ESSENTIAL AMINO ACIDS AND RESISTANCE EXERCISE IN AGING

必需氨基酸和抗衰老运动

• 批准号: 7719195
• 负责人: Blake B Rasmussen
• 金额: $ 0.13万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719195
• 关键词: Age; Aging; Amino Acids; Blood; Blood specimen; Computer Retrieval of Information on Scientific Projects Database; Elderly; Enrollment; Essential Amino Acids; Exercise; Funding; Grant; Growth; Hormones; Hour; Infection; Ingestion; Institution; Insulin; Intervention; Measures; Muscle; Muscle Proteins; Operative Surgical Procedures; Physical Dependence; Protein Biosynthesis; Rate; Research; Research Personnel; Resistance; Resources; Sampling; Signal Pathway; Signal Transduction; Source; Stress; Testosterone; Trauma; United States National Institutes of Health; Weight Lifting; base; improved; insight; male; mortality; older men; response; size; volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The loss of muscle mass leads to overall weakness, immobility and physical dependence, and can be responsible for an impaired response to stress, which is associated with higher mortality rates during infection, surgery, and trauma. Amino acids and weight lifting can both increase muscle size. It has been shown that muscle growth post-exercise is less in the elderly as compared to young volunteers. However, there have been no studies that have examined the combined effect of amino acids and resistance exercise. We hypothesize that amino acid ingestion following a bout of weight lifting exercise will improve short-term muscle growth in older men. The specific aims are to determine if 20 grams of essential amino acids ingested one hour following a bout of weight lifting exercise will stimulate short-term muscle growth in older men to the same extent as seen in the young. Six healthy young and older male volunteers will be enrolled. One hour following the exercise session each subject will receive 20 grams of essential amino acids. We will then assess changes in blood amino acid content, hormone changes such as insulin and testosterone from the blood samples. Each muscle sample will be used to measure muscle protein synthesis and to assess changes in cell signaling pathways the control protein synthesis. These studies will provide insight into why muscle loss is occurring with age and will then help us to develop scientifically-based interventions for improving muscle size.

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 肌肉质量的损失导致整体虚弱，不动和身体依赖，并可能导致对压力的反应受损，这与感染，手术和创伤期间的死亡率较高有关。 氨基酸和举重都可以增加肌肉的大小。 研究表明，与年轻志愿者相比，老年人运动后的肌肉生长较少。 然而，目前还没有研究表明，氨基酸和阻力运动的联合作用。 我们假设，在一轮举重运动后摄入氨基酸将改善老年男性的短期肌肉生长。 具体目标是确定在一次举重运动后一小时摄入20克必需氨基酸是否会刺激老年男性的短期肌肉生长，其程度与年轻人相同。 将招募6名健康的年轻和老年男性志愿者。运动后一小时，每名受试者将接受20克必需氨基酸。 然后，我们将评估血液氨基酸含量的变化，激素的变化，如胰岛素和睾酮从血液样本。 每份肌肉样本将用于测量肌肉蛋白质合成，并评估控制蛋白质合成的细胞信号传导途径的变化。 这些研究将深入了解为什么肌肉损失会随着年龄的增长而发生，然后将帮助我们开发以科学为基础的干预措施来改善肌肉大小。