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Behavioral and Neural Outcomes of a New Executive Function Treatment for Transition-Age Youth with ASD

新的执行功能治疗对患有自闭症谱系障碍的过渡年龄青少年的行为和神经结果

基本信息

批准号：
9313935
负责人：
Cara Pugliese
金额：
$ 15.61万
依托单位：
CHILDREN'S RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-07-11 至 2020-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9313935
关键词：
Adult Affect Aftercare Age Anterior Anxiety Attention Attention deficit hyperactivity disorder Autistic Disorder Award Behavior Behavioral Benchmarking Biological Markers Brain Caring Child Clinic Cognitive Collaborations Communities Competence Control Groups Data Development Developmental Disabilities Disease Effectiveness Evidence based treatment Executive Dysfunction Expert Opinion Failure Feedback Fellowship Foundations Functional Magnetic Resonance Imaging Future Goals High School Student Home environment Impairment Individual Intellectual functioning disability Intervention Intervention Studies Investigation K-Series Research Career Programs Laboratories Life Link Manuals Measurement Measures Mental Retardation and Developmental Disabilities Research Centers Mental disorders Mentors Mentorship Methodology Methods Modeling National Institute of Mental Health Neuropsychology Outcome Outcome Measure Outcomes Research Participant Phenotype Pilot Projects Population Prefrontal Cortex Problem Solving Problem behavior Process Regulation Research Research Domain Criteria Research Personnel Rest Risk Running Schools Science Solid Structure Students Subgroup Symptoms Testing Training Treatment outcome United States Work Youth aged attentional control autism spectrum disorder base career causal model cingulate cortex college community intervention cost design developmental disease effectiveness trial elementary school executive function experience flexibility follow-up health care availability high school i(19)implementation science improved innovation insight multidisciplinary neural correlate neuroimaging novel patient oriented personalized intervention post intervention productivity loss psychologic relating to nervous system segregation skills skills training social skills therapy development trial comparing university student

项目摘要

PROJECT SUMMARY Autism Spectrum Disorders (ASD) affect 1 in 88 children in the United States. Individuals without intellectual disabilities comprise the fastest-growing subgroup of ASD and account for two-thirds of the total population. Impaired executive functions (EF) occur as a result of abnormal prefrontal cortex function and are related to poor adult outcome. EF problems are pivotal targets for intervention because they are common, linked to independence, and responsive to treatment. The proposed study will test the effectiveness of a school-based cognitive behavioral EF intervention, called Flexible Futures (FF), for college-bound youth with ASD and evaluate the neural correlates of treatment outcome. FF is a targeted, phenotype-specific intervention focused on the domains of EF that are most impaired in ASD – flexibility and planning skills. This K23 Mentored Patient-Oriented Career Development Award application is to request support for the candidate's development as an independent investigator specializing in the development and implementation of innovative interventions personalized for specific cognitive profiles that are transportable for mass usage in school-settings. This K23 Mentored Patient-Oriented Career Development Award will provide focused research experience and theoretical training in the development of evidence-based treatments that support transition to adulthood in ASD. The award will also provide training and experience in the investigation of neural predictors and correlates of treatment outcome using neuroimaging methods. In accordance with these goals, the training aims of this proposal are to: 1) develop an understanding of causal models of developmental disabilities and expertise in measurement of key outcomes at the behavioral, cognitive, and neural levels; 2) acquire expertise in the development of treatments for transition-age youth within the school setting; and 3) gain competencies in the methodology, design, and implementation science of pragmatic community-partnered effectiveness trials. The proposed research aims for this project are to: 1) refine the treatment manual for Flexible Futures and test its acceptability, feasibility, and effectiveness in a school setting, 2) identify neural correlates of treatment change using fMRI, and 3) identify biomarkers of EF outcomes at the behavioral, cognitive, and neural level. The treatment manual will be iteratively refined with input from experts in the field of ASD research and tested for effectiveness against a social skills intervention within an educational setting. Flexible Futures is anticipated to result in changes at the behavioral, cognitive, and neural level. Specifically, it is hypothesized that participants in Flexible Futures will demonstrate greater gains in flexibility and planning compared to those in social skills treatment. Significant changes in behavior and brain activity as a result of Flexible Futures could have profound implications for the development and refinement of psychological treatments for ASD.

项目总结