Identification of a Meaningful Cocaine Use Outcome Measure

确定有意义的可卡因使用结果衡量标准

基本信息

  • 批准号:
    9750045
  • 负责人:
  • 金额:
    $ 37.16万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-09-15 至 2021-08-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY/ABSTRACT The identification of a valid and meaningful indicator of a successful outcome from the treatment of cocaine use disorders has been hindered by the lack of an association between reductions in cocaine use and a functional outcome measure that is sensitive to change. This R21/33 proposal submitted in response to NIDA Funding Opportunity PA-15-099 (Reductions in Illicit Drug Use and Functional Outcomes), seeks to address this issue by pooling data across 13 clinical trials of treatments for cocaine use disorders and using the dataset to empirically derive a new instrument for measuring functional outcomes that is sensitive to change. This new measure will be used to identify and validate changes in cocaine use that are associated with improvement in functional outcomes. The specific aims of each phase of this proposal are as follows: R21 Phase: 1. Create a large pooled database of more than 2,000 unique cocaine dependent individuals participating in one of 13 clinical trials conducted at Yale and the University of Connecticut. In all trials, measures of cocaine use were collected by both self-report and urine drug screens at least weekly during treatment, as well as during a 6- to 12-month follow-up period (>80% data availability). 2. Conduct an integrative data analysis to empirically derive a new measure of functioning covering a broad range of domains (e.g., mental health, physical health, criminality/legal problems, employment) that is psychometrically sensitive to change. R33 Phase: 1. We will determine the levels of change on the developed functional outcome measure from pre-treatment through follow-up period that correspond to cocaine use trajectories identified through latent growth mixture models. This will establish whether improvements in functioning are associated with `reduction'-based cocaine use patterns. 2. Validate the relationship between cocaine use patterns and functional outcomes using two reserved trials within the pooled data (n=442 and 358, respectively) to replicate the levels of change on functional outcomes corresponding to various cocaine use trajectories. This rich database will allow us to capitalize on advanced psychometric and statistical methods to produce a functional outcome measure that would be of high scientific and clinical utility, as well as provide a level of evidence to support non-abstinence measures of cocaine use as a meaningful outcome for clinical trials.
项目总结/文摘

项目成果

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KATHLEEN M. CARROLL其他文献

KATHLEEN M. CARROLL的其他文献

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{{ truncateString('KATHLEEN M. CARROLL', 18)}}的其他基金

Research Core Psychotherapy Devleopment Research Center
研究核心 心理治疗发展研究中心
  • 批准号:
    8742765
  • 财政年份:
    2014
  • 资助金额:
    $ 37.16万
  • 项目类别:
Administrative Core Psychotherapy Development Research Center
行政核心心理治疗发展研究中心
  • 批准号:
    8742764
  • 财政年份:
    2014
  • 资助金额:
    $ 37.16万
  • 项目类别:
Project#1: Cognitive Control Training to Enhance CBT4CBT
项目
  • 批准号:
    8742766
  • 财政年份:
    2014
  • 资助金额:
    $ 37.16万
  • 项目类别:
Neural mechanisms of CBT in cocaine dependence
可卡因依赖中 CBT 的神经机制
  • 批准号:
    8914560
  • 财政年份:
    2013
  • 资助金额:
    $ 37.16万
  • 项目类别:
Neural mechanisms of CBT in cocaine dependence (Gender Differences Supplement)
可卡因依赖中 CBT 的神经机制(性别差异补充)
  • 批准号:
    8803086
  • 财政年份:
    2013
  • 资助金额:
    $ 37.16万
  • 项目类别:
Neural mechanisms of CBT in cocaine dependence
可卡因依赖中 CBT 的神经机制
  • 批准号:
    8731378
  • 财政年份:
    2013
  • 资助金额:
    $ 37.16万
  • 项目类别:
Neural mechanisms of CBT in cocaine dependence
可卡因依赖中 CBT 的神经机制
  • 批准号:
    8534513
  • 财政年份:
    2013
  • 资助金额:
    $ 37.16万
  • 项目类别:
Neural mechanisms of CBT in cocaine dependence
可卡因依赖中 CBT 的神经机制
  • 批准号:
    8708818
  • 财政年份:
    2013
  • 资助金额:
    $ 37.16万
  • 项目类别:
Computer Based Training in CBT for Spanish-Speaking Substance Users
为西班牙语药物使用者提供基于计算机的 CBT 培训
  • 批准号:
    9231403
  • 财政年份:
    2012
  • 资助金额:
    $ 37.16万
  • 项目类别:
A Stage I Study of Computer Based Training in CBT for Alcohol Use Disorders
基于计算机的酒精使用障碍 CBT 培训的第一阶段研究
  • 批准号:
    8503575
  • 财政年份:
    2012
  • 资助金额:
    $ 37.16万
  • 项目类别:

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