In vivo Organ of Corti Mechanoelectric Physiology

体内柯蒂氏器官机电生理学

• 批准号: 9265812
• 负责人: Anders Fridberger
• 金额: $ 34.85万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-04-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9265812
• 关键词: Acoustic Nerve; Action Potentials; Address; Animal Model; Apical; Area; Auditory; Auditory Physiology; Automobile Driving; Basilar Membrane; Cavia; Cells; Cochlea; Cochlear Implants; Code; Complex; Data; Development; Event; Fiber; Frequencies; Generations; Gerbils; Goals; Hair; Hair Cells; Hearing; Human; In Vitro; Inner Hair Cells; Laboratories; Labyrinth; Lead; Learning; Liquid substance; Measurement; Measures; Mechanical Stimulation; Mechanics; Mediating; Methodology; Methods; Morphologic artifacts; Motion; Nerve Fibers; Neurosciences; Optical Coherence Tomography; Optics; Organ; Organ of Corti; Outer Hair Cells; Phase; Physiology; Process; Pump; Research; Research Personnel; Role; Sensory; Signal Transduction; Site; Spatial Distribution; Speech; Speech Perception; Stimulus; Structure; System; Techniques; Testing; Travel; Variant; base; capsule; comparative; design; hearing impairment; in vivo; innovation; interest; mathematical model; minimally invasive; prevent; public health relevance; response; sound; sound frequency; tectorial membrane; theories; tomography; vibration

 DESCRIPTION (provided by applicant): A goal of the cochlear physiology laboratory is to understand how the components of the organ of Corti enhance the sound induced vibration of the basilar membrane, a process known as cochlear amplification (CA). Two questions of broad interest are to be studied; how do the outer hair cells transmit force to activate the CA and what is the mechanical role of the tectorial membrane in CA? Standard techniques are clearly insufficient for answering these questions, so new and innovative methodology will be used. The Fourier Domain Optical (Low) Coherence Tomography (FDOCT) system that we developed gives unique possibilities for studying CA. Using this method; we propose to determine how the complex motion of the organ of the Corti, powered by OHC forces, results in mechanical stimulation of the inner hair cell stereocilia. This is the critical first step in hearing, the stiulation of inner hair cells. We also propose to determine whether the tectorial membrane has a mechanical resonance relevant to organ of Corti function. This is fundamental to understanding how the displacement of the stereocilia hair bundles on outer hair cells can have the proper timing to make effective any force that they actively produce. The distribution of outer hair cell activity is fundamental to knowing how the traveling wave propagates. The spatial distribution of the CA is studied with FDOCT and mathematical modeling.

 描述（由申请人提供）：耳蜗生理学实验室的目标是了解柯蒂氏器的组成部分如何增强基底膜的声音诱发振动，这一过程称为耳蜗放大（CA）。有两个广泛关注的问题需要研究；外毛细胞如何传递力来激活 CA？盖膜在 CA 中的机械作用是什么？标准技术显然不足以回答这些问题，因此将使用新的创新方法。我们开发的傅立叶域光学（低）相干断层扫描 (FDOCT) 系统为研究 CA 提供了独特的可能性。使用这种方法；我们建议确定由 OHC 力驱动的柯蒂氏器的复杂运动如何导致内毛细胞静纤毛的机械刺激。这是听力的关键第一步，即内毛细胞的刺激。我们还建议确定盖膜是否具有与柯蒂功能器官相关的机械共振。这对于理解外毛细胞上的静纤毛毛束的位移如何能够有适当的时机以使其主动产生的任何力发挥作用至关重要。外毛细胞活动的分布对于了解行波如何传播至关重要。利用 FDOCT 和数学建模研究了 CA 的空间分布。