Georgia Regents University Women's Reproductive Health Research Career Development Plan

佐治亚摄政大学妇女生殖健康研究职业发展计划

• 批准号: 9751091
• 负责人: Sharad A. Ghamande
• 金额: $ 4.8万
• 依托单位: AUGUSTA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-18 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9751091
• 关键词: Advisory Committees; Area; Arts; Clinical; Clinical Research; Collaborations; Committee Members; Communities; Competence; Complement; Custom; Development Plans; Discipline of obstetrics; Effectiveness; Enrollment; Environment; Funding; Future; Goals; Grant; Gynecology; Individual; Investigation; Measures; Mentors; Minority-Serving Institution; Morehouse School of Medicine; NCI Scholars Program; Outcome; Physicians; Process; Program Development; Program Evaluation; Recommendation; Records; Reproductive Health; Research; Research Personnel; Research Training; Resources; Scientist; Time; Training; Underrepresented Groups; Universities; Woman; Women' s Health; Work; base; career; career development; career life balance; expectation; experience; improved; interest; member; programs; prospective; recruit; responsible research conduct; role model; satisfaction; skill acquisition; success; virtual

 DESCRIPTION (provided by applicant): The overall objective of the Georgia Regents University (GRU) Women's Reproductive Health Research (WRHR) proposed career development program is to develop independent OB/GYN physician-researchers in basic, translational and/or clinical areas related to women's reproductive health. Institutional commitment to do so is extremely strong at GRU. There exists a robust research and training environment for each type of investigation. Scholars will be appointed, based on recommendations of an Advisory Committee, from a pool of candidates (local and national) who have demonstrated interest and prior experience in research. Members of underrepresented groups will be recruited proactively, in part through direct collaboration with the Department of Obstetrics and Gynecology at Morehouse School of Medicine, a historical minority-serving institution. Training of Scholars will be individualized based on their past experiences and competences. Two individuals will be enrolled at any one time, with the expectation that a total of four Scholars will be trained during the five year funding period. The proposed PI and Research Director are well experienced in research, training and administration, and will be complemented by a Recruitment Director and a Program Evaluation Director. Mentors will be experienced investigators with training track records who have research programs that are broadly relevant to women's reproductive health. These investigators will be complemented by a wide range of contemporary, sophisticated clinical and research resources. There will be six training aims:1) Prepare each Scholar for a career as a physician-scientist by providing customized didactic training and seminars; 2) Support the professional skill development of each individual Scholar, with the goal of helping him/her work more efficiently, such that they can maintain appropriate work-life balance, thereby improving overall satisfaction and success in their careers; 3) Provide each Scholar with a dynamic mentored research experience, relevant to his/her long-term research interests; 4) Train each Scholar in the art of grantsmanship; 5) Arrange networking opportunities (virtual and actual) for each Scholar, so that they become integrated within the women's health research community, connected with established investigators who can serve as prospective role models, career coaches, and/or collaborators; and 6) Educate each Scholar in the responsible conduct of research. Annual evaluation of the program will include objective analysis of both process and outcome of the Scholars, and the Program. Advisory Committee members will provide oversight and also assess programmatic effectiveness. Scholars will complete their training when they have demonstrably reached research independence, objectively measured by such criteria as ability to compete successfully for independent grant support. Scholars will be tracked after leaving the program. Overall, the training is expected to contribute substantively to expand the nation's capacity for future conduct of women's health research.

 描述(由申请人提供)：佐治亚州摄政大学(GRU)女性生殖健康研究(WRHR)拟议的职业发展计划的总体目标是在与女性生殖健康相关的基础、翻译和/或临床领域培养独立的妇产科医生-研究人员。在GRU，这样做的机构承诺非常坚定。每种类型的调查都有一个健全的研究和培训环境。学者将根据咨询委员会的建议，从对研究表现出兴趣和先前研究经验的候选人(当地和本国)中任命。代表不足的群体的成员将被主动招募，部分方式是通过与莫尔豪斯医学院妇产科的直接合作，莫尔豪斯医学院是一家历史上为少数群体服务的机构。学者培训将根据他们过去的经验和能力进行个性化培训。任何时候都将招收两名学生，预计在五年资助期内将总共培训四名奖学金获得者。拟议的PI和研究主任在研究、培训和管理方面经验丰富，并将由一名征聘主任和一名方案评价主任予以补充。导师将是有培训记录的经验丰富的调查人员，他们拥有与妇女生殖健康广泛相关的研究计划。这些研究人员将得到广泛的当代、复杂的临床和研究资源的补充。将有六个培训目标：1)通过提供定制的教学培训和研讨会，为每位学者作为内科科学家的职业生涯做好准备；2)支持每位学者的专业技能发展，目的是帮助他们更有效地工作，使他们能够保持适当的工作与生活平衡，从而提高总体满意度和事业成功；3)为每位学者提供与其长期研究兴趣相关的动态指导研究经验；4)培训每位学者的赠款艺术；5)为每个学者安排网络机会(虚拟的和实际的)，使他们融入妇女健康研究社区，与可以作为未来榜样、职业教练和/或合作者的知名研究人员联系起来；以及6)教育每个学者负责任地进行研究。该计划的年度评估将包括对学者计划的过程和结果的客观分析，以及该计划。咨询委员会成员将提供监督，并评估方案的有效性。学者将在他们明显达到研究独立时完成他们的培训，客观地衡量他们是否有能力成功地竞争独立的拨款资助。学者将在离开该项目后被跟踪。总体而言，预计培训将对扩大国家未来开展妇女健康研究的能力做出实质性贡献。

项目成果

Anti-HER-2 therapy following severe trastuzumab-induced cardiac toxicity.

• DOI: 10.1016/j.gendis.2017.07.007
• 发表时间: 2017-09
• 期刊: Genes & diseases
• 影响因子: 6.8
• 作者: Sadek I;Keaton M;Maihle NJ;Tang SC
• 通讯作者: Tang SC

High Glucose-Mediated STAT3 Activation in Endometrial Cancer Is Inhibited by Metformin: Therapeutic Implications for Endometrial Cancer.

二甲双胍对子宫内膜癌的高葡萄糖介导的STAT3激活抑制：对子宫内膜癌的治疗意义。

• DOI: 10.1371/journal.pone.0170318
• 发表时间: 2017
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Wallbillich JJ;Josyula S;Saini U;Zingarelli RA;Dorayappan KD;Riley MK;Wanner RA;Cohn DE;Selvendiran K
• 通讯作者: Selvendiran K