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Substance Abuse Treatment Development and Clinical Research Mentoring

药物滥用治疗开发和临床研究指导

基本信息

批准号：
9751262
负责人：
Frances Rudnick Levin
金额：
$ 17.39万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-08-01 至 2022-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9751262
关键词：
Abstinence Acute Address Adult Alcohol or Other Drugs use Alcohols Ambulatory Care Amphetamines Area Award Behavior Therapy Behavioral trial Cannabis Clinical Clinical Investigator Clinical Research Clinical Trials Cocaine Cocaine Dependence Collaborations Communities Comorbidity Controlled Clinical Trials Crack Cocaine Data Set Development Development Plans Disease Dopamine Double-blind trial Drug Use Disorder Ensure Faculty Funding Future Glutamates Goals Grant Guanfacine Heterogeneity Human Individual Inpatients Integrative Therapy Investigation K-Series Research Career Programs Ketamine Knowledge Laboratories Laboratory Finding Medical Students Mentored Patient-Oriented Research Career Development Award Mentors Mentorship Mid-Career Clinical Scientist Award (K24)Mindfulness Training Morbidity - disease rate Naltrexone Opioid Opioid user Outpatients Oxytocin Paper Participant Patients Pharmaceutical Preparations Pharmacotherapy Phase Physicians Placebos Prediction of Response to Therapy Prevention therapy Principal Investigator Program Development Psychological reinforcement Public Health Publishing Randomized Relapse Research Research Personnel Research Project Grants Salts Self Administration Sequential Treatment Series Site Stress Substance Use Disorder Substance abuse problem Techniques Technology Testing Time Training Translational Research Vaccines Vasopressins Withdrawal Symptom Work addiction base cannabis withdrawal career career development clinical research site cocaine use computerized contingency management disorder later incidence prevention effective therapy experience improved innovation interest marijuana use disorder marijuana user mindfulness neuroimaging next generation novel opioid withdrawal patient oriented patient oriented research pre-doctoral programs public health relevance quetiapine research and development safety and feasibility skills substance abuse treatment substance abuser therapy development topiramate treatment strategy treatment trial volunteer

项目摘要

DESCRIPTION (provided by applicant): The overall aim of this K24 Mid-Career Investigator Award in Patient-Oriented Research is to allow Dr. Frances Levin to continue to expand her programmatic line of clinical research and mentoring. Two main objectives drive the investigator's work: 1) develop pharmacotherapies that consider the heterogeneity of substance abusers and 2) provide mentorship to junior clinical investigators. Although there has been intensive investigation of medications and vaccines to treatment cocaine dependence, effective treatments remain elusive. Substance abuse is often accompanied with additional psychiatric comorbidity yet empirically-based treatments are limited. Moreover, there has been minimal research evaluating pharmacotherapies for cannabis use disorders, despite its substantial morbidity. Primary activities for this competing renewal and prior K24-funded accomplishments include developing novel combined medication treatment strategies for cocaine and cannabis-dependent individuals, testing new innovative behavioral interventions combined with pharmacotherapies for cocaine and other addictive disorders, and ensuring that promising human laboratory findings are efficiently tested in the outpatient treatment setting. During the course of this competing renewal K24 award Dr. Levin will be Principal Investigator of a U54 (a converted P50), a multi-site U1 (a converted R01), an R01, and Principal Investigator of a T32 that targets the training of physicians. Additionally, she will serve as a co-investigator or co-investigator on several other RO1s/R21s with both junior and mid-career colleagues that extend her areas of interest. And she will serve as a mentor on several mentored K awards. The career development plan for this application will expand Dr. Levin's knowledge into the areas of technology-based treatments, neuroimaging techniques, and stress-induced paradigms to predict treatment response through synergistic collaborations with other investigators. The mentoring plan incorporates trainees at various levels of development: 1) pre- doctoral trainees (medical students); 2) postdoctoral trainees (psychiatric residents and fellows); and 3) junior faculty. An overarching career goal has been to mentor clinical investigators and advance knowledge in the substance abuse field through reciprocal collaborations with other investigators, often with individuals that Dr. Levin has mentored or is currently mentoring. Of great public concern is a dearth of adequately trained physician investigators interested in clinical substance abuse research careers. Through Dr. Levin's activities it is hoped that the treatment of substance abusers will improve, both through her research and collaborations with colleagues, and through her training of the next generation of clinical investigators.

