Schizophrenia: A Neuropsychiatric Perspective

描述（由申请人提供）：精神分裂症：神经精神病学观点是一项培训补助金，旨在为基础和临床神经科学家提供技能和经验 有必要启动一个跨学科的研究生涯，可以有助于了解精神分裂症谱系障碍的神经生物学。这种竞争性的更新应用程序利用了致力于研究和培训的资源，设施和教师的深度， 在宾夕法尼亚大学的转化神经科学。该计划锻造临床神经科学家的交叉施肥，具有评估和治疗精神病谱系障碍的专业知识，以及基础神经科学家，具有探索与精神病相关的神经机制的新方法。培训将在四个单元提供，反映研究者和实验室的浓度和该领域的状态：（1）认知和情感神经科学~（2）神经遗传学~（3）细胞和分子神经科学~（4）临床和发育神经科学。虽然每个受训人员将主要在一个单位内工作，但有一名导师监督研究培训，各单位将有共同的课程和讲习班。教学经验将由教师协调，以确保生物统计学和方法论、研究道德行为和神经科学坚实基础方面的培训。为期5年的博士后项目将有5名具有医学博士学位的学员，医学博士/博士和博士每个学位，为期两年的培训。该计划利用参与实验室的丰富经验，这些实验室拥有联合中心赠款，RO 1，培训计划，研讨会，并在所有学术活动中进行富有成效的合作。该培训计划与精神分裂症研究中心的学术议程相吻合，在那里，教师们通过在研究团队中合作，以可以作为学员榜样的方式进行互动。我们希望，我们的努力将继续有助于推动高质量的临床和基础神经科学家的职业生涯，他们可以共同推动该领域的发展。通过积极参与研究，结合教学课程工作，学员学会进行研究，将临床与基础神经科学联系起来，以了解精神分裂症和其他精神病谱系障碍的神经生物学。 培训委员会包括培训单位的科学领导人，协助项目主任协调 招聘和招生，确保研究员与导师和研究实验室的适当匹配，并监控培训的质量和进度。学员的研究项目涵盖参与实验室的范围，重点是精神病的神经生物学。值得注意的是，拟议中的计划是宾夕法尼亚大学唯一一个强调临床和基础神经科学家在复杂行为和精神病研究中的培训。它贡献了“临界质量”，为学员和我们创造了一个刺激和令人兴奋的研究环境。

DESCRIPTION (provided by applicant): Schizophrenia: A Neuropsychiatric Perspective is a training grant aiming to provide basic and clinical neuroscientists with the skills and experiences necessary to launch an interdisciplinary research career that can contribute to understanding the neurobiology of schizophrenia spectrum disorders. This competing renewal application capitalizes on the depth of resources, facilities and faculty dedicated to research and training in translational neuroscience at the University of Pennsylvania. The program forges cross-fertilization of clinical neuroscientists, with expertise in assessment and treatment of psychosis spectrum disorders, and basic neuroscientists, with new methodologies to probe neural mechanisms pertinent to psychosis. Training will be provided in four Units, reflecting concentrations of investigators and laboratories and state of the field: (1) Cognition and Affective Neuroscience~ (2) Neurogenetics~ (3) Cellular and Molecular Neuroscience~ (4) Clinical and Developmental Neuroscience. While each trainee will work primarily within a Unit, with a mentor supervising the research training, there will be common courses and workshops across Units. The didactic experiences will be coordinated by faculty to assure training in biostatistics and methodology, ethical conduct of research and a solid grounding in neuroscience. The 5-year post-doctoral program will have five trainees with M.D., M.D./Ph.D. and Ph.D. degrees, each trained for a period of 2-years. The program capitalizes on extensive experience of the participating laboratories, which have joint Center grants, RO1s, training programs, seminars, and enjoy a productive collaboration in all academic activities. The training program dovetails with the academic agenda of the Schizophrenia Research Center, where faculty interact by working collaboratively in research teams in ways that can serve as role models for trainees. We hope that our efforts will continue to help advance the careers of high quality clinical and basic neuroscientists who can move the field ahead collaboratively. Through active participation in research, combined with didactic course work, trainees learn to conduct research bridging clinical with basic neurosciences relevant to understanding the neurobiology of schizophrenia and other psychosis spectrum disorders. The Training Committee, which includes the scientific leaders of the Training Units, assists the Program Director in coordinating recruitment and admissions, assuring appropriate matching of Fellows to mentors and research laboratories, and monitoring quality and progress of training. Research projects of trainees span the scope of the participating laboratories with a focus on neurobiology of psychosis. Notably, the proposed program is the only one at Penn emphasizing the training of clinical and basic neuroscientists in the study of complex behavior and psychosis. It contributes the "critical mass," creating a stimulating and exciting research environment for trainees and for us.