One Health; Epidemiology of natural and deliberate contaminants (infectious and toxicities) in animals and animal food

一个健康；

• 批准号: 9475396
• 负责人: SUSAN SANCHEZ
• 金额: $ 3.15万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9475396
• 关键词: Health; Epidemiology; natural; deliberate; contaminants

Project Summary In the United States food destined for pet consumption is normally safe for both the pets and the people who handle the food. The need for the cheap production of these food commodities and the fact that we live in a more global society has changed the sources of the components of pet food. As a result, there have been several occurrences of zoonotic infectious disease transmission and toxicities. Salmonella present in dog treats and pet food has sickened people that handle them or were in contact with their pets while shedding such bacteria. These outbreaks were due to contamination during processing, probably preventable, but definitely not malicious. In some other instances, such as in the case of melamine toxicosis, the introduction was deliberate in an effort to profit through the fraudulent substitution of an adulterant. The University of Georgia, through its “One Health” initiative, is committed to promoting, training, and conducting research in all areas of animal, human and environmental health. The College of Veterinary Medicine and the State Veterinary Diagnostic Laboratory have a duty to the state and to its constituents to not only perform diagnosis but also to monitor trends and report unusual disease presentations or patterns. Our laboratory takes this responsibility very seriously, and over the years our faculty members have published articles with such findings. Furthermore, we were the first laboratory to diagnose melamine toxicosis in dogs due to contaminated components present in canned pet food. We were not only able to describe the outbreak in the US, but also by working with our network of collaborators, link it to an outbreak in Korea. Moreover, the PI has worked extensively in the study of the chicken gut micro-biome, including the distribution of antimicrobial resistance, and the epidemiology of Salmonella in wildlife and the environment. Our laboratory has expertise in the areas of pathology, bacteriology, parasitology, virology, serology, and molecular biology, including high throughput platform testing. Our faculty and staff are highly qualified and are devoted to animal and public health. Our commitment is evident in our participation in many programs at the state and national levels. We are one of the core laboratories of the National Animal Health laboratory Network (NAHLN) and participate in all NAHLN surveillance testing. In addition, we are have participated in another cooperative agreement with the FDA assessing the presence of Salmonella in turkey-based pet treats as well as engaging in an epidemiological study looking at the prevalence of Salmonella in dog and cat feces (1U8FD004318-01) and the potential risk factors for Salmonella carriage. Furthermore, we are currently on the last year of our first competitive renewal of the 1U18FD004623-01-infrastructure grant, for which here by we are seeking renewal. We have been very responsive to all the requirements of this grant to date. Therefore, Athens Veterinary Diagnostic Laboratory and the PI in this application are uniquely positioned to assist the FDA in meeting the important goals of the project described in this competitive renewal.

项目摘要 在美国，供宠物食用的食物通常对宠物和食用的人都是安全的。 处理食物。对廉价生产这些粮食商品的需求以及我们生活在一个 越来越全球化的社会已经改变了宠物食品成分的来源。结果， 几起人畜共患传染病的传播和毒性。犬只出现沙门氏菌 治疗和宠物食品已经生病的人，处理他们或在接触他们的宠物，而脱落 这样的细菌。这些爆发是由于加工过程中的污染，可能是可以预防的，但 绝对不是恶意的在其他一些情况下，如三聚氰胺中毒， 是故意的，试图通过欺诈性的掺假替代品获利。 格鲁吉亚的大学，通过其“一个健康”倡议，致力于促进，培训， 在动物、人类和环境健康的所有领域开展研究。兽医学院 医学和国家兽医诊断实验室对国家及其组成部分有义务不 不仅进行诊断，而且监测趋势和报告不寻常的疾病表现或模式。我们 实验室非常认真地对待这一责任，多年来，我们的教师发表了 文章有这样的发现。此外，我们是第一个诊断三聚氰胺中毒的狗实验室 因为罐装宠物食品中含有受污染的成分我们不仅能够描述这次爆发 在美国，也通过我们的合作者网络，将其与韩国的疫情联系起来。而且 PI在鸡肠道微生物组的研究方面进行了广泛的工作，包括肠道微生物的分布 抗生素耐药性以及野生动物和环境中沙门氏菌的流行病学。 我们的实验室在病理学、细菌学、寄生虫学、病毒学、血清学和 分子生物学，包括高通量平台测试。我们的教师和工作人员都是高素质的， 致力于动物和公共卫生。我们的承诺是显而易见的，我们参与了许多方案，在 州和国家一级。我们是国家动物卫生实验室的核心实验室之一 网络（NAHLN），并参与所有NAHLN监督测试。此外，我们还参加了 与FDA的另一项合作协议，评估火鸡宠物食品中沙门氏菌的存在， 同时还参与了一项流行病学研究，观察狗和猫粪便中沙门氏菌的流行情况 （1U 8 FD 004318 -01）和沙门氏菌携带的潜在风险因素。此外，我们目前正在 去年，我们第一次竞争性更新1U 18FD 004623 -01-基础设施赠款，为此，我们在这里 正在寻求更新。迄今为止，我们对这笔赠款的所有要求都非常敏感。因此，我们认为， 雅典兽医诊断实验室和本申请中的PI具有独特的定位， 协助FDA实现本竞争性更新中所述项目的重要目标。