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SYNPLA: A scaleable method for monitoring circuit-specific learning-induced changes in synaptic strength

SYNPLA: A scaleable method for monitoring circuit-specific learning-induced changes in synaptic strength
SYNPLA：一种可扩展的方法，用于监测特定电路学习引起的突触强度变化
批准号：
9301350
负责人：
ROBERTO MALINOW
金额：
$92.47万
依托单位：
COLD SPRING HARBOR LABORATORY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
项目状态：
已结题
起止时间：
2015-09-25 至 2019-06-30
来源：
https://reporter.nih.gov/project-details/9301350
关键词：
AMPA ReceptorsAmygdaloid structureAnimalsAntibodiesAuditoryAutistic DisorderBehaviorBiochemicalBiological AssayBrainBrain regionCorpus striatum structureDNADetectionDiseaseElectron MicroscopyElectrophysiology (science)EnsureExcitatory SynapseGlutamate ReceptorGlutamatesGoalsHabenulaHippocampus (Brain)ImageIn SituIn VitroIndividualLaboratoriesLateralLearningLigationLong-Term PotentiationMediatingMemoryMental DepressionMethodsModernizationMolecularMonitorNeuraxisNeuronsNeurosciencesNucleotidesNucleus AccumbensOligonucleotidesPlayProteinsResolutionSignal TransductionSliceSpecificityStimulusSynapsesSynaptic plasticityTestingTimeValidationVentral Tegmental AreaWorkaddictionbasebehavioral plasticityexperiencein vivoneuropsychiatric disordernovelpostsynapticpresynapticpublic health relevancereceptortooltrafficking

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 DESCRIPTION (provided by applicant): The goal of this application is to develop SYNPLA, a specific, selective and high-throughput method for marking experience-induced plasticity with single synapse resolution. SYNPLA exploits our understanding of the molecular mechanism of long-term potentiation, which is mediated by the insertion of a specific subtype of glutamate receptor at recently potentiated synapses. In Aim 1 we develop SYNPLA in cultured neurons. In Aims 2 and 3 we apply it to two brain circuits, cortico-amygdalar and cortico-striatal respectively which are known to undergo experience dependent plasticity. SYNPLA has the potential to emerge as a powerful tool for dissecting the circuit mechanisms underlying behavioral plasticity.
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SYNPLA: A scaleable method for monitoring circuit-specific learning-induced changes in synaptic strength
  • 批准号：
    9037290
  • 项目类别：
  • 资助金额：
    $100.59万
  • 财政年份：
    2015
  • 负责人：
    ROBERTO MALINOW
  • 依托单位：
    COLD SPRING HARBOR LABORATORY
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