Study of biomarkers in ovarian cancer: modulation by activity & diet intervention

卵巢癌生物标志物的研究：活性调节

基本信息

批准号：
9198724
负责人：
KAREN M BASEN-ENGQUIST
金额：
$ 63.08万
依托单位：
UNIVERSITY OF ARIZONA
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-01-01 至 2019-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9198724
关键词：
Adopted Aftercare Attention Behavior Therapy Behavioral Biological Biological Markers Blood specimen Cancer Advocacy Cancer Survivor Cancer Survivorship Cessation of life Cholesterol Clinical Community Clinical Oncology Program Control Groups Controlled Study Data Diet Dietary Intervention Disease Disease Progression Enrollment Funding Goals Gynecologic Oncology Group Health High Density Lipoproteins Inflammation Inflammatory Inflammatory Response Insulin Insulin Resistance Interleukin-6 Intervention Knowledge Life Style Lipids Low-Density Lipoproteins Malignant Female Reproductive System Neoplasm Malignant Neoplasms Malignant neoplasm of ovary Mediating Mesothelium Metabolic Monitor Obesity Outcome Participant Patient-Focused Outcomes Patients Physical activity Play Postdoctoral Fellow Progression-Free Survivals Protocols documentation Randomized Recurrence Recurrent disease Regulation Research Research Infrastructure Resources Risk Risk Factors Role Sampling Scanning Schedule Survivors Testing Time Translating Visceral Vulnerable Populations Woman Work X-Ray Computed Tomography arm attentional control base cancer diagnosis cancer survival design energy balance evidence base follow-up group intervention high risk improved indexing intervention effect lifestyle intervention lipid metabolism mortality novel outcome forecast programs public health relevance tumor progression

项目摘要

DESCRIPTION (provided by applicant): Ovarian cancer accounts for over 18,000 deaths each year in the U.S. with disease progression rates estimated at 60-70% after 4 years. The efficacy of a physical activity + dietary intervention to increase progression-free survival (PFS) in this vulnerable population is currently being tested in a hypothesis-driven, randomized, attention-control study of 1070 women with prior invasive disease [(Gynecological Oncology Group (GOG) 0225 study (Lifestyle Intervention for oVarian cancer Enhanced Survival- (LIVES) Trial]. Here, we propose to take advantage of the trial infrastructure and capacity to collect repeat blood samples to evaluate the mechanistic underpinnings that might explain any changes in health indices by treatment arm over time. The overarching hypothesis is that change in metabolic and inflammatory status of participants, that is expected to demonstrate a reduction in inflammation and metabolic deregulation in the intervention group participants more so than the attention-control group, will be associated with increased PFS. A secondary focus of the proposed work will be the interaction with central adiposity. The Specific Aims include: To determine if the LIVES intervention alters biomarkers of metabolic deregulation in women previously treated for stage II-IV ovarian cancer; Aim 2: To determine if any effect of the intervention on biomarkers is mediated by change in central adiposity; and Aim 3: To determine if any effect of the intervention on biomarkers is modified by baseline central adiposity including exploration of central adiposity using Computerized Tomography (CT) scans. Our longer term goal is to determine whether change in central adiposity, insulin/lipid metabolism or inflammation is associated with progression free survival.

描述（由申请人提供）：卵巢癌在美国每年占18,000多人死亡，疾病进展率估计为4年后60-70％。在该脆弱人群中，体育活动 +饮食干预措施增加无进展生存率（PFS）的功效目前正在通过假设驱动的，随机的，随机的，注意力控制的研究对1070名先前具有侵入性疾病的女性进行研究[（GOG）研究（GOG）0225研究（GOG）0225的生存（我们提出的生存）（我们对卵巢癌的生存）进行测试（我们对卵巢疗法的生存；试验的基础架构和收集重复样本的能力来评估可能随着时间的推移来解释治疗方指数的任何变化，这是参与者的代谢和炎症状态的变化，预计将证明炎症和代谢群体与二次参与者的关注点有关。拟议的工作将是与中心肥胖的相互作用。具体目的包括：确定生活干预措施是否改变了先前治疗的II-IV期卵巢癌的女性中代谢失调的生物标志物；目标2：确定干预对生物标志物的任何影响是否是由中心肥胖的变化介导的；目标3：确定干预对生物标志物的任何影响是否通过基线中心肥胖来改变使用计算机断层扫描（CT）扫描探索中央肥胖。我们的长期目标是确定中央肥胖，胰岛素/脂质代谢或炎症的变化是否与无进展生存有关。