One Health; Epidemiology of natural and deliberate contaminants (infectious and toxicities) in animals and animal food

项目摘要 在美国，供宠物食用的食物通常对宠物和人类都是安全的。 拿着食物。对这些食品廉价生产的需求，以及我们生活在一个 更加全球化的社会已经改变了宠物食品成分的来源。因此，已经有了 几起人畜共患传染病传播和中毒事件。狗体内存在沙门氏菌 零食和宠物食品会使接触它们的人或在脱毛时与宠物接触的人生病。 这样的细菌。这些疫情是由于加工过程中的污染造成的，很可能是可以预防的，但 绝对不是恶意的。在其他一些情况下，例如在三聚氰胺中毒的情况下， 是故意的，试图通过欺诈性的掺假替代来获利。 乔治亚大学通过其“同一个健康”倡议，致力于促进、培训和 在动物、人类和环境健康的所有领域进行研究。兽医学院 医学和国家兽医诊断实验室对国家及其成员有义务不 不仅进行诊断，而且还监测趋势并报告不寻常的疾病表现或模式。我们的 实验室非常认真地对待这一责任，多年来，我们的教职员工已经发表了 有这样发现的文章。此外，我们是第一个诊断狗三聚氰胺中毒的实验室。 由于罐装宠物食品中存在受污染的成分。我们不仅能够描述疫情的爆发 在美国，也通过与我们的合作者网络合作，将其与韩国的疫情联系起来。此外， Pi在鸡肠道微生物群的研究中做了大量的工作，包括分布 抗菌素耐药性，以及野生动物和环境中沙门氏菌的流行病学。 我们的实验室在病理学、细菌学、寄生虫学、病毒学、血清学和 分子生物学，包括高通量平台测试。我们的教职员工都是高素质的 致力于动物和公共卫生。我们的承诺体现在我们参加了许多项目 州和国家两级。我们是国家动物卫生实验室的核心实验室之一 网络(NAHLN)，并参加所有NAHLN监视测试。此外，我们还参加了 与FDA达成的另一项合作协议，评估火鸡宠物食品中是否存在沙门氏菌 此外，还进行了一项流行病学研究，研究狗和猫粪便中沙门氏菌的流行率 (1U8FD004318-01)和携带沙门氏菌的潜在危险因素。此外，我们目前正在进行 去年我们首次竞争性地续签了1U18FD004623-01-基础设施赠款，为此，我们在这里 都在寻求更新。到目前为止，我们对这笔赠款的所有要求都做出了非常积极的反应。因此， 雅典兽医诊断实验室和PI在这一应用中具有独特的地位 协助FDA实现本次竞争性续签中描述的项目的重要目标。

Project Summary In the United States food destined for pet consumption is normally safe for both the pets and the people who handle the food. The need for the cheap production of these food commodities and the fact that we live in a more global society has changed the sources of the components of pet food. As a result, there have been several occurrences of zoonotic infectious disease transmission and toxicities. Salmonella present in dog treats and pet food has sickened people that handle them or were in contact with their pets while shedding such bacteria. These outbreaks were due to contamination during processing, probably preventable, but definitely not malicious. In some other instances, such as in the case of melamine toxicosis, the introduction was deliberate in an effort to profit through the fraudulent substitution of an adulterant. The University of Georgia, through its “One Health” initiative, is committed to promoting, training, and conducting research in all areas of animal, human and environmental health. The College of Veterinary Medicine and the State Veterinary Diagnostic Laboratory have a duty to the state and to its constituents to not only perform diagnosis but also to monitor trends and report unusual disease presentations or patterns. Our laboratory takes this responsibility very seriously, and over the years our faculty members have published articles with such findings. Furthermore, we were the first laboratory to diagnose melamine toxicosis in dogs due to contaminated components present in canned pet food. We were not only able to describe the outbreak in the US, but also by working with our network of collaborators, link it to an outbreak in Korea. Moreover, the PI has worked extensively in the study of the chicken gut micro-biome, including the distribution of antimicrobial resistance, and the epidemiology of Salmonella in wildlife and the environment. Our laboratory has expertise in the areas of pathology, bacteriology, parasitology, virology, serology, and molecular biology, including high throughput platform testing. Our faculty and staff are highly qualified and are devoted to animal and public health. Our commitment is evident in our participation in many programs at the state and national levels. We are one of the core laboratories of the National Animal Health laboratory Network (NAHLN) and participate in all NAHLN surveillance testing. In addition, we are have participated in another cooperative agreement with the FDA assessing the presence of Salmonella in turkey-based pet treats as well as engaging in an epidemiological study looking at the prevalence of Salmonella in dog and cat feces (1U8FD004318-01) and the potential risk factors for Salmonella carriage. Furthermore, we are currently on the last year of our first competitive renewal of the 1U18FD004623-01-infrastructure grant, for which here by we are seeking renewal. We have been very responsive to all the requirements of this grant to date. Therefore, Athens Veterinary Diagnostic Laboratory and the PI in this application are uniquely positioned to assist the FDA in meeting the important goals of the project described in this competitive renewal.