TOPIC 342 - PHASE II CONTRACT - VALIDATION OF SHADE A MOBILE TECHNOLOGY FOR MONITORING OF ULTRAVIOLET EXPOSUREPOP - 1/20/2017 - 1/19/2019

Shade帮助人们管理他们的紫外线暴露--它是一种精确到无与伦比的紫外线(UV)监测器 已连接到移动应用程序。尽管紫外线是最明显和最可控的致癌原因之一，但由于结合了许多快速变化的因素的重要性，包括强度、阴影以及保护性凝块和防晒霜的使用，紫外线暴露可能很难估计。为了验证Shade在一项简短的研究中的有效性，我们招募了一组高度敏感的人群，即服用免疫抑制药物的移植患者。肾移植患者患鳞状细胞癌(SCC)的风险是后者的65倍，一旦确诊，他们发生转移和死亡的几率要高得多。鳞状细胞癌发生于癌前病变，紫外线引发的光化性角化病，这是一种在这一人群中发病率非常高的病变。 该项目将完成以下工作：(1)招募接受定期皮肤检查的移植患者，(2)为他们提供Shade，(3)通过皮肤科医生对光化性角化病的观察，以及通过减少UV暴露的生物标志物环丁烷嘧啶二聚体，来验证Shade使用者是否看到紫外线暴露的症状和标志物的减少，以及(4)通过 在研究开始和结束时完成紫外线教育调查。

Shade helps people manage their UV exposure_ it is a ultraviolet (UV) monitor with unprecidented accuracy connected to a mobile application. Although it is one of the clearest and most controllable causes of cancer, UV exposure can be difficult to estimate due to the importance of combining many rapidly changing factors including intensity, shade, and use of protective cloting and sunscreen. To validate Shade in a short study we enroll a highly susceptable population, transplant patients taking immunosupressive drugs. Kidney tranplant patients have 65 times higher risk for developing squamous cell carcinoma (SCC), and once diagnosed they have a far higher rate of developing metasteses and dying. SCC develops from precancerous, UV triggered actinic keratosis, a lesion with remarkably high prevalence in this population. This project will accomplish the following (1) recruit transplant patients undergoing regular skin checks, (2) provide them with Shade, (3) validate that Shade users see a decrease in symptoms and markers of UV exposure by dermatologist observation of actinic keratosis, and by a reduction in cyclobutane pyrimidine dimers a biomarker of UV exposure, and (4) observe changes in understanding of UV exposure through completion of a UV education survey at the beginning and end of the study.