Mechanisms of IgA - mediated immunity to Vibrio cholerae
IgA 介导的霍乱弧菌免疫机制
基本信息
- 批准号:9438996
- 负责人:
- 金额:$ 4.68万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-04-20 至 2019-01-31
- 项目状态:已结题
- 来源:
- 关键词:AcuteAffectAgglutinationAnabolismAntibodiesAntibody ResponseAppearanceBacteriaBacterial PhysiologyBangladeshBindingBiological AssayBullaCell Membrane PermeabilityCellsChloridesCholeraCholera ToxinCholera VaccineCommunitiesComplexDevelopmentDiarrheaDimerizationDiseaseEnterocytesEpithelialEpitopesFab ImmunoglobulinsFlagellaGene ExpressionGene Expression RegulationGenetic TranscriptionGoalsGram-Negative BacteriaGuanosine MonophosphateHumanHuman ResourcesImmune systemImmunityImmunoglobulin AImmunoglobulin GIn VitroIndividualInfectionIntestinesLaboratoriesLeadLifeLipopolysaccharidesMeasuresMediatingMembraneMembrane PotentialsMicrobial BiofilmsMorphologyMucosal ImmunityMucous body substanceMusNeonatalPeriodicityPermeabilityPhysiologyPrincipal InvestigatorProductionReportingResearchResearch Project GrantsResistanceRuralSecond Messenger SystemsSecretory Immunoglobulin ASeriesSerotypingSignal Transduction PathwaySmall IntestinesStressSurfaceTechnologyTestingTimeUp-RegulationVaccinesVibrio choleraeVirulenceVirulence FactorsWorkbasebiological adaptation to stresscell motilitydimerenteric pathogenepidemiology studyexperienceextracellulargene repressioninhibitor/antagonistinnovationintestinal epitheliummouse modeloral vaccinepathogenpreventprogramsprotective effectpublic health relevanceresponsetranscriptome sequencingvirtual
项目摘要
DESCRIPTION (provided by applicant): The long-term goal of this research project is to develop more effective oral vaccines against Vibrio cholerae, the causative agent of cholera, a life threatening diarrheal disease that remains endemic in many parts of the developing world. While there is mounting evidence from epidemiological studies to suggest that IgA antibodies directed against bacterial lipopolysaccharide (LPS) are the primary determinants of immunity to V. cholerae, virtually nothing is known about how these antibodies affect the bacterium's capacity to colonize the intestinal epithelium. This proposal will test the hypothesis that the binding of LPS-specific IgA (and IgG) antibodies to the surface of V. cholerae has direct impact on bacterial physiology and virulence. Aim 1 will test the hypothesis that LPS-specific IgA (and IgG) antibodies induce changes in V. cholerae membrane potential, permeability and ultrastructure. Aim 2 will test the hypothesis that LPS-specific IgA (and IgG) antibodies also trigger changes in the bacterial virulence gene expression and signal transduction pathways. The principal investigator is a leading expert in the field of IgA-pathogen interactions, while key
personnel have expertise in V. cholerae physiology and virulence.
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Passive Immunity to Vibrio cholerae O1 Afforded by a Human Monoclonal IgA1 Antibody Expressed in Milk.
