Core A - Bioinformatics Core

核心 A - 生物信息学核心

基本信息

批准号：
9209392
负责人：
JEFFREY P. BOND
金额：
$ 11.48万
依托单位：
UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-09-03 至 2022-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9209392
关键词：
Address Base Excision Repairs Biochemical Biochemistry Bioinformatics Biological Biological Models Catalysis Cell Proliferation Cell Survival Cell model Cellular biology Clinical Collection Communication Complex Computer software DNA Damage DNA Repair DNA Repair Enzymes DNA Repair Gene DNA Sequence DNA Sequence Alteration Data Data Sources Databases Defect Development Documentation Enzyme Kinetics Equipment and supply inventories Evaluation Event Experimental Designs Frequencies Genes Genetic Variation Genome Genomics Goals Health High Performance Computing Human Human Genetics Human Resources Informatics Knowledge Laboratories Laboratory Study Large-Scale Sequencing Link Logistics Malignant Neoplasms Manuals Medicine Modeling Molecular Molecular Biology Mus OGG1 gene Oncogenes POLB gene Pathway interactions Phenotype Population Positioning Attribute Post-Translational Protein Processing Pre-Clinical Model Process Program Research Project Grants Proteins Publications Reporting Research Infrastructure Role Sampling Service Statistics Services Somatic Mutation Statistical Data Interpretation Structure System Systems Biology Testing The Cancer Genome Atlas Therapeutic Time Transgenic Mice Variant Work XRCC1 gene base cancer therapy carcinogenesis chemotherapy computerized tools data management design experimental analysis experimental study meetings member molecular sequence database multidisciplinary novel predicting response predictive marker programs protein function protein structure repair enzyme single molecule statistical service statistics synergism tumor

项目摘要

SUMMARY – CORE A The four research projects of the Program Project propose laboratory characterization of the consequences of genetic variation for carcinogenesis and cancer therapy. These studies are focused on genes involved in Base Excision Repair (BER). Genetic variation will include germline and somatic variation. Core A will provide informatics and statistics support for these experiments. Core A personnel have expertise in bioinformatics, systems biology, statistics, process management, and high performance computing. Dr. Bond has worked with the P01 since its inception. Aim 1 (Informatics) Identify variants for functional studies. A central role of Core A is to support identification of variants, for experimental studies, that are expected to have consequences for protein function. These variants are identified using DNA sequences available from large- scale sequence projects such as the 1000 Genomes Project and The Cancer Genome Atlas. Core A annotates the variants using publicly available software. Core A (Drs. Bond and Dragon) host weekly meetings at which these variants are presented and discussed. These meetings provide consistent communications with members of the four projects. Aim 2 (Statistics) Provide software and statistical support for hypothesis tests. The laboratory studies proposed in Projects 1-4 will characterize the consequences of this variation for protein structure, interactions, damage search and catalysis as well as cellular proliferation and survival. Core A statistical services will support design and analysis of these experiments.

摘要 - 核心A 计划项目建议实验室的四个研究项目的后果表征致癌和癌症治疗的遗传变异。这些研究的重点是与基础有关的基因切除维修（BER）。遗传变异将包括种系和体细胞变异。核心A将提供信息和统计数据支持这些实验。核心人员在生物信息学方面具有专业知识，系统生物学，统计，过程管理和高性能计算。邦德博士与 P01自成立以来。 AIM 1（信息学）确定功能研究的变体。一个核心角色核心A是支持变体的识别，用于实验研究，预计将具有蛋白质功能的后果。这些变体是使用大型可用的DNA序列确定的比例序列项目，例如1000个基因组项目和癌症基因组图集。核心A。使用公开可用的软件注释变体。核心A（博士和龙）主持人每周会议在其中提出和讨论了这些变体。这些会议提供了与四个项目的成员。 AIM 2（统计）为假设提供软件和统计支持测试。项目1-4中提出的实验室研究将表征这种差异的后果蛋白质结构，相互作用，损害搜索和催化以及细胞增殖和存活。统计服务将支持这些实验的设计和分析。