The effect of insufficient sleep on cardiovascular disease disparity between blacks and whites

睡眠不足对黑人和白人心血管疾病差异的影响

• 批准号: 9228453
• 负责人: Azizi Seixas
• 金额: $ 17.98万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-01-15 至 2020-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9228453
• 关键词: Address; Adult; Advisory Committees; Affect; Age; Area; Bayesian Analysis; Bayesian Modeling; Biological; Blood Pressure; Body mass index; Cardiac health; Cardiovascular Diseases; Cardiovascular system; Caring; Cholesterol; Cohort Studies; Complex; Data; Data Analyses; Development; Disease Outcome; Environment; Epidemiology; Equation; Ethnic Origin; Failure; Fostering; Funding; Future; Glucose; Glucose Intolerance; Goals; Health Services Research; Hypertension; Intervention; K-Series Research Career Programs; Lead; Life Style; Link; Machine Learning; Mathematics; Mediating; Medical; Mentors; Mentorship; Methodology; Minority; Modeling; National Heart, Lung, and Blood Institute; Obesity; Obstructive Sleep Apnea; Physiology; Play; Population; Probability; Race; Recommendation; Reporting; Research; Research Personnel; Risk Factors; Risk Marker; Risk Reduction; Role; Science; Scientist; Site; Sleep; Sleep Apnea Syndromes; Sleep Disorders; Sleeplessness; Stroke; System; Training; Underserved Population; United States National Institutes of Health; Work; analytical method; base; cardiovascular disorder risk; cardiovascular health; comparative effectiveness; disparity reduction; effectiveness research; experience; fasting glucose; health disparity; innovation; laboratory experience; models and simulation; mortality; novel; pedagogical content; post stroke; prevent; racial disparity; secondary analysis; social health determinants; stroke survivor; symposium

Project Summary/Abstract Background: Blacks have higher rates of cardiovascular disease (CVD), CVD risk markers (elevated blood pressure, cholesterol, and unhealthy glucose levels), and CVD mortality, compared to whites. Despite advances in understanding how CVD disparity is engendered and preventing CVD, blacks compared to whites are still disproportionately burdened by CVD, particularly CVD risk markers. Therefore, more novel targets that drive racial disparity in CVD risk markers must be investigated in order to reduce and eliminate CVD disparity. Evidence indicating that insufficient sleep (sleep duration ≤6hrs/24 hr. cycle), which disproportionately affects blacks, is linked to concurrent and future CVD risk may offer a potentially novel mechanism explaining CVD risk disparity between blacks and whites. However, it is unclear whether insufficient sleep directly or indirectly drives disparity in CVD risk between blacks and whites? Therefore, the purpose of the proposed K01 study is to investigate whether insufficient sleep independently explains a significant portion of racial disparity in CVD risk markers, while adjusting for the confounding effects of sleep apnea and insomnia (two sleep disorders that cause insufficient sleep). Additionally, since 55% of insufficient sleepers are obese and blacks are twice as likely to be obese compared to whites, the candidate will investigate the independent and combined effects of insufficient sleep and obesity on the disparity in CVD risk markers between blacks and whites. Research: In the proposed K01, the candidate, Dr. Azizi Seixas, will investigate: 1) whether insufficient sleep and/or obesity play an important role in the relationship between race/ethnicity and CVD risk, controlling for sleep apnea and insomnia; and 2) what sleep duration and body mass index profile is associated with lowest probability of CVD risk among blacks and whites, using advanced mathematical analytic methods and complex system simulation modeling. Training: The training plan builds upon the candidate's background and experience in conducting research in sleep disorders and cardiovascular disease (e.g. hypertension and stroke), among minority populations. During the K01, the candidate will receive training in sleep science and physiology, cardiovascular disease and advanced analytical, machine learning, and simulation modeling. He will perform secondary analyses of data from the Sleep Heart Health Study, a NHLBI-funded study. The pedagogical approach includes one-on-one mentorship, course work, mentored laboratory training (practicum), and attendance to targeted conferences and seminars, with the common goal of supporting his transition to being an independent scientist.

项目摘要/摘要 背景：黑人患心血管疾病(CVD)、心血管疾病危险标记物(血液升高)的几率更高 与白人相比，压力、胆固醇和不健康的血糖水平)和心血管疾病死亡率。尽管 了解心血管疾病差异产生和预防心血管疾病的进展黑人与白人比较 仍然不成比例地背负着心血管疾病的负担，特别是心血管疾病风险标记。因此，更新颖的目标是 必须调查心血管疾病危险标记中的种族差异，以减少和消除心血管疾病差异。 有证据表明睡眠不足(睡眠持续时间≤6小时/24小时。周期)，这不成比例地影响 BLACKS与并发和未来的CVD风险有关，可能提供一种潜在的新机制来解释CVD 黑人和白人之间存在差距的风险。然而，目前还不清楚睡眠不足是直接还是间接的 导致黑人和白人患心血管疾病风险的差异？因此，拟议的K01研究的目的是 调查睡眠不足是否独立地解释了心血管疾病中种族差异的一个重要部分 风险标记物，同时调整睡眠呼吸暂停和失眠(两种睡眠障碍 导致睡眠不足)。此外，由于55%的睡眠不足者是肥胖者，黑人的肥胖率是 与白人相比，候选人很可能是肥胖者，他将调查 睡眠不足和肥胖对黑人和白人心血管疾病风险标记物的差异。 研究：在拟议的K01中，候选人Azizi Seixas博士将调查：1)睡眠不足 和/或肥胖在种族/民族与心血管疾病风险之间的关系中起着重要作用，控制 睡眠呼吸暂停和失眠；以及2)睡眠时间和身体质量指数与最低 黑人和白人心血管疾病风险的概率，使用先进的数学分析方法和复杂的 系统仿真建模。 培训：培训计划以应聘者在以下领域进行研究的背景和经验为基础 睡眠障碍和心血管疾病(如高血压和中风)在少数群体中占主导地位。在.期间 K01，候选人将接受睡眠科学和生理学、心血管疾病和 高级分析、机器学习和仿真建模。他将对数据进行二次分析 来自睡眠心脏健康研究，这是NHLBI资助的一项研究。教学方法包括一对一 指导、课程工作、有指导的实验室培训(实践)和参加有针对性的会议 和研讨会，共同的目标是支持他向独立科学家的转变。