2023 Excitatory Synapses and Brain Function Gordon Research Conference and Seminar

项目摘要 这项提议要求部分支持一个长期的、受关注的和受欢迎的戈登研究公司 2023年6月4日至9日在Les Diablerets会议上举行的兴奋性突触和脑功能会议(GRC) 在瑞士的中心。在GRC之前，将举行戈登研究研讨会(GRS)，旨在 2023年6月3日至4日，研究生和博士后研究员在同一地点。 兴奋性突触是能够实现快速信号传输和相互通信的功能单位。 神经元。通过这些连接，神经元建立功能电路，处理必要的信息 产生所有的大脑功能。突触是目标 突触功能异常与几种神经和精神障碍有因果关系，包括 在许多常用的处方药物中，以及 精神分裂症、自闭症、抑郁症、药物成瘾、帕金森氏症、阿尔茨海默病、创伤性脑 因此，了解兴奋性突触的结构和功能 不仅是推断大脑功能知识的基础，也是找到新的大脑治疗策略的基础 疾病。会议将汇聚不同学科的优秀初级和高级科学家。 包括神经元生物学家、解剖学家、分子和发育生物学家、生物化学家、细胞/分子 成像师、生物物理学家和神经生理学家的目标是 受伤、中风和癫痫。 激发对当前概念的讨论 并为未来的研究定义新的挑战。该计划包括两次主题演讲和八次会议 它广泛地解决了突触电路解剖、学习和记忆过程、经验等当前问题- 依赖可塑性，技术进步，疾病的突触基础，NMDA受体结构和 功能，突触的规范和发育，从突触到基因的信号传递和返回。此外，海报 会议将允许所有参与者就这些主题发表意见。 除了被邀请的演讲者外，我们还将从提交的摘要中挑选初级科学家进行简短的口头演讲 演示文稿。该计划的设计不仅是为了突出尖端方法，还为了刺激 在基础神经科学健全的生物学框架内的新概念、新方法和新技术，但 也是为了促进科学界代表性不足的群体。这次会议将汇聚专家科学家 在世界范围内，在一个有利于讨论和交流思想的环境中。在网上交流思想 这次会议一直是这一领域的推动力。我们预计2023年关于兴奋性突触和 大脑功能将塑造未来的科学方向，并为NINDS的使命提供关键支持 与NIDA、NIMH、NICHD和NIA等其他NIH研究所一样。

Project Summary This proposal requests partial support for a longstanding, well-attended, and well-received Gordon Research Conference (GRC) on Excitatory Synapses and Brain Function on June 4-9, 2023, at Les Diablerets Conference Center in Switzerland. The GRC will be preceded by a Gordon Research Seminar (GRS) targeted towards graduate students and postdoctoral fellows on June 3-4, 2023, at the same location. Excitatory synapses are functional units that enable rapid signal transmission and communication between neurons. Through these connections, neurons establish functional circuits that process information necessary to generate all brain functions. Synapses are the target aberrant synaptic function is causally linked to several neurological and psychiatric disorders, including of many commonly prescribed medications, and schizophrenia, autism, depression, drug addiction, Parkinson's disease, Alzheimer's disease, traumatic brain Understanding the structure and function of excitatory synapses is therefore fundamental not only to infer knowledge about brain function but also to find new therapeutic strategies for brain diseases. The conference will bring together outstanding junior and senior scientists across different disciplines including neuron biologists, anatomists, molecular and developmental biologists, biochemists, cell/molecular imagers, biophysicists and neurophysiologists with the goal of injury, stroke and epilepsy. stimulating discussions about current concepts and defining new challenges for future research. The program includes two keynote lectures and eight sessions that broadly address current issues in synaptic circuit dissection, learning and memory processes, experience- dependent plasticity, technological advances, synaptic basis of the diseases, NMDA receptor structure and function, synaptic specification and development, signaling from synapses to genes and back. In addition, poster sessions will permit all participants to contribute to these topics. Besides the invited speakers, we will select junior scientists from the submitted abstracts for short oral presentations. The program has been designed not only to highlight cutting edge approaches and to stimulate new concepts, methods and technologies within a sound biological framework of fundamental neuroscience, but also to promote underrepresented groups in science. The conference will bring together expert scientists worldwide in an environment that is conducive to discussion and exchange of ideas. The exchange of ideas at this conference has been a driving force for the field. We expect the 2023 GRC on Excitatory Synapses and Brain Function will shape future scientific directions and provide critical support for the mission of NINDS as well as other NIH institutes such as NIDA, NIMH, NICHD and NIA.