The Central Virginia Center on Drug Abuse Research

弗吉尼亚中部药物滥用研究中心

• 批准号: 10604263
• 负责人: William L. Dewey
• 金额: $ 138.02万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-12-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10604263
• 关键词: Animals; Area; Atmosphere; Basic Science; Behavior; Bibliography; Biomedical Research; Body Fluids; Brain; Breeding; Cardiovascular system; Chemicals; Clinical Research; Collaborations; Core Facility; Core Grant; Country; Creativeness; Disease; Drug Addiction; Drug abuse; Endocannabinoids; Environment; Equipment; Faculty; Financial Hardship; Forensic Medicine; Fostering; Funding; Funding Opportunities; Gastrointestinal tract structure; Gene Expression; Genotype; Goals; Grant; Human; Infrastructure; Institution; Ion Channel; Journals; Knowledge; Laboratories; Leadership; Letters; Lipids; Measurement; Measures; Methodology; Modernization; Mus; Mutant Strains Mice; National Heart, Lung, and Blood Institute; National Institute of Drug Abuse; National Institute of General Medical Sciences; National Institute of Neurological Disorders and Stroke; Neuropharmacology; Opioid; Paper; Performance; Pharmaceutical Preparations; Pharmacology and Toxicology; Pharmacy Schools; Pharmacy facility; Pilot Projects; Productivity; Publications; Publishing; Recording of previous events; Records; Research; Research Personnel; Resources; Running; Sampling; Scientist; Signal Transduction; Societies; Substance Addiction; Substance abuse problem; Technology; Tissues; Toxicology; Training; Transgenic Organisms; United States; United States National Institutes of Health; Universities; Update; Viral Vector; Virginia; Work; base; biological systems; craving; drug of abuse; experience; gastrointestinal; gastrointestinal function; gastrointestinal system; imaging facilities; improved; innovation; instrument; interest; liquid chromatography mass spectrometry; medical schools; neurobehavioral; novel; opioid epidemic; prevent; programs; receptor; recruit; success; tool

Project Summary – Overall One of the overall goals of this center is to provide an environment in which investigators can conduct new, significant and innovative basic and clinical research utilizing bioanalytical technology, genetically altered mice, neurobehavioral measures and gastrointestinal studies to advance our knowledge of the effects of abused drugs on biological systems. Coordination through the Administrative Core will provide the necessary scientific, financial, and administrative infrastructure to support such an environment. Further, this center will provide these areas of expertise to enhance the research of the 21 projects in VCU's Department of Pharmacology and Toxicology currently funded by NIDA and 13 funded through other NIH institutes (NIAAA: 2; NINDS: 2; NIGMS: 1; NCI: 1; NIDDKD: 4; NHLBI: 2) or other federal agencies (NSF: 1). These cores will provide current and innovative expertise that is improved over the methodologies used in previously funded research. This will enhance previously funded research and foster new collaborative research in ways that could not have been contemplated just a few years ago. A Bioanalytical Core, Mutant Mouse/Viral Vector Core, Neuropharmacology Core, and a Gastrointestinal Function Core will provide the opportunity for funded researchers to broaden the scope of their work to transform knowledge in various creative ways. The ability to continue to provide genetically altered mice with appropriate genotyping, etc., and expertise in viral vector technology are major assets of this Center. Being able to have a collaborator elucidate receptor functional changes as part of the neuropharmacology core, identify a substance found to alter behavior or craving in the bioanalytical core, or identify deleterious effects in the gastrointestinal tract provides the atmosphere for new and creative mechanistic research. This type of collaboration among scientists at different institutions is rare and requires many months or perhaps years to establish, if at all. In this center this type of collaboration will be the norm. We are committed to providing considerable institutional support, such as the use of a modern imaging center and a forensic toxicology laboratory established by the university. We have commitments from the Dean of the School of Medicine, the Dean of the School of Pharmacy, and the Vice President for Research and Innovation to provide matching funds for our Pilot Projects program. The cores will also be available for use by NIDA-funded investigators at the University of Virginia and Eastern Virginia Medical School. Scholars at the relatively new Pharmacy School at Hampton University have begun collaborations with our researchers, as they continue to develop and expand their research programs. We will also continue to share all aspects of this center with scientists throughout the country. We have included numerous letters of support from collaborating investigators at other institutions within Virginia and across the country, showcasing the strength of our Center and its importance to drug abuse research being conducted throughout the United States.

