SBHW-PREDICT (The role of PRoteomics, gEnetics, and Directed Imaging using CT)

SBHW-PREDICT(蛋白质组学、遗传学和 CT 定向成像的作用)

基本信息

  • 批准号:
    9264579
  • 负责人:
  • 金额:
    $ 65.59万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2015
  • 资助国家:
    美国
  • 起止时间:
    2015-07-15 至 2020-04-30
  • 项目状态:
    已结题

项目摘要

 DESCRIPTION (provided by applicant): In our proposed study, SBHW-PREDICT (The role of PRoteomics, gEnetics, and Directed Imaging using CT), we will assess whether identification of at-risk individuals, using imaging markers, a biomarker profile or a combination of the two, improves reclassification and discrimination over traditional risk factors, particularly in those wth either a family history of coronary heart disease (CHD) or higher genetic predisposition for CHD. We have used data from 1312 participants of the first NIH-funded study of predictive value of CAC, the South Bay Heart Watch (SBHW) study, to calculate plaque density. In preliminary analyses, we have found that higher plaque density is related to lower incidence of CVD events in this cohort. In the proposed study, we will use serum and cell samples collected at baseline, 20 years ago, from the SBHW and retrospectively assess outcomes using administrative data from Medicare and the National Death Index to address the following aims and objectives: 1) Using Medicare Claims and National Death Index data assess prognostic value of baseline CAC, as well as coronary calcium density for long-term (20 year) CHD event rate; 2) Using serum and cell samples collected at baseline, assess whether a multi-biomarker approach using circulating markers from different biological pathways would have additional reclassification value over traditional risk factors; 3) Determine whether compared to family history a CHD genetic risk score is more predictive of events; and 4) Determine whether a genetic score modifies the prognostic value of an imaging marker (CAC) or a multiple biomarker score or a combination of the two in those at higher predisposition (based on either family history or genetic score) for CHD versus those at low genetic risk. The experience of our multidisciplinary research team, unique 20 year follow-up period after baseline CAC, linkage to Medicare claims data and Death Index data, genetic and biomarker profiles using frozen serum and cell samples, and follow-up of the original cohort survivors are major strengths of this proposal. Results of thi project will assess the utility of a complementary genetic marker, multi-biomarker, and imaging approach to risk assessment.


项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Shaista Malik其他文献

Shaista Malik的其他文献

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{{ truncateString('Shaista Malik', 18)}}的其他基金

Neuroimmune mechanisms underlying electroacupuncture effect on vascular function
电针影响血管功能的神经免疫机制
  • 批准号:
    10470285
  • 财政年份:
    2021
  • 资助金额:
    $ 65.59万
  • 项目类别:
Neuroimmune mechanisms underlying electroacupuncture effect on vascular function
电针影响血管功能的神经免疫机制
  • 批准号:
    10316925
  • 财政年份:
    2021
  • 资助金额:
    $ 65.59万
  • 项目类别:
Neuroimmune mechanisms underlying electroacupuncture effect on vascular function
电针影响血管功能的神经免疫机制
  • 批准号:
    10693901
  • 财政年份:
    2021
  • 资助金额:
    $ 65.59万
  • 项目类别:
SBHW-PREDICT (The role of PRoteomics, gEnetics, and Directed Imaging using CT)
SBHW-PREDICT(蛋白质组学、遗传学和 CT 定向成像的作用)
  • 批准号:
    8946099
  • 财政年份:
    2015
  • 资助金额:
    $ 65.59万
  • 项目类别:
SBHW-PREDICT (The role of PRoteomics, gEnetics, and Directed Imaging using CT)
SBHW-PREDICT(蛋白质组学、遗传学和 CT 定向成像的作用)
  • 批准号:
    9109508
  • 财政年份:
    2015
  • 资助金额:
    $ 65.59万
  • 项目类别:
Image based cardiovascular risk communication in high risk patients with diabetes
基于图像的糖尿病高危患者心血管风险沟通
  • 批准号:
    8047712
  • 财政年份:
    2011
  • 资助金额:
    $ 65.59万
  • 项目类别:
Image based cardiovascular risk communication in high risk patients with diabetes
基于图像的糖尿病高危患者心血管风险沟通
  • 批准号:
    8213510
  • 财政年份:
    2011
  • 资助金额:
    $ 65.59万
  • 项目类别:
Image based cardiovascular risk communication in high risk patients with diabetes
基于图像的糖尿病高危患者心血管风险沟通
  • 批准号:
    8605066
  • 财政年份:
    2011
  • 资助金额:
    $ 65.59万
  • 项目类别:
Image based cardiovascular risk communication in high risk patients with diabetes
基于图像的糖尿病高危患者心血管风险沟通
  • 批准号:
    8426135
  • 财政年份:
    2011
  • 资助金额:
    $ 65.59万
  • 项目类别:
Image based cardiovascular risk communication in high risk patients with diabetes
基于图像的糖尿病高危患者心血管风险沟通
  • 批准号:
    8795750
  • 财政年份:
    2011
  • 资助金额:
    $ 65.59万
  • 项目类别:

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