Cerebral Diffusion: A new approach to sleep disorders

脑扩散：治疗睡眠障碍的新方法

• 批准号: 9372571
• 负责人: DAVID DUBOWITZ
• 金额: $ 23.25万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-04 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9372571
• 关键词: Acute; Address; Adult; Alzheimer' s Disease; Animal Model; Anisotropy; Astrocytes; Biological Markers; Brain; Cerebrospinal Fluid; Cerebrum; Characteristics; Cognitive; Complex; Degenerative Disorder; Diffuse; Diffusion; Diffusion Magnetic Resonance Imaging; Effectiveness; Electroencephalography; Entropy; Excision; Fluid Shifts; Gaussian model; Goals; Health; Homeostasis; Human; Impairment; Inflammation; Intercellular Fluid; Liquid substance; Magnetic Resonance Imaging; Maintenance; Measurement; Measures; Metabolism; Methodology; Methods; Modeling; Morphology; Mus; Neurites; Outcome Study; Pathway interactions; Physiological; Physiology; Polysomnography; Reproducibility; Rodent; Role; Route; Sedation procedure; Sleep; Sleep Apnea Syndromes; Sleep Disorders; Specificity; Subarachnoid Hemorrhage; Tauopathies; Techniques; Testing; Tissues; Traumatic Brain Injury; Waste Products; Work; Zaleplon; base; brain health; density; direct application; executive function; extracellular; improved; innovation; memory consolidation; neuroimaging; novel; novel strategies; preclinical study; relating to nervous system; three-dimensional modeling; wasting; water diffusion

Project Summary Recent studies in animal models have suggested a critical role for cerebrospinal fluid (CSF) / Interstitial fluid (ISF) flux through cerebral parenchyma for removal of byproducts of cellular metabolism and hence in maintaining the health of the brain. An important finding is that this interstitial fluid compartment shows dramatic increases during sleep, which points to a potentially important mechanism for sleep to maintain both acute homeostasis and long-term cerebral health. The central goal of these studies is to develop a sensitive measure of changes in cerebral ISF that may be a biomarker of sleep effectiveness. A key unanswered question still remains; How prevalent are these CSF/ISF pathways (and postulated pathophysiological sequelae) in the human brain? This exploratory work aims to establish the sensitivity and reproducibility of diffusion MRI changes as a non-invasive neuroimaging assessment of CSF/ISF shifts in humans during natural sleep and sedation. The outcome of these studies will be a new technique for characterization of normal sleep physiology, and for monitoring sleep disorders, based on sleep-dependent changes in CSF/ISF flux. It also offers a novel window into other cerebral insults that may disrupt the tissue microenvironment and thus may impair sleep effectiveness.

项目摘要 最近在动物模型中的研究表明，脑脊液在 通过脑实质的(CSF)/间质液体(ISF)通量用于去除副产物 对细胞新陈代谢的影响，从而维持大脑健康。一个重要的 研究发现，在睡眠期间，这种间质液体间隔显著增加， 这表明了睡眠的一种潜在的重要机制，它可以保持 动态平衡和长期的大脑健康。 这些研究的中心目标是开发一种灵敏的测量方法来衡量 大脑ISF可能是睡眠有效性的生物标志物。一个关键的未解答的问题 仍然存在；这些CSF/ISF途径有多普遍(和假设 病理生理后遗症)在人类大脑中？ 这项探索性工作旨在建立弥散磁共振成像的敏感性和重复性。 脑脊液/间歇性脑脊液移位的无创性神经影像评估 在自然睡眠和镇静期间。 这些研究的结果将是一种表征正常的新技术 睡眠生理学，以及基于睡眠依赖的睡眠障碍监测 脑脊液/胰岛素样生长因子流量的变化。它还为了解其他大脑侮辱提供了一个新的窗口 可能会破坏组织微环境，从而可能会损害睡眠效率。