Remote Methods to Biochemically Verify Smoking Status
生化验证吸烟状况的远程方法
基本信息
- 批准号:9884111
- 负责人:
- 金额:$ 24.46万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-01-01 至 2021-12-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdultAirAndroidBiochemicalBiological AssayCarbon MonoxideCellular PhoneClinical TrialsCollectionCommunitiesConduct Clinical TrialsConsentCotinineDataData CollectionDatabasesEnhancement TechnologyEnrollmentEnsureEthnic OriginFaceFinancial compensationFunding AgencyFutureGoldGrantHealth TechnologyHumanInfrastructureInterventionLeadMeasurementMethodologyMethodsMonitorMulti-Institutional Clinical TrialOutcomeOutcomes ResearchParticipantPatient Self-ReportPersonsPopulationRaceRandomizedReadingResearchResearch MethodologyResearch PersonnelSalivaSamplingSampling StudiesSecureSignal TransductionSiteSmokerSmokingSmoking BehaviorSmoking Cessation InterventionSmoking StatusSocioeconomic StatusSubgroupSystemTechnologyTestingText MessagingTimeTranslatingTreatment EfficacyTubeUnited States National Institutes of HealthVisitarmbasebehavioral/social sciencecostcost effectivefeasibility trialhandheld mobile deviceimprovedineffective therapieslow socioeconomic statusmHealthmethod developmentprogramsrecruitruralitysexsmoking cessationstemtoolusabilityweb site
项目摘要
ABSTRACT
NCI has nearly 50 ongoing grants to develop and test remotely delivered, technology-based smoking cessation
interventions (e.g., apps, websites, text messaging). Remote cessation trials face one key methodological
limitation that undermines rigor: the need for biochemical verification of smoking status to accurately assess
intervention efficacy. Funding agencies are now strongly encouraging, if not requiring, biochemical verification
of smoking in all cessation trials regardless of whether the intervention is delivered in-person or remotely.
Incorporation of biochemical indicators of smoking status is critically important as inaccurate assessment of
smoking status may lead to dissemination of ineffective treatments and stagnant rates of population-level
cessation. Remote collection of expired-air carbon monoxide (CO) is a non-invasive approach that can be used
to verify smoking status. Remote CO offers the potential to inform episodic assessment of smoking (e.g., at 1,
3, or 6 months) as is typically done for clinical trial endpoints. Beyond clinical trials, remote CO offers the potential
to enhance human-lab methods by providing ecological granular assessment of day-to-day fluctuations in
smoking. However, extant trials that have implemented remote methods to assess CO have utilized CO monitors
that would be cost-prohibitive ($700-$1,200) to include in large-scale remote trials. Smartphone-enabled CO
monitors have recently become available and could dramatically improve the feasibility of remote CO collection.
Such monitors are available at substantially lower cost (~$72) than traditional monitors, can be used with any
iOS- or Android-compatible mobile device, and detect continuous CO concentrations of 0-100 parts per million.
Although these new monitors expand the methodologic potential to capture CO remotely, several issues must
first be resolved. Most critically, CO collection via smartphone-enabled monitor must be: 1) integrated in real-
time with other research outcomes, 2) valid when compared to gold-standard approaches for biochemical
verification, and 3) feasible as applied both to granular and episodic data collection. We herein propose to
develop and refine an integrated system through which a smartphone-enabled CO monitor (iCO™ Smokerlyzer)
is paired with secure online data capture via REDCap. This system will 1) initiate an iCO™ reading, 2) video
record the participant providing a CO reading, 3) translate the iCO™’s raw signal into a CO level, and 4) save
the CO level to a REDCap database integrated with other assessments. Subsequently, we will examine: a)
validity of the remote CO data capture system as compared to gold-standard methods for biochemical verification
and b) compliance with remote CO monitoring as applied both to episodic and granular data collection. This
project will develop and validate a tool that could fill the gap for a low-cost, feasible method to biochemically
verify smoking status within the context of NIH’s growing portfolio of remote and/or technology-enhanced
cessation treatments and has clear potential to improve the rigor of remote assessment of smoking behavior.
