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Brain Mechanisms Supporting Individual Differences in Pain

支持疼痛个体差异的大脑机制

基本信息

批准号：
9258510
负责人：
Robert C Coghill
金额：
$ 56.14万
依托单位：
CINCINNATI CHILDRENS HOSP MED CTR
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-07-01 至 2020-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9258510
关键词：
Acute Pain Address Affect American Anatomy Anxiety Attention Brain Brain imaging Brain region Communities Complex Corpus striatum structure Data Data Set Databases Development Disease Economics Ensure Environment Ethnic Origin Evaluation Exhibits Factor Analysis Functional Imaging Future Human Image Impulsive Behavior Impulsivity Income Individual Individual Differences Injury Insula of Reil Knowledge Link Magnetic Resonance Imaging Measures Mental Depression Mental Health Mental disorders Nociception Obesity Pain Pain intensity Pain management Parietal Lobe Participant Patients Pattern Phenotype Play Positioning Attribute Prefrontal Cortex Privatization Process Psychological Factors Psychophysics Psychophysiology Publishing Recording of previous events Recruitment Activity Regression Analysis Reporting Research Role Rotation Sampling Sensory Sex Characteristics Shapes Solid Statistical Data Interpretation Structure Techniques Testing Work base biomarker development chronic pain cingulate cortex cognitive control design ethnic difference experience imaging study inter-individual variation morphometry neuroimaging neuromechanism physical conditioning psychologic public health relevance response sex socioeconomics tractography treatment strategy volunteer

项目摘要

DESCRIPTION (provided by applicant): Both acute and chronic pain are associated with an incalculable toll in human suffering and present a significant economic problem. One of the major challenges in treating pain arises from the tremendous inter- individual variation in subjective reports of pain. Individuals with similar injuries will frequently report vastly differet experiences of pain. Such individual differences often result in inadequate treatment due to concerns about the validity or veracity of subjective reports of pain. Despite the profound clinica significance of individual differences in pain, remarkably little is known about the basic brain mechanisms that support such differences. Portions of this inter-individual variation in subjective reports of pain may be due to physical factors such as brain connectivity. Other components arise from psychological disposition and may involve factors such as cognitive control, impulsivity, depression, and anxiety. Finally, demographic variables such as sex and ethnicity may also substantially contribute to individual differences in pain sensitivity. Surprisingly littl is known about the brain mechanisms by which these factors influence the construction of the pain experience at the level of a single individual. Thus, the fundamental aim of the proposed research is to delineate the brain mechanisms that give rise to individual differences in pain sensitivity. We will acquire both functional and structural MRI data from a large number (392) of volunteers. Recruitment will be designed to obtain a true community sample in order to facilitate generalizability of findings. As such, this research will involve individuals of differing socio-economic levels, obese individuals, individuals with active depression and anxiety, as well as those in excellent physical and mental health. Participants will also undergo extensive sensory testing and psychological evaluation in order to fully characterize their pain phenotype. Multiple regression statistical analyses will be used to identify brain regions related to inter-individual differences in sensitivity in both structural and functional neuroimaging data. Techniques such as psychophysiological interaction analyses will be used to test hypotheses about the influence of functional connectivity on pain sensitivity. The identification of brain mechanisms that support individual differences in pain sensitivity will contribute substantially to our basic understandingof brain mechanisms of pain and will critically evaluate our existing notions that every individual processes nociceptive information in the same way. The results from the proposed studies will provide a solid rationale for the development of individualized pain treatment strategies.

描述（由申请人提供）：急性和慢性疼痛都与人类痛苦的不可估量的代价有关，并呈现出重大的经济问题。治疗疼痛的主要挑战之一来自于疼痛主观报告的巨大个体间差异。有类似伤害的个体通常会报告截然不同的疼痛体验。由于对疼痛主观报告的有效性或准确性的担忧，这种个体差异往往导致治疗不足。尽管疼痛的个体差异具有深远的临床意义，但人们对支持这种差异的基本大脑机制知之甚少。这种个体间的部分差异是主观的