Psychotherapy Research Center: SOBC Admin Supplement: Targeting self-regulatory deficits through cognitive remediation intervention

总括 摘要 我们寻求更新我们的心理治疗发展研究中心(PDC)，致力于发展， 评估和传播有效的治疗方法，并围绕行为模式的阶段组织 治疗的发展(Rounaville，Carroll&Onken，2001)。该中心的目标是(1)加速 通过翻译方法开发行为疗法的进展和(2)提供 其他环境下的治疗开发工作的模式和资源。通过强调科学的 行为研究的进展，我们的目标是促进发展和有效实施 尽可能最有效的行为干预，并了解它们如何通过瞄准核心来发挥其影响 上瘾的过程。PDC由一个致力于科学研究的研究/管理核心组成 协调，向组成部分项目提供集中服务，支持试点第一级项目， 培训新的调查员和技术转让，以及三个单独的组成部分。在续签期间 在此期间，核心工作人员将监督一项雄心勃勃的试点研究计划，并提供科学监督、管理、 对中心项目的核心评估和技术援助，以及咨询和 向其他地点的调查人员和临床医生提供协助。这三个部分将评估1：认知 控制训练以提高CBT4CBT，2.通过适应性的后续护理扩大治疗效果 3、评价短期训练对渴求调节及其神经机制的影响 我们仍然是NIDA唯一致力于开发、测试和传播行为疗法的中心。 在过去四年的支持中，我们成功地实现了我们三个组成部分项目的具体目标， 开展了12个试点项目，出版了近400份出版物。我们曾担任过地方、国家和 关于成瘾治疗的国际资源，为88名受训人员和 初级教员，以及对数千名临床医生进行的循证治疗培训。我们带来了两个 起源于中心试点、低成本强化干预和计算机化的治疗 认知行为疗法(CBT4CBT)到被广泛认可为经验性验证的程度 治疗并在大型服务提供系统中实施。我们培育了多元化发展。 治疗青少年吸烟的独立卫星方案、以技术为基础的干预、培训 研究和传播并减少吸毒人群中的艾滋病毒危险行为。我们已经整合了 神经成像到组件试验中，产生了关于治疗结果和神经相关性的丰富数据 治疗如何有效地改变神经生物学过程。我们已经广泛地提供了这些数据 通过建立神经信息学数据库和储存库。

Overall ABSTRACT We seek to renew our Psychotherapy Development Research Center (PDC) dedicated to the development, evaluation and dissemination of effective therapies and organized around the Stage Model of behavioral therapies development (Rounsaville, Carroll & Onken, 2001). The goals of this Center are to (1) accelerate progress in the development of behavioral therapies through a translational approach and (2) to provide a model and resource for therapy development efforts in other settings. By emphasizing the scientific progression of behavioral research, our aims are to foster development and effective implementation of the most potent behavioral interventions possible and to understand how they exert their effects by targeting core processes of addiction. The PDC consists of a Research/Administrative Core devoted to scientific coordination, provision of centralized services to component projects, support for pilot Stage I level projects, training of new investigators and technology transfer, and three individual components. During the renewal period, core staff will oversee an ambitious pilot study program and provide scientific oversight, administration, a core battery of assessments, and technical assistance to center projects along with consultation and assistance to investigators and clinicians at other sites. The three components will evaluate 1: Cognitive control training to enhance CBT4CBT, 2. Extending treatment effects through an adaptive aftercare intervention, and 3, evaluating brief training in regulation of craving and its neural mechanisms We remain NIDA's only Center dedicated to the developing, testing, and dissemination of behavioral therapies. In the past 4 years of support, we have successfully met the Specific Aims of our 3 component projects, conducted 12 pilot projects, and generated almost 400 publications. We have served as a local, national, and international resource on addiction treatment, providing research training and mentoring to 88 trainees and junior faculty, as well as training in evidence based therapies to thousands of clinicians. We have brought two therapies which had their origins as Center pilots, low cost reinforcement interventions and computerized cognitive behavioral therapy (CBT4CBT) to the point where they are widely recognized as empirically validated treatments and implemented in large service delivery systems. We have fostered the development of multiple independent satellite programs in treatment of adolescent smoking, technology based interventions, training studies and dissemination and reducing HIV risk behaviors in drug using populations. We have integrated neuroimaging into component trials, yielding a wealth of data on neural correlates of treatment outcome and how effective treatments may change neurobiological processes. We have made these data widely available through establishing a neuroinformatics database and repository.