项目概要-总体 该中心的总体目标之一是提供一个环境， 利用生物分析技术进行的重要和创新的基础和临床研究，转基因小鼠， 神经行为测量和胃肠道研究，以提高我们对滥用药物影响的认识 生物系统。通过行政核心进行协调， 金融和行政基础设施，以支持这样的环境。此外，该中心将提供这些 专业领域，以加强VCU药理学系的21个项目的研究， 毒理学目前由NIDA资助，13个由其他NIH研究所资助（NIAAA：2; NINDS：2; NIGMS： 1; NCI：1; NIDDKD：4; NHLBI：2）或其他联邦机构（NSF：1）。这些核心将提供电流和 创新的专业知识，是在以前资助的研究中使用的方法进行了改进。这将 加强以前资助的研究，并以不可能的方式促进新的合作研究。 就在几年前。生物分析核心，突变小鼠/病毒载体核心， 神经药理学核心和胃肠功能核心将提供资助的机会 研究人员扩大他们的工作范围，以各种创造性的方式转化知识。的能力 继续为基因改变的小鼠提供适当的基因分型等，以及病毒载体方面的专业知识 技术是本中心的主要资产。能够有一个合作者阐明受体功能 改变作为神经药理学核心的一部分，确定一种物质，发现改变行为或渴望， 生物分析核心，或确定胃肠道中的有害影响，为新的 和创造性的机械研究。不同机构的科学家之间的这种合作是罕见的 并且需要数月或数年来建立（如果有的话）。在这个中心，这种合作将是 标准。我们致力于提供大量的机构支持，例如使用现代成像技术， 该中心和法医毒理学实验室由大学建立。我们得到了院长的承诺 医学院院长、药学院院长和负责研究和 创新，为我们的试点项目计划提供配套资金。核心也将提供给 弗吉尼亚大学和东弗吉尼亚医学院由NIDA资助的研究人员使用。学者 汉普顿大学相对较新的药学院已经开始与我们的研究人员合作，因为他们 继续发展和扩大他们的研究项目。我们也将继续分享这方面的各个方面 全国各地的科学家。我们已经包括了许多支持信，从合作 弗吉尼亚州和全国其他机构的调查人员，展示了我们中心的实力 以及它对美国各地正在进行的药物滥用研究的重要性。

项目成果

Examination of the behavioral effects of ketamine in Sprague-Dawley and Wistar Kyoto rats.

检查氯胺酮对 Sprague-Dawley 和 Wistar京都大鼠的行为影响。

• 发表时间: 2022
• 期刊: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
• 作者: Zhang,Fan;Baasansukh,Tegshjargal;Shelton,KeithL;Porter,JosephH;Nicholson,KatherineL
• 通讯作者: Nicholson,KatherineL

High-performance liquid chromatography with tandem mass spectrometry for the determination of nine hallucinogenic 25-NBOMe designer drugs in urine specimens.

采用高效液相色谱串联质谱法测定尿液样本中的 9 种致幻性 25-NBOMe 设计药物。

• DOI: 10.1093/jat/bku005
• 发表时间: 2014
• 期刊: Journal of analytical toxicology
• 影响因子: 2.5
• 作者: Poklis,JustinL;Clay,DeborahJ;Poklis,Alphonse
• 通讯作者: Poklis,Alphonse

Stability of Tetrahydrocannabinol and Cannabidiol in Prepared Quality Control Medible Brownies.

四氢大麻酚和大麻二酚在制备的质量控制食用布朗尼中的稳定性。

• DOI: 10.1093/jat/bkw114
• 发表时间: 2017
• 期刊: Journal of analytical toxicology
• 影响因子: 2.5
• 作者: Wolf,CarlE;Poklis,JustinL;Poklis,Alphonse
• 通讯作者: Poklis,Alphonse

Impact of smoked cannabis on tobacco cigarette smoking intensity and subjective effects: A placebo-controlled, double-blind, within-subjects human laboratory study.

• DOI: 10.1037/pha0000391
• 发表时间: 2021-08
• 期刊: Experimental and clinical psychopharmacology
• 影响因子: 2.3
• 作者: Peters EN;Herrmann ES;Smith C;Wilhelm JA;Koszowski B;Halquist M;Kosmider L;Poklis J;Roth S;Bart S;Pickworth WB
• 通讯作者: Pickworth WB

Identification of Drugs in Parenteral Pharmaceutical Preparations from a Quality Assurance and a Diversion Program by Direct Analysis in Real-Time AccuTOFTM-Mass Spectrometry (DART-MS).

通过实时 AccuTOFTM 质谱 (DART-MS) 直接分析，通过质量保证和转移程序鉴定肠外药物制剂中的药物。

• DOI: 10.1093/jat/bkw065
• 发表时间: 2016
• 期刊: Journal of analytical toxicology
• 影响因子: 2.5
• 作者: Poklis,JustinL;Mohs,AmandaJ;Wolf,CarlE;Poklis,Alphonse;Peace,MichelleR
• 通讯作者: Peace,MichelleR