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The Effects of Electronic Cigarette Use on Alcohol Consumption: A Neurocognitive and Behavioral Investigation

使用电子烟对饮酒的影响：神经认知和行为研究

基本信息

批准号：
9350148
负责人：
Alexandra Hershberger
金额：
$ 4.24万
依托单位：
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-06-01 至 2018-05-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): This project proposes to examine how electronic-cigarettes (e-cigs) influence alcohol use in a well-controlled laboratory setting. My overarching models proposes that 1) e-cig use results in attentional bias towards alcohol cues, 2) e-cig use results in increased alcohol consumption, and 3) these behavioral and neurocognitive patterns relate to self-reported concurrent alcohol and e-cig use, as well as self-report cravings for e-cig and alcohol. Although a relationship between e-cig use and alcohol consumption is supported by cross-sectional data [1-4], research has yet to experimentally examine my overarching model by which e-cig use influences neurocognitive and behavioral responses affecting alcohol consumption. The proposed study will use an eye-tracking dot-probe task, an ad libitum oral alcohol consumption paradigm, behavioral tracking of e-cig puffs and alcohol sips, self- report alcohol and e-cig use measures, and self-report craving measures to assess my integrative model. The main study hypotheses are: 1) Individuals primed with e-cig use will display a larger attentional bias towards alcohol cues, as assessed with eye-tracking measurement during a dot probe task, as compared to when there is no e-cig prime, 2) the strength of the attentional bias for alcohol cues following e-cig prime will be related to self-reported concurrent alcohol and e-cig use as measured by a timeline follow-back and self-reported e-cig and alcohol craving, 3) individuals will consume more alcohol ad libitum when allowed to use e-cigs during the session as compared to when e-cig use is not allowed, 4) the amount of alcohol consumed during the ad libitum session will be significantly related to the amount of e-cig use during the ad libitum session, and 5) the effect of e-cig use on alcohol consumption will be related to self-reported concurrent alcohol and e-cig use as measured by a timeline follow-back and self-reported e-cig and alcohol craving. Given that e-cigs are often marketed for health related benefits, including smoking cessation, and that they are used to circumvent comprehensive smoking bans, experimentally examining how e-cig use affects alcohol consumption is imperative. E-cigs could cause unintended harm to individuals by increasing alcohol consumption. Successfully demonstrating this effect will help advance the field and further inform health care providers concerning the safety and potential inadvertent negative consequences of e-cig use.

描述(由申请者提供)：该项目建议在受控良好的实验室环境中研究电子烟(e-cig)如何影响酒精使用。我的主要模型认为，1)使用电子烟会导致对酒精暗示的注意力偏向，2)使用电子烟会导致酒精消耗量增加，3)这些行为和神经认知模式与自我报告的同时使用酒精和电子烟，以及自我报告对电子烟和酒精的渴望有关。尽管横截面数据[1-4]支持了电子烟使用和酒精消费之间的关系，但研究还没有对我的主要模型进行实验检验，即电子烟使用影响影响酒精消费的神经认知和行为反应。这项拟议的研究将使用眼球跟踪点探测任务、即兴口服酒精消费范式、电子烟泡芙和饮酒行为跟踪、自我报告酒精和电子烟使用指标以及自我报告渴望指标来评估我的综合模型。主要的研究假设是：1)与没有电子CIG时相比，在点探测任务期间通过眼球跟踪测量来评估，使用电子CIG的个体对酒精提示表现出更大的注意偏差；2)在电子CIG开始之后对酒精提示的注意偏差的强度将与通过时间线跟踪和自我报告的E-CIG使用和酒精渴望来测量的自我报告的同时饮酒和E-CIG的使用有关；3)与不允许使用E-CIG时相比，当允许在会话期间使用E-CIG时，个人将临时消费更多的酒精，4)临时会议期间的饮酒量将与临时会议期间电子烟的使用量显著相关，以及5)电子烟的使用对酒精消费的影响将与自我报告的同时饮酒和电子烟的使用有关，通过时间线跟踪和自我报告的电子烟和酒精渴望来衡量。鉴于电子烟的销售往往是为了与健康相关的好处，包括戒烟，而且它们被用来规避全面的禁烟令，因此通过实验研究电子烟的使用如何影响酒精消费是当务之急。电子烟可能会增加饮酒量，从而对个人造成意外伤害。成功地展示这一效应将有助于推动这一领域的发展，并进一步向卫生保健提供者通报使用电子烟的安全性和潜在的无意负面后果。