Training in Biostatistics for Heart, Lung and Blood Disease Research

心脏、肺和血液疾病研究生物统计学培训

• 批准号: 9270074
• 负责人: James Dennis Neaton
• 金额: $ 19.12万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9270074
• 关键词: Biometry; Heart Diseases; Hematological Disease; Lung diseases; Research; Training

 DESCRIPTION (provided by applicant): There is a critical shortage of biostatisticians to work on clinical and translational research teams. This proposal aims to train predoctoral students to become biostatistical scientists that will provide leadership to multidisciplinary teams in academic settings that conduct research aimed at preventing and treating heart, lung, and blood disease. The training program is innovative, rigorous, and multidisciplinary. It builds on an already strong program that provides foundational courses in statistical theory and biostatistical applications and several existing collaborations to create a Heart, Lung, and Blood Disease Clinical Trials Area of Emphasis in our PhD program. This area of emphasis will include courses in cardiac physiology, public health aspects of cardiovascular disease, advanced clinical trial design, and a journal club/seminar series that focuses on the design, analysis, and reporting of clinical trials of interventions for the prevention and treatment of heart, lung, and blood disease Each trainee with have a senior biostatistical mentor, a junior biostatistical mentor who can serve as a role model, and a senior clinical mentor with expertise in heart, lung or blood disease. We also plan to promote interactions among our trainees and young clinical researchers. Trainees will develop methods and work on applications using data from clinical trials aimed at preventing and treating heart, lung, and blood disease. They will attend statistica and medical conferences with their mentors and, in order to gain an appreciation for field work and data collection, spend 2 weeks at a clinical site participating in an ongoing clinical trial. Trainees will be supported for 3 of their 5 years in our PhD program. Support for other years will come from a heart, lung, or blood disease research project. Salary, tuition, and limited travel support is requested for 2 new predoctoral trainees in each year of the grant. Substantial institutional support for this training program has been provided by the School of Public Health and the Division of Biostatistics. This reflects the institutional commitment to multidisciplinary research in general, and the recognition of the many challenges that exist to reduce the burden of heart, lung, and blood disease in the U.S. and worldwide. There is a critical shortage of biostatisticians to provide leadership to multidisciplinary teams conducting research aimed at preventing and treating heart, lung, and blood disease. This training program addresses this shortage by establishing an area of emphasis on heart, lung, and blood disease clinical trials in an already strong PhD program that provides foundational courses in statistical theory and biostatistical applications. This innovative training program includes course work on the underlying biology and epidemiology of these diseases and mentoring from a committed faculty of biostatisticians and senior clinicians. (End of Abstract)

 描述（由申请人提供）：在临床和转化研究团队中工作的生物统计学家严重短缺。该提案旨在培养博士前学生成为生物统计科学家，为学术环境中的多学科团队提供领导，这些团队进行旨在预防和治疗心脏，肺和血液疾病的研究。培训计划是创新的，严格的，多学科的。它建立在一个已经强大的计划，提供统计理论和生物统计应用的基础课程和几个现有的合作，以创建一个心脏，肺和血液疾病临床试验领域的重点在我们的博士课程。这一重点领域将包括心脏生理学课程，心血管疾病的公共卫生方面，先进的临床试验设计，以及期刊俱乐部/研讨会系列，重点是心脏，肺和血液疾病预防和治疗干预措施的临床试验的设计，分析和报告。一位可以作为榜样的初级生物统计学导师，以及一位具有心脏、肺或血液疾病专业知识的高级临床导师。我们还计划促进我们的学员和年轻临床研究人员之间的互动。学员将开发方法，并使用旨在预防和治疗心脏，肺和血液疾病的临床试验数据进行应用。他们将与导师一起参加临床和医学会议，为了获得对现场工作和数据收集的赞赏，他们将在临床研究中心参加正在进行的临床试验。学员将在我们的博士课程中获得5年中的3年支持。其他年份的支持将来自心脏，肺或血液疾病研究项目。工资，学费和有限的旅行支持要求在每年的补助金2新的博士前学员。公共卫生学院和生物统计司为这一培训方案提供了大量的机构支持。这反映了机构对多学科研究的承诺，以及对美国和世界范围内减少心脏，肺和血液疾病负担的许多挑战的认识。生物统计学家严重短缺，无法领导多学科团队开展旨在预防和治疗心脏、肺和血液疾病的研究。该培训计划通过在已经强大的博士课程中建立心脏，肺和血液疾病临床试验的重点领域来解决这一短缺问题，该博士课程提供统计理论和生物统计应用的基础课程。这个创新的培训计划包括这些疾病的基础生物学和流行病学课程，以及来自生物统计学家和高级临床医生的专业指导。(End摘要）