T32 Translational Addiction Research Fellowship Program

T32 转化成瘾研究奖学金计划

• 批准号: 9393067
• 负责人: Anna Rose Childress
• 金额: --
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9393067
• 关键词: Fellowship Program; Research; addiction

DESCRIPTION (provided by applicant): Addictions and the associated public health problems of HIV transmission, crime and violence, exact a severe toll on our nation, costing billions annually in health care, lost productivity, and incarceration. As there have been rapid advances in neuroscience and genetics in the past two decades, we need to speed the 'forward' translation of this knowledge into more effective clinical treatments for the addictions. Conversely, for addiction treatments with some known efficacy, we can now apply new neuroscience and genetic tools in 'backward-translation' -- e.g., finding why a treatment works well for some individuals, yet not at all for others. To help meet the need for skilled translatioal researchers, this application proposes a continuation of our T32 Translational Addiction Research Fellowship for pre- and post-doctoral trainees at the University of Pennsylvania. The training program will make explicit a long-standing translational tradition at Penn, integrating clinical and basic research strengths to create trainees, whether clinical or preclinical, Ph.D.'s or M.D.s, who will be able to accelerate addiction science in the next decade. The emphasis on translation is reflected at each level of the program - through the Co-PIs (clinical and basic, Drs. Childress and Pierce), the internal and external advisory board members, the formal didactics, the "dual" mentoring (each trainee will have both a clinical and preclinical mentor), and in the focus of trainees' mentored research projects. The translational emphasis of the program is driven by the recognition that addictions are complex disorders, multi-determined by interaction of genetic vulnerabilities, exposure to drug, and a host of modulating (e.g., early trauma, stress, cultural norms) influences. Trainees will thus be offered state-of-the-art knowledge about these interacting determinants through a didactic series specific to the program, and through mentored projects that may range from molecular and genetic studies, to brain systems (neuroscience and neuroimaging), to clinical treatment trials, and drug policy. This wide range of choices is enabled by the long history of excellence in addiction research at the University, reflected in the several academic research Centers (Penn-VA Addiction Research Center~ Translational Research Laboratories/CNB~ Center for Aids Research~ Transdisciplinary Tobacco Use Research Center~ Treatment Research Institute) and laboratories (Lucki lab, Mackler lab) offering skilled, successful mentors to the Fellowship. Mentored research also takes place within several affiliated treatment settings (VA, Presby-Penn, NIDA CTN sites, community methadone clinics, and mobile HIV Prevention units), critical for translating new research findings into the 'real world'.

描述（由申请人提供）：成瘾以及与之相关的艾滋病毒传播、犯罪和暴力等公共卫生问题给我们的国家造成了严重的损失，每年在医疗保健、生产力损失和监禁方面造成数十亿美元的损失。在过去的二十年里，神经科学和遗传学取得了长足的进步，我们需要加快将这些知识转化为更有效的成瘾临床治疗方法。