The Central Virginia Center on Drug Abuse Research

弗吉尼亚中部药物滥用研究中心

• 批准号: 9189703
• 负责人: William L. Dewey
• 金额: $ 59.74万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-12-01 至 2018-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9189703
• 关键词: Analytical Chemistry; Animals; Area; Behavior; Biomedical Research; Body Fluids; Breeding; Cardiovascular system; Chemicals; Chemistry; Collaborations; Core Grant; Country; Disease; Drug Addiction; Drug abuse; Endocannabinoids; Environment; Equipment; Faculty; Forensic Medicine; Funding; Funding Opportunities; Future; Gene Expression; Genetic; Genetic Engineering; Genotype; Goals; Grant; Human; Image; Institution; Ion Channel; Knowledge; Laboratories; Letters; Lipids; Methodology; Molecular Genetics; Mus; National Institute of Drug Abuse; Opioid; Paper; Pharmaceutical Preparations; Pharmacology and Toxicology; Pharmacy Schools; Pilot Projects; Productivity; Publishing; Recording of previous events; Recruitment Activity; Research; Research Personnel; Research Project Grants; Resources; Scientist; Signal Transduction; Societies; Substance Addiction; Substance abuse problem; Synthesis Chemistry; Technology; Time; Tissues; Toxicology; Training; Transgenic Organisms; Universities; Update; Viral Vector; Virginia; Work; craving; experience; gastrointestinal; innovation; interest; novel; planetary Atmosphere; prevent; programs; public health relevance; ranpirnase; receptor function; success; tool

DESCRIPTION (provided by applicant): The overall aim of this Center is to provide molecular, genetic, chemical and analytical knowledge and expertise to create new and enhance previously funded drug abuse research at this and neighboring universities. These Cores will provide up-to-date and innovative expertise that is somewhat oblique to the methodologies used in previously funded research. This will result in new collaborative research and enhance previously funded research in ways that could not have been contemplated just a few years ago. Cores in synthetic and analytical chemistry, genetics, genetically engineered altered mice/viral vectors, and receptor function will provide the opportunity for funded researchers to broaden the scope of their work to transform knowledge in very creative ways. The inclusion of chemistry, genetics and analytical Cores will fill a major void in our many research projects. The ability to continue to provide genetically altered mice with appropriate genotyping, etc., and the inclusion of expertise in viral vector technology are seen as major assets of this Center. Being able to have a collaborator elucidate receptor function changes for a substance found to alter behavior or craving for a drug provides the atmosphere for new and creative research. This type of collaboration among scientists at different institutions is rare and would take many months or years if in fact collaboration could be established at all. In this Center this type of collaboratin will be the norm. We are committed to provide considerable institutional support such as the use of an up-to-date imaging center and a forensic toxicology laboratory established by the university. We will match dollar for dollar the pilot project program and provide administrative support beyond the modest amount requested. The Cores will also be utilized by NlDA-funded investigators at the University of Virginia and George Mason University. Scholars at the relatively new Pharmacy School at Hampton University have expressed interest (letter from the dean) in the utilization of these Cores as they establish their research programs. We will also share all aspects of this Center with scientists throughout the country.

描述（由申请人提供）：本中心的总体目标是提供分子，遗传，化学和分析知识和专业知识，以创造新的和加强以前资助的药物滥用研究在这所大学和邻近大学。这些核心将提供最新和创新的专业知识，这些专业知识与以前资助的研究中使用的方法有些倾斜。这将导致新的合作研究，并以几年前无法想象的方式加强以前资助的研究。合成和分析化学、遗传学、基因工程改造小鼠/病毒载体和受体功能的核心将为获得资助的研究人员提供机会，拓宽他们的工作范围，以非常创造性的方式转化知识。包含化学，遗传学和分析核心将填补我们许多研究项目的主要空白。继续为转基因小鼠提供适当的基因分型等能力，以及在病毒载体技术方面的专业知识被视为该中心的主要资产。能够有一个合作者阐明一种物质的受体功能变化，这种物质被发现可以改变行为或对药物的渴望，这为新的创造性研究提供了氛围。不同机构的科学家之间的这种合作是罕见的，如果真的能够建立合作，也需要几个月或几年的时间。在本中心，这种合作将成为常态。我们承诺提供相当大的机构支持，例如使用大学建立的最新成像中心和法医毒理学实验室。我们将为试点项目提供等值的资金，并提供超出所要求的适度数额的行政支持。nda资助的弗吉尼亚大学和乔治梅森大学的研究人员也将使用这些芯片。汉普顿大学相对较新的药学院的学者们表示有兴趣在建立他们的研究项目时使用这些核心（院长的信）。我们还将与全国各地的科学家分享这个中心的各个方面。