Training in Biostatistics for Heart, Lung and Blood Disease Research

心脏、肺和血液疾病研究生物统计学培训

• 批准号: 9270074
• 负责人: James Dennis Neaton
• 金额: $ 19.12万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9270074
• 关键词: Biometry; Heart Diseases; Hematological Disease; Lung diseases; Research; Training

 DESCRIPTION (provided by applicant): There is a critical shortage of biostatisticians to work on clinical and translational research teams. This proposal aims to train predoctoral students to become biostatistical scientists that will provide leadership to multidisciplinary teams in academic settings that conduct research aimed at preventing and treating heart, lung, and blood disease. The training program is innovative, rigorous, and multidisciplinary. It builds on an already strong program that provides foundational courses in statistical theory and biostatistical applications and several existing collaborations to create a Heart, Lung, and Blood Disease Clinical Trials Area of Emphasis in our PhD program. This area of emphasis will include courses in cardiac physiology, public health aspects of cardiovascular disease, advanced clinical trial design, and a journal club/seminar series that focuses on the design, analysis, and reporting of clinical trials of interventions for the prevention and treatment of heart, lung, and blood disease Each trainee with have a senior biostatistical mentor, a junior biostatistical mentor who can serve as a role model, and a senior clinical mentor with expertise in heart, lung or blood disease. We also plan to promote interactions among our trainees and young clinical researchers. Trainees will develop methods and work on applications using data from clinical trials aimed at preventing and treating heart, lung, and blood disease. They will attend statistica and medical conferences with their mentors and, in order to gain an appreciation for field work and data collection, spend 2 weeks at a clinical site participating in an ongoing clinical trial. Trainees will be supported for 3 of their 5 years in our PhD program. Support for other years will come from a heart, lung, or blood disease research project. Salary, tuition, and limited travel support is requested for 2 new predoctoral trainees in each year of the grant. Substantial institutional support for this training program has been provided by the School of Public Health and the Division of Biostatistics. This reflects the institutional commitment to multidisciplinary research in general, and the recognition of the many challenges that exist to reduce the burden of heart, lung, and blood disease in the U.S. and worldwide. There is a critical shortage of biostatisticians to provide leadership to multidisciplinary teams conducting research aimed at preventing and treating heart, lung, and blood disease. This training program addresses this shortage by establishing an area of emphasis on heart, lung, and blood disease clinical trials in an already strong PhD program that provides foundational courses in statistical theory and biostatistical applications. This innovative training program includes course work on the underlying biology and epidemiology of these diseases and mentoring from a committed faculty of biostatisticians and senior clinicians. (End of Abstract)

 描述（由申请人提供）：临床和转化研究团队中的生物统计学家严重短缺。该提案旨在培训博士前学生成为生物统计科学家，为学术环境中的多学科团队提供领导，开展旨在预防和治疗心脏、肺和血液疾病的研究。培训计划创新、严谨、​​跨学科。它建立在一个已经很强大的项目的基础上，该项目提供统计理论和生物统计应用方面的基础课程，以及一些现有的合作，以在我们的博士项目中创建一个重点的心脏、肺和血液疾病临床试验领域。该重点领域将包括心脏生理学、心血管疾病的公共卫生方面、高级临床试验设计以及期刊俱乐部/研讨会系列，重点关注预防和治疗心脏、肺和血液疾病的干预措施的临床试验的设计、分析和报告。每位学员都有一名高级生物统计导师、一名可以充当榜样的初级生物统计导师和一名高级临床导师。 具有心脏、肺或血液疾病专业知识的导师。我们还计划促进学员和年轻临床研究人员之间的互动。学员将使用旨在预防和治疗心脏、肺和血液疾病的临床试验数据来开发方法并进行应用。他们将与导师一起参加统计和医学会议，为了获得对现场工作和数据收集的欣赏，他们将在临床现场花两周时间参与正在进行的临床试验。学员将在我们的博士课程 5 年中的 3 年获得支持。其他年份的支持将来自心脏、肺或血液疾病研究项目。每年资助 2 名新的博士前培训生，要求提供工资、学费和有限的旅行支持。公共卫生学院和生物统计司为该培训计划提供了大量机构支持。这反映了机构对多学科研究的总体承诺，以及对减轻美国和全世界心脏、肺和血液疾病负担所面临的许多挑战的认识。生物统计学家严重短缺，无法领导多学科团队进行旨在预防和治疗心脏、肺和血液疾病的研究。该培训计划通过在一个已经很强大的博士课程中建立一个重点领域来解决这一短缺，该博士课程提供统计理论和生物统计应用的基础课程，重点关注心脏、肺和血液疾病的临床试验。这个创新的培训计划包括这些疾病的基础生物学和流行病学的课程，以及由生物统计学家和高级临床医生组成的敬业的教师的指导。 （摘要完）