Modeling mood course to detect markers for effective adaptive interventions

对情绪过程进行建模以检测有效适应性干预的标记

• 批准号: 9586320
• 负责人: Amy Louise Cochran
• 金额: $ 9.75万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-12-04 至 2021-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9586320
• 关键词: Modeling; mood; course; detect; markers

Project Summary Bipolar (BP) disorder is a chronic illness of profound shifts in mood ranging from mania to depression. BP is successfully treated by combining medication with psychosocial therapy, but care can prove inadequate in practice. With gaps in coverage and medication, along with imprecise guidelines on when, where, and how to intervene, promising psychosocial therapies require adaptive strategies to better address the specific needs of individuals in a timely manner (NIMH Strategy 2). To accomplish this, however, requires evidence-based practices for adapting a psychosocial therapy. This Mentored Research Scientist Development Award aims to address this knowledge gap, by (1) establishing a mobile health platform for translating a psychosocial therapy in BP into an effective adaptive intervention and (2) facilitating the transition of a junior researcher, at the interface of mathematics and psychiatry, into an independent researcher of effective adaptive interventions. The research effort is founded on a mobile health platform that combines evidence-based markers of mood for long-term monitoring with a micro-randomized trial, designed for optimizing mobile health adaptive interventions. In Aim 1, we use modeling to characterize and test new markers of mood course that account for volatility, a feature that masks effects of a therapy on mood. In Aim 2, we explore the potential for long-term monitoring of BP with interpretable markers from actigraphy. In Aim 3, best practices from Aim 1 and 2 are integrated with a micro-randomized trial into a mobile health platform. We then test the feasibility of using the platform to translate a psychosocial therapy, clinical phone call, into an adaptive intervention. If successful, this work will advance the Candidate's independent goal of adaptive scheduling of phone-calls with BP individuals. To complement the research agenda, the award will expand the Candidate's background in Computational Psychiatry into the area of Translational Psychiatry by providing training in five strategic areas: (1) clinical assessments, (2) psychosocial therapy, (3) mobile health interventions, (4) adaptive clinical trials, and (5) open-access scheduling. Dr. Melvin McInnis, Thomas B and Nancy Upjohn Woodworth Professor of Bipolar Disorder and Depression and Professor of Psychiatry at the University of Michigan, will be the primary mentor and will guide clinical aspects of the training (Training Objectives 1–3); Dr. Amy Kilbourne, Professor of Psychiatry and Acting Director of VA/HSR&D's Quality Enhancement Research Initiative, will guide training in the application of adaptive trial designs that involve psychosocial therapy (Training Objectives 2,4–5); and Dr. Susan Murphy, Herbert E. Robbins Distinguished Professor of Statistics, will guide training into methodology for adaptive trial design and mobile health interventions (Training Objectives 3–4). The proposed K01 award promises to train a junior scholar to address technically-challenging problems in mental health. This work is aligned with the NIH and NIMH missions of providing precise clinical care.

项目摘要 双相情感障碍（BP）是一种从躁狂到抑郁的情绪变化深刻的慢性疾病。BP是 通过药物治疗和心理治疗相结合，成功地治疗，但护理可能被证明是不够的， 实践随着覆盖范围和药物的差距，沿着关于何时，何地以及如何 干预，有前途的心理社会疗法需要适应性策略，以更好地解决特定的需求， 第二，及时采取行动（NIMH战略2）。然而，要做到这一点，需要基于证据的 适应心理社会疗法的实践。该指导研究科学家发展奖旨在 解决这一知识差距，方法是（1）建立一个移动的健康平台， 在BP的有效适应性干预和（2）促进过渡的初级研究人员，在 数学和精神病学的结合，成为有效适应性干预措施的独立研究人员。 这项研究工作建立在一个移动的健康平台上，该平台结合了基于证据的情绪标记， 通过微随机试验进行长期监测，旨在优化移动的健康适应性 干预措施。在目标1中，我们使用建模来表征和测试情绪过程的新标记， 波动性，这是一种掩盖治疗对情绪影响的特征。在目标2中，我们探索了长期的潜力， 用体动记录仪的可解释标记物监测BP。在目标3中，目标1和目标2的最佳做法是 与微随机试验整合到一个移动的健康平台中。然后，我们测试使用 将社会心理治疗、临床电话转化为适应性干预的平台。如果成功，这 工作将推进候选人的自适应调度与BP个人的电话呼叫的独立目标。 为了补充研究议程，该奖项将扩大候选人的计算背景， 通过在五个战略领域提供培训，将精神病学纳入转化精神病学领域：（1）临床 评估，（2）心理社会治疗，（3）移动的健康干预，（4）适应性临床试验，以及（5） 开放访问调度。Melvin McInnis博士、托马斯B和Nancy Upjohn Woodworth双相情感障碍教授 密歇根大学精神病学教授，将是主要的导师 并将指导培训的临床方面（培训目标1-3）; Amy基尔本博士， 精神病学和VA/HSR&D的质量提高研究计划的代理主任，将指导培训， 包括心理社会治疗的适应性试验设计的应用（培训目标2，4 -5）; 苏珊·墨菲，赫伯特E.罗宾斯杰出统计学教授将指导方法学培训 适应性试验设计和移动的健康干预（培训目标3-4）。 拟议的K 01奖承诺培养一名初级学者，以解决技术上具有挑战性的问题， 心理健康这项工作与NIH和NIMH提供精确临床护理的使命相一致。