摘要
NCI有近50个正在进行的赠款,以开发和测试远程交付,基于技术的戒烟
干预(例如,应用程序、网站、文本消息)。远程戒烟试验面临一个关键的方法
破坏严谨性的限制:需要对吸烟状态进行生化验证,以准确评估
干预效果资助机构现在强烈鼓励,如果不是要求,生化验证
在所有戒烟试验中,无论干预是面对面还是远程进行。
纳入吸烟状况的生化指标是至关重要的,因为不准确的评估
吸烟状况可能导致无效治疗的传播和人口水平的停滞率
停止远程收集净化空气中的一氧化碳(CO)是一种非侵入性方法,
检查吸烟状况。远程CO提供了告知吸烟的情景评估的可能性(例如,在1处,
3个月或6个月),如通常针对临床试验终点所做的那样。除了临床试验,远程CO还提供了
通过提供日常波动的生态颗粒评估来增强人类实验室方法,
smoking.然而,已经实施远程方法来评估CO的现有试验已经利用CO监测器
将其纳入大规模远程审判的成本太高(700至1 200美元)。支持智能手机的CO
监测器最近已经变得可用,并且可以显著地提高远程CO收集的可行性。
这种显示器的价格比传统显示器低得多(约72美元),可以与任何
iOS或Android兼容的移动终端,并检测0-100 ppm的连续CO浓度。
虽然这些新的监测器扩展了远程捕获CO的方法潜力,但仍存在一些问题,
首先要解决。最关键的是,通过智能手机功能的监测器收集CO必须:1)集成在真实的-
与其他研究成果的时间,2)与生化的黄金标准方法相比有效
验证,以及3)适用于粒度和情景数据收集的可行性。我们在此提议,
开发和完善一个集成系统,通过该系统,智能手机支持的CO监测器(iCO™ Smokerlyzer)
与通过REDCap进行的安全在线数据采集相结合。该系统将1)启动iCO™阅读,2)视频
记录提供CO阅读的参与者,3)将iCO™的原始信号转换为CO水平,以及4)保存
将国家办事处一级纳入与其他评估相结合的REDCap数据库。接下来,我们将研究:a)
远程CO数据采集系统与生化验证金标准方法相比的有效性
和B)符合应用于偶发和颗粒数据收集的远程CO监测。这
项目将开发和验证一种工具,可以填补差距的低成本,可行的方法,以生物化学
在NIH不断增长的远程和/或技术增强的组合的背景下,
戒烟治疗,并有明显的潜力,以提高吸烟行为的远程评估的严格性。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jennifer Renee Dahne其他文献
Jennifer Renee Dahne的其他文献
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{{ truncateString('Jennifer Renee Dahne', 18)}}的其他基金
Hybrid Type 1 Effectiveness-Implementation Trial of a Proactive Smoking Cessation Electronic Visit for Scalable Delivery via Primary Care
主动戒烟电子就诊的混合 1 型有效性实施试验,通过初级保健进行可扩展交付
- 批准号:
10365698 - 财政年份:2022
- 资助金额:
$ 24.46万 - 项目类别:
Addressing Rural Cancer Disparities via Proactive Smoking Cessation Treatment within Primary Care: A Hybrid Type 1 Effectiveness-Implementation Trial of a Scalable Smoking Cessation Electronic Visit
通过初级保健中的主动戒烟治疗解决农村癌症差异:可扩展戒烟电子就诊的 1 型混合有效性实施试验
- 批准号:
10701074 - 财政年份:2022
- 资助金额:
$ 24.46万 - 项目类别:
Hybrid Type 1 Effectiveness-Implementation Trial of a Proactive Smoking Cessation Electronic Visit for Scalable Delivery via Primary Care
主动戒烟电子就诊的混合 1 型有效性实施试验,通过初级保健进行可扩展交付
- 批准号:
10552585 - 财政年份:2022
- 资助金额:
$ 24.46万 - 项目类别:
Addressing Rural Cancer Disparities via Proactive Smoking Cessation Treatment within Primary Care: A Hybrid Type 1 Effectiveness-Implementation Trial of a Scalable Smoking Cessation Electronic Visit
通过初级保健中的主动戒烟治疗解决农村癌症差异:可扩展戒烟电子就诊的 1 型混合有效性实施试验
- 批准号:
10552185 - 财政年份:2022
- 资助金额:
$ 24.46万 - 项目类别:
Development and Evaluation of a Brief Behavioral Activation Mobile Application for Nicotine Vaping Cessation Among Adolescent Primary Care Patients
针对青少年初级保健患者戒烟尼古丁的简短行为激活移动应用程序的开发和评估
- 批准号:
10250714 - 财政年份:2021
- 资助金额:
$ 24.46万 - 项目类别:
Development and Testing of a Depression-Specific Behavioral Activation Mobile App Paired with Nicotine Replacement Therapy Sampling for Smoking Cessation Treatment Via Primary Care
开发和测试抑郁症特异性行为激活移动应用程序,并结合尼古丁替代疗法采样,通过初级保健进行戒烟治疗
- 批准号:
10364683 - 财政年份:2018
- 资助金额:
$ 24.46万 - 项目类别:
Development and Testing of a Depression-Specific Behavioral Activation Mobile App Paired with Nicotine Replacement Therapy Sampling for Smoking Cessation Treatment Via Primary Care
开发和测试抑郁症特异性行为激活移动应用程序,并结合尼古丁替代疗法采样,通过初级保健进行戒烟治疗
- 批准号:
10112873 - 财政年份:2018
- 资助金额:
$ 24.46万 - 项目类别:
Development and testing of a behavioral activation mobile therapy for elevated depressive symptoms
针对抑郁症状加重的行为激活移动疗法的开发和测试
- 批准号:
10341195 - 财政年份:2015
- 资助金额:
$ 24.46万 - 项目类别:
Development and testing of a behavioral activation mobile therapy for elevated depressive symptoms
针对抑郁症状加重的行为激活移动疗法的开发和测试
- 批准号:
10006356 - 财政年份:2015
- 资助金额:
$ 24.46万 - 项目类别:
Development and testing of a behavioral activation mobile therapy for elevated depressive symptoms
针对抑郁症状加重的行为激活移动疗法的开发和测试
- 批准号:
10116480 - 财政年份:2015
- 资助金额:
$ 24.46万 - 项目类别:
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