TOPIC 342 - PHASE II CONTRACT - VALIDATION OF SHADE A MOBILE TECHNOLOGY FOR MONITORING OF ULTRAVIOLET EXPOSUREPOP - 1/20/2017 - 1/19/2019

主题 342 - 第二阶段合同 - 用于监测紫外线暴露的 SHADE A 移动技术的验证 - 1/20/2017 - 1/19/2019

• 批准号: 9539090
• 负责人: EMMANUEL DUMONT
• 金额: $ 149.41万
• 依托单位: YOUV LABS, INC.
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-01-20 至 2019-01-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9539090
• 关键词: Actinic keratosis; Anxiety; Basal cell carcinoma; Biological Markers; Cancer Etiology; Car Phone; Characteristics; Clinical; Clinical Research; Coagulation Process; Computers; Contracts; DNA Damage; Dermatologist; Devices; Diagnosis; Education; Enrollment; Enzyme-Linked Immunosorbent Assay; Goals; Health; High Prevalence; Histology; Individual; Information Systems; Kidney; Lesion; Measurement; Measures; Mental Depression; Mental Health; Minor; Monitor; Outcome; Patient Outcomes Assessments; Patients; Pharmaceutical Preparations; Population; Premalignant; Public Health; Pyrimidine Dimers; Quality of life; Recruitment Activity; Research Design; Role; Skin; Skin Carcinoma; Squamous cell carcinoma; Sunscreening Agents; Surveys; Symptoms; System; Technology; Testing; Therapeutic immunosuppression; Time; Transplant Recipients; UV Radiation Exposure; UV induced; Validation; Work; cancer prevention; experience; high risk; keratinocyte; mobile application; mobile computing; patient population; portability; sensor; skin cancer prevention; skin squamous cell carcinoma; social; tool; ultraviolet

Shade helps people manage their UV exposure_ it is a ultraviolet (UV) monitor with unprecidented accuracy connected to a mobile application. Although it is one of the clearest and most controllable causes of cancer, UV exposure can be difficult to estimate due to the importance of combining many rapidly changing factors including intensity, shade, and use of protective cloting and sunscreen. To validate Shade in a short study we enroll a highly susceptable population, transplant patients taking immunosupressive drugs. Kidney tranplant patients have 65 times higher risk for developing squamous cell carcinoma (SCC), and once diagnosed they have a far higher rate of developing metasteses and dying. SCC develops from precancerous, UV triggered actinic keratosis, a lesion with remarkably high prevalence in this population. This project will accomplish the following (1) recruit transplant patients undergoing regular skin checks, (2) provide them with Shade, (3) validate that Shade users see a decrease in symptoms and markers of UV exposure by dermatologist observation of actinic keratosis, and by a reduction in cyclobutane pyrimidine dimers a biomarker of UV exposure, and (4) observe changes in understanding of UV exposure through completion of a UV education survey at the beginning and end of the study.

Shade 帮助人们管理紫外线照射 - 它是一款具有前所未有的准确度的紫外线 (UV) 监测器 连接到移动应用程序。尽管紫外线是最明显、最可控的癌症原因之一，但由于结合许多快速变化的因素（包括强度、阴影以及防护服和防晒霜的使用）的重要性，紫外线暴露可能很难估计。为了在一项短期研究中验证 Shade，我们招募了高度易感人群，即服用免疫抑制药物的移植患者。肾移植患者患鳞状细胞癌 (SCC) 的风险高出 65 倍，而且一旦确诊，他们发生转移和死亡的几率要高得多。鳞状细胞癌由癌前紫外线引发的光化性角化病发展而来，这种病变在该人群中发病率非常高。 该项目将实现以下目标：(1) 招募接受定期皮肤检查的移植患者，(2) 为他们提供 Shade，(3) 通过皮肤科医生对光化性角化病的观察，以及通过减少环丁烷嘧啶二聚体（紫外线暴露的生物标志物）来验证 Shade 用户看到的症状和紫外线暴露标记物的减少，以及 (4) 通过以下方式观察对紫外线暴露的理解的变化： 在研究开始和结束时完成紫外线教育调查。