- DOI:10.20411/pai.v5i1.370
- 发表时间:2020
- 期刊:
- 影响因子:0
- 作者:Baranova DE;Chen L;Destrempes M;Meade H;Mantis NJ
- 通讯作者:Mantis NJ
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Nicholas J. Mantis其他文献
Collaboration of epithelial cells with organized mucosal lymphoid tissues
上皮细胞与有组织的黏膜淋巴样组织的协作
- DOI:
10.1038/ni1101-1004 - 发表时间:
2001-11-01 - 期刊:
- 影响因子:27.600
- 作者:
Marian R. Neutra;Nicholas J. Mantis;Jean-Pierre Kraehenbuhl - 通讯作者:
Jean-Pierre Kraehenbuhl
Inter-laboratory harmonization of microsphere immunoassays for SARS-CoV-2 antibody detection in contrived dried blood spots and oral fluids
用于在人为干血斑和口腔液中检测 SARS-CoV-2 抗体的微球免疫测定的实验室间协调
- DOI:
10.1128/spectrum.02690-24 - 发表时间:
2025-03-31 - 期刊:
- 影响因子:3.800
- 作者:
Kate L. DeRosa;Nora Pisanic;Kate Kruczynski;Christopher D. Heaney;Linda M. Styer;Nicholas J. Mantis - 通讯作者:
Nicholas J. Mantis
A type-specific B-cell epitope at the apex of outer surface protein C (OspC) of the Lyme disease spirochete, emBorreliella burgdorferi/em
莱姆病螺旋体伯氏疏螺旋体外表面蛋白 C(OspC)顶点的一种特定类型 B 细胞表位
- DOI:
10.1128/spectrum.02883-24 - 发表时间:
2025-02-14 - 期刊:
- 影响因子:3.800
- 作者:
David J. Vance;Grace Freeman-Gallant;Kathleen McCarthy;Carol Lyn Piazza;Yang Chen;Clint Vorauer;Beatrice Muriuki;Michael J. Rudolph;Lisa Cavacini;Miklos Guttman;Nicholas J. Mantis - 通讯作者:
Nicholas J. Mantis
Antibody signatures elicited by potent and subpotent whole-cell pertussis vaccines in mice
强效和次强效全细胞百日咳疫苗在小鼠中引发的抗体特征
- DOI:
10.1128/spectrum.03253-24 - 发表时间:
2025-03-31 - 期刊:
- 影响因子:3.800
- 作者:
Yetunde Adewunmi;Jennifer Doering;Prashant Kumar;Jozelyn V. Pablo;Andy A. Teng;Vu Huynh;Kathryn Secrist;David B. Volkin;Sangeeta B. Joshi;Joseph J. Campo;Nicholas J. Mantis - 通讯作者:
Nicholas J. Mantis
Nicholas J. Mantis的其他文献
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{{ truncateString('Nicholas J. Mantis', 18)}}的其他基金
Leveraging a transcription regulatory network to understand Salmonella invasion of host epithelial cells
利用转录调控网络了解沙门氏菌对宿主上皮细胞的侵袭
- 批准号:
10154895 - 财政年份:2021
- 资助金额:
$ 4.68万 - 项目类别:
Leveraging a transcription regulatory network to understand Salmonella invasion of host epithelial cells
利用转录调控网络了解沙门氏菌对宿主上皮细胞的侵袭
- 批准号:
10374120 - 财政年份:2021
- 资助金额:
$ 4.68万 - 项目类别:
Lyme Disease: B cell epitope discovery and mechanisms of antibody protection
莱姆病:B 细胞表位发现和抗体保护机制
- 批准号:
10677521 - 财政年份:2020
- 资助金额:
$ 4.68万 - 项目类别:
High-Throughput Dried Blood Spot (HT-DBS) Technologies in SARS COV-2 Serology and Vaccinology
SARS COV-2 血清学和疫苗学中的高通量干血斑 (HT-DBS) 技术
- 批准号:
10855042 - 财政年份:2020
- 资助金额:
$ 4.68万 - 项目类别:
Lyme Disease: B cell epitope discovery and mechanisms of antibody protection
莱姆病:B 细胞表位发现和抗体保护机制
- 批准号:
10246232 - 财政年份:2020
- 资助金额:
$ 4.68万 - 项目类别:
High-Throughput Dried Blood Spot (HT-DBS) Technologies in SARS COV-2 Serology and Vaccinology
SARS COV-2 血清学和疫苗学中的高通量干血斑 (HT-DBS) 技术
- 批准号:
10222023 - 财政年份:2020
- 资助金额:
$ 4.68万 - 项目类别:
Tickborne Disease: B cell epitope discovery and mechanisms of antibody Protection
蜱传疾病:B 细胞表位发现和抗体保护机制
- 批准号:
10678249 - 财政年份:2020
- 资助金额:
$ 4.68万 - 项目类别:
High-Throughput Dried Blood Spot (HT-DBS) Technologies in SARS COV-2 Serology and Vaccinology
SARS COV-2 血清学和疫苗学中的高通量干血斑 (HT-DBS) 技术
- 批准号:
10688352 - 财政年份:2020
- 资助金额:
$ 4.68万 - 项目类别:
Lyme Disease: B cell epitope discovery and mechanisms of antibody protection
莱姆病:B 细胞表位发现和抗体保护机制
- 批准号:
10021076 - 财政年份:2019
- 资助金额:
$ 4.68万 - 项目类别:
Lyme Disease: B cell epitope discovery and mechanisms of antibody protection
莱姆病:B 细胞表位发现和抗体保护机制
- 批准号:
10912412 - 财政年份:2019
- 资助金额:
$ 4.68万 - 项目类别:
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