Mentoring in Sleep Research and Sleep Interventions in Heart Disease, and Stroke

心脏病和中风的睡眠研究和睡眠干预的指导

• 批准号: 9288228
• 负责人: Henry Klar Yaggi
• 金额: $ 6.72万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-06 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9288228
• 关键词: Acute; Acute Disease; Advisory Committees; Award; Behavior; Biological Markers; Cardiovascular Diseases; Cardiovascular system; Case-Control Studies; Chronic Disease; Circadian Rhythms; Clinical Trials; Cohort Studies; Congestive Heart Failure; Continuous Positive Airway Pressure; Critical Care; Databases; Delirium; Development; Diabetes Mellitus; Disease; Drowsiness; Event; Excessive Daytime Sleepiness; Fatigue; Functional disorder; Funding; Future; Genetic Markers; Goals; Growth and Development function; Health; Health Care Costs; Healthcare; Heart Diseases; Human; Impaired cognition; Incidence; Injury; Institution; Intervention; Lung; Measures; Medicine; Mental Depression; Mentors; Mentorship; Methodology; Methods; Mid-Career Clinical Scientist Award (K24); Modeling; Myocardial; Myocardial Infarction; NCI Scholars Program; Observational Study; Outcome; Oxidative Stress; Patient Outcomes Assessments; Patients; Polysomnography; Prognostic Factor; Quality of life; Randomized Controlled Trials; Research; Research Methodology; Research Personnel; Research Project Grants; Retrospective Studies; Rewards; Risk Factors; Role; Severities; Sleep; Sleep Apnea Syndromes; Sleep Disorders; Sleep disturbances; Stroke; Supervision; Symptoms; Target Populations; Training; acute stroke; cardiovascular health; cardiovascular risk factor; career; career development; cohort; design; experience; falls; improved; inflammatory marker; interest; mortality; novel; patient oriented research; programs; public health relevance; symptom management; therapy design; translational study; virtual

 DESCRIPTION (provided by applicant): My research has focused on conducting both observational studies aimed at understanding the health outcomes, particularly the cardiovascular consequences, of sleep disorders and clinical trials examining the role of sleep interventions in improving health. The objectives of this mid-career mentoring award are to 1) support my continued growth and development as a mentor in patient oriented-research in the field of sleep medicine, 2) establish a sleep patient oriented research experience (SPORE) mentoring program in the section of Pulmonary, Critical Care, and Sleep Medicine at my institution, 3) and continue to advance my own research program in sleep-disordered breathing and cardiovascular disease. The proposed Sleep Patient Oriented Research Experience (SPORE) Program will focus on providing mentees with sleep research methods, patient-oriented research methods, and opportunities for formal training to support increasing methodological sophistication. A Senior Advisory Committee will be formed and will meet every 6 months to provide an assessment my mentorship program and advise on future career development. The specific aims of the research strategy are to: 1) carry out federally funded patient-oriented research and mentor young investigators exploring the interface between sleep disorders and adverse cardiovascular health outcomes, and 2) to develop new directions in the study of the interplay human sleep and health. Regarding the first aim, three independently derived and federally funded research projects, of which I am the PI, will provide the mentorship opportunities used to accomplish this aim. These projects consist of a long- term multicenter observational cohort study examining polysomnographic predictors of adverse cardiovascular outcomes, and two randomized controlled trials examining the impact of continuous positive airway pressure (CPAP) on several domains of markers of cardiovascular risk in two separate target populations: acute stroke and congestive heart failure. The second aim will consist of 3 separate funded CDA projects: one short-term single center translational study evaluating the relationship between sleep apnea severity and ST elevation myocardial infarction, one observational cohort study examining the relationship between circadian disruption and delirium in the ICU, and, finally, one case-control study to determine whether sleepiness is associated with elevated genetic markers of inflammation and oxidative stress among patients with sleep-disordered breathing. My commitment to mentorship is the primary reason I am applying for the K24 Award. I have found that mentoring trainees of various backgrounds and levels who share a passion to design high quality studies in order to improve the methods by which we deliver health care to be the most rewarding aspect of my profession. I am requesting that the K24 cover 25% of my effort to be fairly equally divided between direct mentoring activities, and the other goals listed above. 45% of my effort will be supported by additional research grants, thus 70% of my total effort will be spent on research-related activities.

 描述（由申请人提供）：我的研究重点是进行两项观察性研究，旨在了解睡眠障碍的健康结果，特别是心血管后果，以及研究睡眠干预在改善健康方面作用的临床试验。这个职业生涯中期指导奖的目标是：1）支持我作为睡眠医学领域以患者为导向的研究导师的持续成长和发展，2）在我所在机构的肺部，重症监护和睡眠医学部门建立以患者为导向的睡眠研究经验（SPORE）指导计划，3）继续推进我自己在睡眠呼吸障碍和心血管疾病方面的研究计划。拟议的睡眠患者为导向的研究经验（SPORE）计划将侧重于为学员提供睡眠研究方法，以患者为导向的研究方法，并提供正式培训的机会，以支持日益复杂的方法。将成立一个高级咨询委员会，每6个月召开一次会议，对我的导师计划进行评估，并就未来的职业发展提出建议。研究战略的具体目标是：1）开展联邦资助的以患者为导向的研究，指导年轻的研究人员探索睡眠障碍和不良心血管健康结果之间的界面，2）在人类睡眠和健康的相互作用研究中开发新的方向。关于第一个目标，三个独立衍生和联邦资助的研究项目，其中我是PI，将提供用于实现这一目标的导师机会。这些项目包括一项长期多中心观察性队列研究，检查不良心血管结局的多导睡眠图预测因子，以及两项随机对照试验，检查持续气道正压通气（CPAP）对两个独立目标人群（急性卒中和充血性心力衰竭）心血管风险标志物的几个领域的影响。第二个目标将包括三个单独的资助CDA项目：一项评估睡眠呼吸暂停严重程度与ST段抬高心肌梗死之间关系的短期单中心转化研究，一项检查ICU中昼夜节律紊乱与谵妄之间关系的观察性队列研究，以及，最后，一项病例对照研究，以确定睡眠呼吸障碍患者的嗜睡是否与炎症和氧化应激的遗传标记升高有关。我对导师的承诺是我申请K24奖的主要原因。我发现，指导不同背景和水平的学员，他们都热衷于设计高质量的研究，以改善我们提供医疗保健的方法，这是我职业中最有价值的方面。我要求K24占我工作的25%，以便在直接指导活动和上述其他目标之间公平分配。我的努力的45%将由额外的研究赠款支持，因此我的总努力的70%将用于研究相关的活动。