Cerebral Diffusion: A new approach to sleep disorders

脑扩散：治疗睡眠障碍的新方法

• 批准号: 9372571
• 负责人: DAVID DUBOWITZ
• 金额: $ 23.25万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-04 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9372571
• 关键词: Acute; Address; Adult; Alzheimer' s Disease; Animal Model; Anisotropy; Astrocytes; Biological Markers; Brain; Cerebrospinal Fluid; Cerebrum; Characteristics; Cognitive; Complex; Degenerative Disorder; Diffuse; Diffusion; Diffusion Magnetic Resonance Imaging; Effectiveness; Electroencephalography; Entropy; Excision; Fluid Shifts; Gaussian model; Goals; Health; Homeostasis; Human; Impairment; Inflammation; Intercellular Fluid; Liquid substance; Magnetic Resonance Imaging; Maintenance; Measurement; Measures; Metabolism; Methodology; Methods; Modeling; Morphology; Mus; Neurites; Outcome Study; Pathway interactions; Physiological; Physiology; Polysomnography; Reproducibility; Rodent; Role; Route; Sedation procedure; Sleep; Sleep Apnea Syndromes; Sleep Disorders; Specificity; Subarachnoid Hemorrhage; Tauopathies; Techniques; Testing; Tissues; Traumatic Brain Injury; Waste Products; Work; Zaleplon; base; brain health; density; direct application; executive function; extracellular; improved; innovation; memory consolidation; neuroimaging; novel; novel strategies; preclinical study; relating to nervous system; three-dimensional modeling; wasting; water diffusion

Project Summary Recent studies in animal models have suggested a critical role for cerebrospinal fluid (CSF) / Interstitial fluid (ISF) flux through cerebral parenchyma for removal of byproducts of cellular metabolism and hence in maintaining the health of the brain. An important finding is that this interstitial fluid compartment shows dramatic increases during sleep, which points to a potentially important mechanism for sleep to maintain both acute homeostasis and long-term cerebral health. The central goal of these studies is to develop a sensitive measure of changes in cerebral ISF that may be a biomarker of sleep effectiveness. A key unanswered question still remains; How prevalent are these CSF/ISF pathways (and postulated pathophysiological sequelae) in the human brain? This exploratory work aims to establish the sensitivity and reproducibility of diffusion MRI changes as a non-invasive neuroimaging assessment of CSF/ISF shifts in humans during natural sleep and sedation. The outcome of these studies will be a new technique for characterization of normal sleep physiology, and for monitoring sleep disorders, based on sleep-dependent changes in CSF/ISF flux. It also offers a novel window into other cerebral insults that may disrupt the tissue microenvironment and thus may impair sleep effectiveness.

项目摘要 动物模型的最新研究表明，脑脊液的重要作用 （CSF） /间质液（ISF）通过大脑实质的通量去除副产物 细胞代谢，因此在维持大脑的健康方面。一个重要的 发现这种间隙液室在睡眠期间显示出急剧增加 哪个指向睡眠的潜在重要机制，以维持两种急性 稳态和长期大脑健康。 这些研究的核心目的是制定敏感的变化衡量 大脑ISF可能是睡眠有效性的生物标志物。一个关键的未解决问题 仍然存在；这些CSF/ISF途径多么普遍（并假定 人脑中的病理生理后遗症？ 这项探索性工作旨在建立扩散MRI的敏感性和可重复性 变化是人类中CSF/ISF转移的无创神经影像学评估 在自然的睡眠和镇静期间。 这些研究的结果将是一种表征正常的新技术 基于睡眠依赖性的睡眠生理学和监测睡眠障碍 CSF/ISF通量的变化。它还为其他大脑侮辱提供了一个新颖的窗口 可能会破坏组织微环境，从而损害睡眠效率。