Training in Biostatistics for Heart, Lung and Blood Disease Research

 描述(由申请人提供)：临床和翻译研究团队严重缺乏生物统计学家。这项建议旨在培养博士生成为生物统计学科学家，为学术环境中的多学科团队提供领导，这些团队开展旨在预防和治疗心肺和血液疾病的研究。培训计划具有创新性、严谨性和多学科的特点。它建立在一个已经很强大的项目的基础上，该项目提供统计理论和生物统计学应用方面的基础课程，以及几个现有的合作项目，以创建我们博士项目中重点关注的心脏、肺和血液疾病临床试验领域。这一重点领域将包括心脏生理学、心血管疾病的公共卫生方面的课程、高级临床试验设计，以及侧重于预防和治疗心肺和血液疾病干预措施的临床试验的设计、分析和报告的期刊俱乐部/研讨会系列，每个学员都有一名高级生物统计导师、一名可以作为榜样的初级生物统计导师以及一名具有心肺或血液疾病专业知识的高级临床导师。我们还计划促进实习生和年轻临床研究人员之间的互动。受训者将利用旨在预防和治疗心脏、肺和血液疾病的临床试验数据开发方法和应用程序。他们将和他们的导师一起参加统计和医学会议，为了欣赏现场工作和数据收集，他们将在临床现场花两周时间参加正在进行的临床试验。学员将在我们的博士项目中的5年中获得3年的支持。对其他年份的支持将来自心脏、肺或血液疾病研究项目。在每一年的资助中，2名新的博士前实习生需要工资、学费和有限的旅行支持。公共卫生学院和生物统计司为这一培训方案提供了大量的机构支持。这反映了机构对多学科研究的总体承诺，以及对在美国和世界范围内减轻心肺和血液疾病负担存在的许多挑战的认识。目前严重缺乏生物统计学家来领导多学科团队开展旨在预防和治疗心脏、肺和血液疾病的研究。这一培训计划通过在已经很强大的博士课程中建立心脏、肺和血液疾病临床试验的重点领域来解决这一不足，该博士课程提供统计理论和生物统计应用的基础课程。这一创新的培训计划包括这些疾病的基本生物学和流行病学方面的课程工作，以及来自致力于生物统计学家和高级临床医生的教师的指导。(摘要结束)

 DESCRIPTION (provided by applicant): There is a critical shortage of biostatisticians to work on clinical and translational research teams. This proposal aims to train predoctoral students to become biostatistical scientists that will provide leadership to multidisciplinary teams in academic settings that conduct research aimed at preventing and treating heart, lung, and blood disease. The training program is innovative, rigorous, and multidisciplinary. It builds on an already strong program that provides foundational courses in statistical theory and biostatistical applications and several existing collaborations to create a Heart, Lung, and Blood Disease Clinical Trials Area of Emphasis in our PhD program. This area of emphasis will include courses in cardiac physiology, public health aspects of cardiovascular disease, advanced clinical trial design, and a journal club/seminar series that focuses on the design, analysis, and reporting of clinical trials of interventions for the prevention and treatment of heart, lung, and blood disease Each trainee with have a senior biostatistical mentor, a junior biostatistical mentor who can serve as a role model, and a senior clinical mentor with expertise in heart, lung or blood disease. We also plan to promote interactions among our trainees and young clinical researchers. Trainees will develop methods and work on applications using data from clinical trials aimed at preventing and treating heart, lung, and blood disease. They will attend statistica and medical conferences with their mentors and, in order to gain an appreciation for field work and data collection, spend 2 weeks at a clinical site participating in an ongoing clinical trial. Trainees will be supported for 3 of their 5 years in our PhD program. Support for other years will come from a heart, lung, or blood disease research project. Salary, tuition, and limited travel support is requested for 2 new predoctoral trainees in each year of the grant. Substantial institutional support for this training program has been provided by the School of Public Health and the Division of Biostatistics. This reflects the institutional commitment to multidisciplinary research in general, and the recognition of the many challenges that exist to reduce the burden of heart, lung, and blood disease in the U.S. and worldwide. There is a critical shortage of biostatisticians to provide leadership to multidisciplinary teams conducting research aimed at preventing and treating heart, lung, and blood disease. This training program addresses this shortage by establishing an area of emphasis on heart, lung, and blood disease clinical trials in an already strong PhD program that provides foundational courses in statistical theory and biostatistical applications. This innovative training program includes course work on the underlying biology and epidemiology of these diseases and mentoring from a committed faculty of biostatisticians and senior clinicians. (End of Abstract)