Cincinnati Regional Coordinating Stroke Center (Cincinnati RCC)

描述（由申请人提供）：拟议的 NINDS 中风临床试验网络 (NSTN) 的目标是利用多学科中风专业知识来协作、高效地设计和执行所有阶段的中风临床试验。作为 NSTN 的区域协调中心 (RCC)，我们将采用完全集成的临床试验网络方法，以更广泛、更团结的方式治疗中风。我们的目标是 (1) 作为 RCC 有效实施试验、招募和留住参与者并优化数据质量，(2) 作为经验丰富的科学家、临床医生、试验人员和协调员积极参与 NSTN，以及 (3) 成功培训 下一代中风临床试验者。我们将通过提供经验丰富的领导、接触多样化患者群体、完善的研究基础设施和支持性管理来实现这些目标。我们的机构同意使用标准化主试验协议、采用集中 IRB 审查并提供额外的机构资金来支持 RCC 实习生，从而表明了对 NSTN 的承诺。我们提议成为 NSTN 的重要合作伙伴，致力于通过高质量的中风试验为我们的患者带来最具临床影响力的中风疗法。

DESCRIPTION (provided by applicant): The objectives of the proposed NINDS Stroke Clinical Trials Network (NSTN) are to harness multidisciplinary stroke expertise to collaboratively and efficiently design and execute stroke clinical trials in all phases. We will bring a fully integratd clinical trial network approach to stroke more broadly and cohesively as a Regional Coordinating Center (RCC) of the NSTN. Our goals are to (1) efficiently implement trials, recruit and retain participants, and optimize data quality as an RCC, (2) actively participate in the NSTN as experienced scientists, clinicians, trialists, and coordinators, and (3) successfully train the next generation of stroke clinical trialists. We will achieve these goals by bringing experienced leadership, access to a diverse patient population, an established research infrastructure, and a supportive administration. Our institution has shown their commitment to the NSTN by agreeing to use a standardized Master Trial Agreement, employ a centralized IRB review, and provide additional institutional funds to support the RCC trainee. We propose to be a key partner in the NSTN working to bring the most clinically impactful stroke therapies to our patients through high-quality stroke trials.