瘾研究奖学金的延续。 该培训计划将使宾夕法尼亚州的长期转化传统成为临床和基础研究的长期传统，以创造受训者，无论是临床还是临床前博士，博士学位或M.D.S，他们将能够在未来十年中加速成瘾科学。对翻译的强调反映在程序的每个级别上 - 通过Co -Pis（临床和基本，Childress和Pierce博士），内部和外部咨询委员会成员，正式的教学，“双重”指导（每个受训者都会有临床和重创的导师），以及受训者的导师研究项目的重点。 翻译 该计划的重点是认识到成瘾是复杂的疾病的驱动，这是由于遗传脆弱性的相互作用，药物暴露以及许多调节（例如，早期创伤，压力，文化规范）的影响而多确定的。因此，通过特定于程序的教学级数，以及通过可能从分子和遗传研究到大脑系统（神经科学和神经影像学）到临床治疗试验以及药物政策的指导项目，将获得有关这些相互作用决定因素的最先进知识，并通过有指导的项目。这项广泛的选择是由大学成瘾研究卓越的悠久历史所促进的，反映在几个学术研究中心（Penn-VA成瘾研究中心〜转化研究实验室/CNB〜艾滋病研究中心〜跨学科烟草研究中心〜跨学科的烟草使用研究中心〜治疗研究所和实验室（Lucki Labler，Mackler，Mackler，成功），熟练的介绍了熟练的促销者，涉及熟练的促销者促进式促进式促进式促进式促销者。 奖学金。指导的研究还发生在几个关联的治疗环境（VA，Persby-Penn，NIDA CTN站点，美沙酮诊所和移动艾滋病毒预防单位）中，对于将新的研究发现转化为“现实世界”至关重要。