Center for Transformative Community-Driven Research to Prevent Obesity-related Cancer

项目摘要/摘要 变革性社区主导的预防肥胖相关癌症研究中心 寻求降低癌症风险，并最终改善持续经历癌症的社区的癌症结果 贫穷。我们计划通过社区参与来弥合研究和现实世界实践之间的差距 解决肥胖的方法--第二大可预防的癌症原因。该中心将把重点放在 德克萨斯州休斯敦的一个历史悠久的黑人社区英亩之家的活动一直在经历 贫穷。该中心将在MD安德森目前基于地点的癌症的背景下测试干预措施 预防倡议(Be Well Community™)，围绕两个科学主题：1)了解社会和 贫穷的环境背景(例如，粮食不安全、娱乐基础设施有限、健康促进很少 服务)和2)促进饮食和体力活动的健康行为改变是主要原因 肥胖症。这两个研究项目跨越了从初级预防到癌症控制的整个过程 生存：项目1将测试多水平营养干预对体重指数和代谢健康的影响 Acres为小学生和他们的家长提供住房，项目2将适应和测试 英亩家园癌症幸存者体力活动干预对身体机能的影响。两者都将使用健康 促进交织的方法，将干预措施嵌入英亩住宅和 做好社区。研究项目使用的跨学科方法将整合行为学 科学、实施科学、地理空间分析和健康传播。该中心将包括五个 核心：管理、研究和方法、职业提升、发展和敬业度。 我们的概念框架同时受到持续贫困的背景和行为科学的启发 变化。在行为改变级别，概念框架结合了COM-B(能力， 机会、动机-行为)模式的行为改变。与英亩家园社区合作 领导们，该中心的具体目标是：(1)测试针对肥胖相关风险因素的干预措施 癌症在Be Well™亩房屋的背景下使用健康促进交织的方法，建立在 社区协作、规划和规划的现有基础设施；(2)与 居民和社区组织，以营造一个支持进行研究和 实施可减轻持续贫困影响的方案；(3)支持 由早期研究人员组成的跨学科团队，包括受训人员和早期教师，并建立他们的 在持续贫困社区开展促进癌症预防和控制的研究方面的专业知识， 重点是培养来自代表性不足群体的受训人员和调查人员。

Project Summary/Abstract Center for Transformative Community-Driven Research to Prevent Obesity-related Cancer (the Center) seeks to reduce cancer risk, and ultimately improve cancer outcomes for communities experiencing persistent poverty. We plan to bridge the gap between research and real-world practice through community-engaged approaches to address obesity—the second leading preventable cause of cancer. The Center will focus its activity on Acres Homes, a historic Black Community in Houston, Texas that has experienced persistent poverty. The Center will test interventions in the context of MD Anderson’s current place-based cancer prevention initiative (Be Well Communities™), around two scientific themes: 1) understanding social and environmental context of poverty (e.g., food insecurity, limited recreational infrastructure, few health promotion services) and 2) promoting health behavior changes of diet and physical activity as major contributing causes of obesity. The two research projects span the cancer control continuum from primary prevention to survivorship: Project 1 will test the effect of a multi-level nutrition intervention on BMI and metabolic health in Acres Homes elementary school students and their parents, and Project 2 will adapt and test the effect of a physical activity intervention for Acres Homes cancer survivors on physical functioning. Both will use a health promotion interweaving approach to embed the interventions in the environmental context of Acres Homes and Be Well Communities. The transdisciplinary approach used by the research projects will integrate behavioral science, implementation science, geospatial analytics, and health communication. The Center will include five cores: Administrative, Research and Methods, Career Enhancement, Developmental, and Engagement Core. Our conceptual framework is informed by both the context of persistent poverty and the science of behavior change. At the behavior change level, the conceptual framework incorporates the COM-B (Capability, Opportunity, Motivation -Behavior) model of behavior change. In collaboration with Acres Homes community leaders, the specific aims of the Center are to: (1) Test interventions to address risk factors for obesity-related cancers using a health promotion interweaving approach in the context of Be Well™ Acres Homes, building on the existing infrastructure of community collaboration, planning and programming; (2) Collaborate with residents and community organizations to foster an environment that supports the conduct of research and the implementation of programs that can alleviate the effects of persistent poverty; (3) Support the careers of transdisciplinary teams of early-career researchers including trainees and early stage faculty and build their expertise in conducting research to promote cancer prevention and control in persistent poverty communities, with a focus on development of trainees and investigators from under-represented groups.