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Preclinical Evaluation Of Neutralizing Antibodies Elicited by HIV-1 Immunogens

Preclinical Evaluation Of Neutralizing Antibodies Elicited by HIV-1 Immunogens
HIV-1 免疫原引发的中和抗体的临床前评估
批准号：
9564619
负责人：
John Mascola
金额：
$203.19万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/9564619
关键词：
AnimalsAntibodiesAntibody ResponseAntibody titer measurementAntigensDNAEpitopesGlycoproteinsHIVHIV-1ImmunizationMacaca mulattaMapsProteinsRegimenStandardizationStructureTestingTransgenic MiceVaccinesbasemouse modelneutralizing antibodynovelplasmid DNApreclinical evaluationrecombinant adenovirus

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中文摘要
翻译
本研究考察了小动物和恒河猴在不同免疫方案后中和抗体反应的广度和幅度。使用标准化的多层参考Env假病毒面板进行中和抗体评估，我们发现蛋白质免疫和DNA引物（rAd增强免疫）都可以产生高抗体滴度。目前正在进行的研究正在评估基于HIV-1包膜糖蛋白研究中基于结构的信息的新型免疫原。利用新的转基因小鼠模型，可以基于我们先前对HIV中和抗体结构和功能的研究来测试免疫原策略。
英文摘要
The present studies examine the breadth and magnitude of neutralizing antibody responses in small animals and rhesus monkeys after various immunization regimens. Using a standardized multi-tier panel of reference Env pseudoviruses for neutralizing antibody assessment, we show that both protein immunization, and DNA prime, rAd boost immunization, can generate high antibody titers. Ongoing studies are evaluating novel immunogens based on structure-based information from studies of the HIV-1 envelope glycoprotein. The use of novel transgenic mouse models allows testing of immunogen strategies based on our previous studies of HIV neutralizing antibody structure and function.
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会议论文
Next Generation Development of Broadly Neutralizing HIV Antibodies for Prevention
HIV/AIDS Vaccine and Antibody Development
Pre-clinical Vaccine Development for Respiratory Viruses
Pre-clinical Vaccine and Antibody Development for Coronavirus Disease 2019 (COVID-19)
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