Center for Transformative Community-Driven Research to Prevent Obesity-related Cancer

项目概要/摘要 预防肥胖相关癌症的社区驱动变革研究中心（中心） 致力于降低癌症风险，并最终改善患有持续性癌症的社区的癌症结果 贫穷。我们计划通过社区参与来弥合研究与现实世界实践之间的差距 解决肥胖问题的方法——肥胖是第二大可预防的癌症原因。该中心将重点 Acres Homes 的活动是德克萨斯州休斯顿的一个历史悠久的黑人社区，该社区经历了持续的 贫穷。该中心将在 MD 安德森癌症中心当前的本地癌症背景下测试干预措施 预防倡议（Be Well Communities™），围绕两个科学主题：1）了解社会和 贫困的环境背景（例如粮食不安全、娱乐基础设施有限、健康促进工作很少 服务）和 2）促进饮食和身体活动等健康行为的改变作为主要原因 肥胖症。这两个研究项目涵盖了从初级预防到癌症控制的整个过程 生存率：项目 1 将测试多层次营养干预对 BMI 和代谢健康的影响 Acres Homes 小学生及其家长和项目 2 将适应并测试 对 Acres Homes 癌症幸存者的身体机能进行身体活动干预。两者都会使用健康 促进交织的方法将干预措施嵌入 Acres Homes 的环境背景中 保持健康社区。研究项目使用的跨学科方法将整合行为 科学、实施科学、地理空间分析和健康传播。该中心将包括五个 核心：行政、研究和方法、职业提升、发展和参与核心。 我们的概念框架基于持续贫困的背景和行为科学 改变。在行为改变层面，概念框架纳入了COM-B（能力、 机会、动机-行为）行为改变模型。与 Acres Homes 社区合作 领导们，该中心的具体目标是： (1) 测试干预措施以解决肥胖相关的危险因素 在 Be Well™ Acres Homes 的背景下，采用健康促进交织的方法来治疗癌症 社区协作、规划和规划的现有基础设施； (2) 合作 居民和社区组织营造一个支持研究和 实施能够减轻持续贫困影响的方案； (3) 职业生涯支持 由早期职业研究人员（包括实习生和早期教师）组成的跨学科团队，并建立他们的 开展研究以促进持续贫困社区癌症预防和控制的专业知识， 重点关注来自代表性不足群体的受训者和调查员的发展。

Project Summary/Abstract Center for Transformative Community-Driven Research to Prevent Obesity-related Cancer (the Center) seeks to reduce cancer risk, and ultimately improve cancer outcomes for communities experiencing persistent poverty. We plan to bridge the gap between research and real-world practice through community-engaged approaches to address obesity—the second leading preventable cause of cancer. The Center will focus its activity on Acres Homes, a historic Black Community in Houston, Texas that has experienced persistent poverty. The Center will test interventions in the context of MD Anderson’s current place-based cancer prevention initiative (Be Well Communities™), around two scientific themes: 1) understanding social and environmental context of poverty (e.g., food insecurity, limited recreational infrastructure, few health promotion services) and 2) promoting health behavior changes of diet and physical activity as major contributing causes of obesity. The two research projects span the cancer control continuum from primary prevention to survivorship: Project 1 will test the effect of a multi-level nutrition intervention on BMI and metabolic health in Acres Homes elementary school students and their parents, and Project 2 will adapt and test the effect of a physical activity intervention for Acres Homes cancer survivors on physical functioning. Both will use a health promotion interweaving approach to embed the interventions in the environmental context of Acres Homes and Be Well Communities. The transdisciplinary approach used by the research projects will integrate behavioral science, implementation science, geospatial analytics, and health communication. The Center will include five cores: Administrative, Research and Methods, Career Enhancement, Developmental, and Engagement Core. Our conceptual framework is informed by both the context of persistent poverty and the science of behavior change. At the behavior change level, the conceptual framework incorporates the COM-B (Capability, Opportunity, Motivation -Behavior) model of behavior change. In collaboration with Acres Homes community leaders, the specific aims of the Center are to: (1) Test interventions to address risk factors for obesity-related cancers using a health promotion interweaving approach in the context of Be Well™ Acres Homes, building on the existing infrastructure of community collaboration, planning and programming; (2) Collaborate with residents and community organizations to foster an environment that supports the conduct of research and the implementation of programs that can alleviate the effects of persistent poverty; (3) Support the careers of transdisciplinary teams of early-career researchers including trainees and early stage faculty and build their expertise in conducting research to promote cancer prevention and control in persistent poverty communities, with a focus on development of trainees and investigators from under-represented groups.