2019 Polyamines GRS/GRC

2019 多胺 GRS/GRC

• 批准号: 9750998
• 负责人: Keith T. Wilson
• 金额: $ 1.2万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9750998
• 关键词: Academia; Aging; Amino Acids; Applications Grants; Area; Arginine; Asia; Authorization documentation; Bacterial Infections; Basic Science; Biological Models; Biology; Biotechnology; Budgets; Cancer Biology; Cell physiology; Chemopreventive Agent; Clinical; Clinical Trials; Collaborations; Communities; DL-alpha-Difluoromethylornithine; Development; Diabetes Mellitus; Digestive System Disorders; Discipline; Disease; Drosophila genus; Epigenetic Process; Europe; Fostering; Funding; Genetic Transcription; Goals; Host Defense; Hour; Human; Immune response; Immunology; Infection; Inflammation; Infusion procedures; International; Intervention; Ion Channel; Lead; Learning; Life; Link; Location; Malignant Neoplasms; Mammals; Metabolic Control; Metabolic Diseases; Metabolism; Names; National Institute of Allergy and Infectious Disease; National Institute of Diabetes and Digestive and Kidney Diseases; Nature; Neuroblastoma; North America; Organism; Outcome; Parasites; Parasitic infection; Participant; Pathway interactions; Pharmacologic Substance; Physicians; Plants; Play; Polyamines; Prevention; Prokaryotic Cells; Regulation; Request for Proposals; Research; Research Personnel; Role; Running; Scientist; South America; Students; Translational Research; Translations; Travel; United States National Institutes of Health; Vertebrates; Work; base; c new; carcinogenesis; career; career development; cost; data exchange; experience; graduate student; human disease; innovation; interest; meetings; member; microbiome; multidisciplinary; nervous system disorder; next generation; novel; pathogen; polycation; posters; programs; success; symposium; targeted treatment; translational impact; tumor

Project Summary. The Polyamines Gordon Research Conference (GRC) has run continuously since 1975, and provides a multidisciplinary forum that brings together leading polyamine researchers, as well as young and established investigators new to the field. The 2019 Polyamines GRC will be held at Waterville Valley Hotel in Waterville Valley, NH, from June 23-28, 2019. This GRC will have a broad focus on the role of polyamines in human diseases, with topic areas that include cancer biology, immunology/inflammation, host-pathogen interactions, digestive diseases, diabetes, neurologic disorders, and many new potential interventions. The meeting is unique in that it attracts a diverse array of top investigators assessing the control and roles of polyamines across a broad spectrum of model systems (prokaryotes, parasites, Drosophila, plants, vertebrates, and mammals). Polyamines are small, amino-acid-derived polycations found in all forms of life and play essential roles in many cellular processes, including transcription, translation, replication, metabolism, epigenetic control, and ion channel functions. The 2019 Polyamines GRC will emphasize targeting polyamine pathways in cancer and other diseases. It will showcase key new links between arginine metabolism and polyamines, and other metabolic control pathways that can then lead to alterations in host defense against pathogens and tumors, immune responses leading to inflammation, carcinogenesis, metabolic disorders, neurologic diseases, aging, and the microbiome. The Program has a strong mix of basic, translational, and clinical researchers. This GRC is attended by biologists, chemists, and physician-scientists, and includes investigators from academia, biotech, and pharmaceutical sectors. The diversity of scientific disciplines is unique among GRCs, is highly stimulating, and will emphasize new findings relating to upstream and downstream pathways, and diseases only recently linked to alterations in polyamine biology. We will bring the latest studies, new investigators to the field, and early career investigators to this forum. Of the 26 named speakers, 25 are new since the last GRC and 18 have never spoken at the GRC; 9 are early career scientists. We will choose 6 speakers from the Gordon Research Seminar (GRS) and the posters, which will add more new speakers. The specific aims seek to obtain funds to support 41 GRC and 16 GRS registrations, and travel costs for 16 GRC/GRS participants. The long-term objective is to enhance understanding of the interplay between polyamine metabolism and human diseases, and to develop promising young scientists into contributing members of the polyamine scientific community. Presentations by invited speakers will be 25-30 minutes, with a 10-minute discussion. The GRC will be held in conjunction with the 7th Polyamines GRS, providing graduate students and fellows with a student-run venue that fosters exchange of data and ideas. The GRS makes the GRC a richer experience, promoting participation of young scientists during the main conference. Interactions between GRS and GRC conferees facilitate sharing of new ideas and create new partnerships that will drive the field forward.

项目摘要。 多胺戈登研究会议（GRC）自1975年以来一直在不断运行，并提供了 多学科论坛汇集了领先的多胺研究人员，以及年轻的 新手的调查人员。 2019多胺GRC将在沃特维尔的沃特维尔谷酒店举行 新罕布什尔州谷，2019年6月23日至28日。该GRC将广泛关注多胺在人类中的作用 疾病，包括癌症生物学，免疫学/炎症，宿主病原体相互作用，包括疾病， 消化疾病，糖尿病，神经系统疾病和许多新的潜在干预措施。会议是 独特的是，它吸引了各种各样的顶级研究人员，以评估多胺的控制和作用 在广泛的模型系统（原核生物，寄生虫，果蝇，植物，脊椎动物和 哺乳动物）。多胺是在各种形式的生活中发现的小，氨基酸衍生的多阳离子，并发挥必不可少的 在许多细胞过程中的作用，包括转录，翻译，复制，代谢，表观遗传控制， 和离子通道功能。 2019多胺GRC将强调靶向癌症中的多胺途径 和其他疾病。它将展示精氨酸代谢和多胺之间的关键新链接，以及其他 代谢控制途径可能会导致宿主防御病原体和肿瘤的改变， 免疫反应导致炎症，致癌，代谢疾病，神经系统疾病，衰老， 和微生物组。该计划具有基本，转化和临床研究人员的强烈结合。这个GRC 生物学家，化学家和医师科学家参加了会议，包括学术界的研究人员 生物技术和制药领域。科学学科的多样性在GRC中是独一无二的，很高 刺激，并将强调与上游和下游途径有关的新发现和疾病 直到最近才与多胺生物学的改变有关。我们将把最新的研究，新的研究人员带到 现场和早期职业调查员参加了这个论坛。自上次GRC以来，在26名扬声器中，有25位是新的 和18岁从未在GRC讲话； 9是早期的职业科学家。我们将从 戈登研究研讨会（GRS）和海报，这将增加更多的新演讲者。特定目的寻求 获得支持41 GRC和16 GRS注册的资金，并为16个GRC/GRS参与者提供旅行费用。 长期目标是增强对多胺代谢和 人类疾病，并将有前途的年轻科学家发展为多胺成员 科学界。受邀演讲者的演讲将为25-30分钟，讨论10分钟。 GRC将与第七多胺GRS一起举行，为研究生和研究员提供 借助学生经营的场地，可以促进数据和想法的交换。 GRS使GRC变得更丰富 经验，在主要会议期间促进年轻科学家的参与。 GRS之间的相互作用 GRC Conferees促进了共享新想法，并建立新的合作伙伴关系，以推动该领域的前进。