描述（由申请人提供）：在以患者为导向的研究中，这个K24中期职业研究者奖的总体目标是让Frances Levin博士继续扩大她的临床研究和指导的项目线。两个主要目标驱动研究者的工作：1）开发药物治疗，考虑物质滥用者的异质性和2）提供指导，以初级临床研究者。尽管对治疗可卡因依赖的药物和疫苗进行了深入的研究，但有效的治疗方法仍然难以捉摸。药物滥用往往伴随着额外的精神科合并症，但基于药物的治疗有限。此外，尽管大麻使用障碍的发病率很高，但评估大麻使用障碍药物疗法的研究却很少。这种竞争性更新和先前K24资助成就的主要活动包括为可卡因和大麻依赖者开发新型联合药物治疗策略，测试新的创新行为干预措施与可卡因和其他成瘾性疾病的药物治疗相结合，并确保有希望的人类实验室研究结果在门诊治疗环境中得到有效测试。在K24竞争性续约期间，Levin博士将担任U 54（转换的P50）、多中心U1（转换的R 01）和R 01的主要研究者，以及针对医生培训的T32的主要研究者。此外，她将担任其他几个RO 1/R21的共同研究者或共同研究者，与初级和中级职业同事一起扩展她的兴趣领域。她将担任几个指导K奖的导师。该应用程序的职业发展计划将扩大莱文博士的知识到基于技术的治疗，神经成像技术和压力诱导的范例领域，通过与其他研究人员的协同合作来预测治疗反应。指导计划包括不同发展水平的学员：（1）博士前学员（医科学生）;（2）博士后学员（精神科住院医生和研究员）;（3）初级教员。一个总体的职业目标是指导临床研究者，并通过与其他研究者的相互合作来推进药物滥用领域的知识，通常是与莱文博士指导过或目前正在指导的个人。公众非常关注的是缺乏对临床药物滥用研究事业感兴趣的训练有素的医生调查人员。通过莱文博士的活动，希望通过她的研究和与同事的合作，以及通过她对下一代临床研究人员的培训，改善对药物滥用者的治疗。

项目成果

期刊论文数量（33）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Psychometric properties of the Barkley Deficits in Executive Functioning Scale: A Spanish-Language Version in a community sample of puerto rican adults.

巴克利执行功能缺陷量表的心理测量特性：波多黎各成年人社区样本的西班牙语版本。

DOI：
10.1037/pas0000171
发表时间：
2016
期刊：
Psychological assessment
影响因子：
3.6
作者：
Vélez-Pastrana,MaríaC;González,RafaelA;RodríguezCardona,Javier;PurcellBaerga,Paloma;AliceaRodríguez,Ángel;Levin,FrancesR
通讯作者：
Levin,FrancesR

Corrigendum to "Developing an opioid use disorder treatment cascade: A review of quality measures" [Journal of Substance Abuse Treatment 91 (2018) 57-68].

“开发阿片类药物使用障碍治疗级联：质量措施审查”的勘误表 [Journal of Substance Abuse Treatment 91 (2018) 57-68]。

DOI：
10.1016/j.jsat.2018.06.015
发表时间：
2018
期刊：
Journal of substance abuse treatment
影响因子：
3.9
作者：
Williams,ArthurRobin;Nunes,EdwardV;Bisaga,Adam;Pincus,HaroldA;Johnson,KimberlyA;Campbell,AimeeN;Remien,RobertH;Crystal,Stephen;Friedmann,PeterD;Levin,FrancesR;Olfson,Mark
通讯作者：
Olfson,Mark

Variability in the prevalence of adult ADHD in treatment seeking substance use disorder patients: results from an international multi-center study exploring DSM-IV and DSM-5 criteria.

DOI：
10.1016/j.drugalcdep.2013.09.026
发表时间：
2014-01-01
期刊：
Drug and alcohol dependence
影响因子：
4.2
作者：
van de Glind G;Konstenius M;Koeter MWJ;van Emmerik-van Oortmerssen K;Carpentier PJ;Kaye S;Degenhardt L;Skutle A;Franck J;Bu ET;Moggi F;Dom G;Verspreet S;Demetrovics Z;Kapitány-Fövény M;Fatséas M;Auriacombe M;Schillinger A;Møller M;Johnson B;Faraone SV;Ramos-Quiroga JA;Casas M;Allsop S;Carruthers S;Schoevers RA;Wallhed S;Barta C;Alleman P;IASP Research Group;Levin FR;van den Brink W
通讯作者：
van den Brink W

Cocaine self-administration disrupted by the N-methyl-D-aspartate receptor antagonist ketamine: a randomized, crossover trial.