Validating an automated nephrolithiasis registry as a community research tool

验证自动肾结石登记作为社区研究工具

• 批准号: 9566180
• 负责人: Tom Chi
• 金额: $ 13.07万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2020-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9566180
• 关键词: Address; Area; Award; Awareness; Clinical; Clinical Data; Clinical Research; Collaborations; Communication; Communities; Conflict (Psychology); Country; Critiques; Development; Discipline; Disease; Education; Ensure; Environment; Fostering; Funding; Future; Goals; Grant; Human Resources; Inflammation; Institutes; Institution; Interdisciplinary Study; International; Investigation; Leadership; Link; Location; Manuscripts; Measures; Medical center; Metals; Modeling; Nephrolithiasis; Obesity; Pathogenesis; Phase; Positioning Attribute; Principal Investigator; Progress Reports; Publications; Published Comment; Recording of previous events; Registries; Reporting; Research; Research Personnel; Resource Development; Resources; Science; Scientist; Series; Site; Time; Translational Research; Update; Urology; Validation; Visit; Work; clinical care; cohesion; collaborative environment; graduate student; interdisciplinary approach; lectures; meetings; member; novel; outreach; professor; programs; small molecule; success; symposium; synergism; tool; translational study; undergraduate student; urologic; web site; working group

SUMMARY/ABSTRACT: ADMINISTRATIVE CORE The overall goal of our research program is to develop an automated, integrated clinical registry as new resource supporting multi-institutional, high impact research within the urologic community. UCSF has been awarded P20 Center Scientific Project Grants to support nephrolithiasis research in the past. Its current Center is in its last year of funding, directed by Dr. Marshall Stoller. The central theme of that Center is to examine the link between small molecules, metals, and stone pathogenesis. The current P20 proposal is a Resource Development Project and was developed independently of activity sponsored by the previously awarded Center. It features a distinct resource development focus, separate leadership, and an independent scientific direction. Given the multifactorial causes for formation of stones and the association with multiple conditions including obesity and inflammation, there is an urgent need for an interdisciplinary approach to studying stone disease. We have assembled a group of researchers and collaborating centers with proven expertise in a wide range of disciplines. For the last 4 years, the core members of the research team have met regularly, at least twice a month, to discuss the research effort; an activity which has prepared us well to create an interdisciplinary center for a resource development. These meetings have created unique synergies between various members of the group and we are well positioned to make discoveries that will have a major impact on the field of nephrolithiasis. To validate the proposed Resource Development Project, 5 collaborating centers will participate in registry implementation and validation. The Administrative Core will be responsible for integrating our multiple collaborating sites and fostering an interdisciplinary approach by creating opportunities for regular presentations and discussions with investigators from multiple sites. We will strive to develop stronger interactions with the wider research community through our publications, national and international conferences, our lecture series and annual symposia. This will be accomplished by three aims: 1. Integrating interdisciplinary viewpoints to support stone disease research, 2. Ensuring efficient management of resources within the center, and 3. Outreach and developing interactions with the wider research community. We will be involved in educational outreach, embracing visiting professors and scientists from other institutes. For the UCSF P20 Resource Development Center an interactive website will be developed and updated on a regular basis. Together, these efforts will help create a unique, one of a kind, P20 center for stone disease providing a research resource to stimulate future investigators in pioneering novel areas of research and increased public awareness of the benefits of research.

摘要/摘要：行政核心 我们研究计划的总体目标是开发一个自动化的、集成的临床登记系统作为新的 支持泌尿外科界内多机构、高影响力研究的资源。加州大学旧金山分校已 过去曾获得 P20 中心科学项目资助以支持肾结石研究。目前的中心 这是由马歇尔·斯托勒博士指导的最后一年的资助。该中心的中心主题是研究 小分子、金属和结石发病机制之间的联系。目前的 P20 提案是一个资源 开发项目，独立于先前获奖者赞助的活动而开发 中心。它具有明确的资源开发重点、独立的领导机构和独立的科学机构。 方向。鉴于结石形成的多种因素以及与多种条件的关联 包括肥胖和炎症，迫切需要采用跨学科方法来研究结石 疾病。我们聚集了一批研究人员和合作中心，在广泛的领域拥有经过验证的专业知识 学科范围。过去4年来，研究团队的核心成员至少定期​​会面 每月两次，讨论研究工作；这项活动使我们做好了创建一个 跨学科资源开发中心。这些会议在双方之间创造了独特的协同效应 该小组的各个成员，我们都处于有利地位，能够做出将对以下领域产生重大影响的发现： 肾结石领域。为了验证拟议的资源开发项目，5 个合作中心 将参与注册管理机构的实施和验证。行政核心将负责 整合我们的多个合作网站并通过创造机会促进跨学科方法 与来自多个地点的研究人员进行定期演示和讨论。我们将努力发展 通过我们的国内和国际出版物与更广泛的研究界加强互动 会议、我们的讲座系列和年度研讨会。这将通过三个目标来实现： 1. 整合 跨学科观点支持结石病研究，2. 确保高效管理 中心内的资源，以及 3. 外展和发展与更广泛研究的互动 社区。我们将参与教育推广，欢迎来自世界各地的客座教授和科学家 其他机构。将为 UCSF P20 资源开发中心开发一个交互式网站， 定期更新。这些努力将共同帮助创建一个独特的、独一无二的 P20 中心 结石病提供了研究资源，以激励未来的研究人员开拓新领域 研究并提高公众对研究益处的认识。