2019 Polyamines GRS/GRC

项目摘要。 多胺戈登研究会议（GRC）自1975年以来一直持续运行，并提供了一个 多学科论坛，汇集了领先的多胺研究人员，以及年轻和建立 调查人员新到外地。2019年多胺GRC将在沃特维尔的沃特维尔山谷酒店举行 Valley，NH，2019年6月23日至28日本研究报告将广泛关注多胺在人体内的作用， 疾病，主题领域包括癌症生物学，免疫学/炎症，宿主-病原体相互作用， 消化系统疾病、糖尿病、神经系统疾病和许多新的潜在干预措施。这次会议是 独特之处在于它吸引了各种各样的顶级研究人员评估多胺的控制和作用 在广泛的模型系统（原核生物，寄生虫，果蝇，植物，脊椎动物， 哺乳动物）。多胺是小的，氨基酸衍生的聚阳离子在所有形式的生命和发挥必不可少的 在许多细胞过程中的作用，包括转录，翻译，复制，代谢，表观遗传控制， 和离子通道功能。2019年多胺GRC将强调靶向癌症中的多胺通路 和其他疾病。它将展示精氨酸代谢和多胺之间的关键新联系， 代谢控制途径可导致宿主对病原体和肿瘤的防御发生改变， 导致炎症、致癌、代谢紊乱、神经系统疾病、衰老 和微生物组。该计划拥有基础，翻译和临床研究人员的强大组合。这个GRC 生物学家、化学家和医学科学家参加，包括学术界的研究人员， 生物技术和制药行业。科学学科的多样性在GRCs中是独一无二的， 刺激，并将强调有关上游和下游途径，和疾病的新发现， 只是最近才与多胺生物学的改变联系起来。我们将带来最新的研究，新的调查人员， 现场，和早期的职业调查员到这个论坛。在26位命名的演讲者中，有25位是自上次GRC以来的新演讲者 18人从未在GRC发言; 9人是早期职业科学家。我们将选出6位演讲者， 戈登研究研讨会（GRS）和海报，这将增加更多的新发言人。具体目标是寻求 获得资金，以支持41个GRC和16个GRS注册，以及16个GRC/GRS参与者的差旅费。 长期目标是加强对多胺代谢和 人类疾病，并培养有前途的年轻科学家成为多胺的贡献成员 科学界。受邀演讲者的演讲时间为25-30分钟，其中有10分钟的讨论。 GRC将与第七届多胺GRS一起举行，为研究生和研究员提供 拥有一个由学生管理的场地，促进数据和想法的交流。GRS使GRC更丰富 经验，促进青年科学家参加主要会议。GRS之间的相互作用 和GRC与会者促进了新思想的分享，并建立了新的伙伴关系，这将推动该领域的发展。

Project Summary. The Polyamines Gordon Research Conference (GRC) has run continuously since 1975, and provides a multidisciplinary forum that brings together leading polyamine researchers, as well as young and established investigators new to the field. The 2019 Polyamines GRC will be held at Waterville Valley Hotel in Waterville Valley, NH, from June 23-28, 2019. This GRC will have a broad focus on the role of polyamines in human diseases, with topic areas that include cancer biology, immunology/inflammation, host-pathogen interactions, digestive diseases, diabetes, neurologic disorders, and many new potential interventions. The meeting is unique in that it attracts a diverse array of top investigators assessing the control and roles of polyamines across a broad spectrum of model systems (prokaryotes, parasites, Drosophila, plants, vertebrates, and mammals). Polyamines are small, amino-acid-derived polycations found in all forms of life and play essential roles in many cellular processes, including transcription, translation, replication, metabolism, epigenetic control, and ion channel functions. The 2019 Polyamines GRC will emphasize targeting polyamine pathways in cancer and other diseases. It will showcase key new links between arginine metabolism and polyamines, and other metabolic control pathways that can then lead to alterations in host defense against pathogens and tumors, immune responses leading to inflammation, carcinogenesis, metabolic disorders, neurologic diseases, aging, and the microbiome. The Program has a strong mix of basic, translational, and clinical researchers. This GRC is attended by biologists, chemists, and physician-scientists, and includes investigators from academia, biotech, and pharmaceutical sectors. The diversity of scientific disciplines is unique among GRCs, is highly stimulating, and will emphasize new findings relating to upstream and downstream pathways, and diseases only recently linked to alterations in polyamine biology. We will bring the latest studies, new investigators to the field, and early career investigators to this forum. Of the 26 named speakers, 25 are new since the last GRC and 18 have never spoken at the GRC; 9 are early career scientists. We will choose 6 speakers from the Gordon Research Seminar (GRS) and the posters, which will add more new speakers. The specific aims seek to obtain funds to support 41 GRC and 16 GRS registrations, and travel costs for 16 GRC/GRS participants. The long-term objective is to enhance understanding of the interplay between polyamine metabolism and human diseases, and to develop promising young scientists into contributing members of the polyamine scientific community. Presentations by invited speakers will be 25-30 minutes, with a 10-minute discussion. The GRC will be held in conjunction with the 7th Polyamines GRS, providing graduate students and fellows with a student-run venue that fosters exchange of data and ideas. The GRS makes the GRC a richer experience, promoting participation of young scientists during the main conference. Interactions between GRS and GRC conferees facilitate sharing of new ideas and create new partnerships that will drive the field forward.