Joint Biology Consortium Resource-based Center

联合生物学联盟资源中心

• 批准号: 9753918
• 负责人: Peter A Nigrovic
• 金额: $ 87.6万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-11 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9753918
• 关键词: Adult; American; Antibodies; Arthritis; Award; Basophils; Bioinformatics; Biology; Blood; Boston; CRISPR/Cas technology; Cell model; Cells; Child; Childhood; Clinic; Collaborations; Collection; Communication; Communities; Computerized Medical Record; Consent; Country; Data; Data Analyses; Dendritic Cells; Development; Ensure; Environment; Fostering; Generations; Genotype; Grant; Health; Healthcare; Heart; Hospitals; Human; Immunology; In Vitro; Individual; Inflammatory Arthritis; Infrastructure; Institutes; Institution; Joints; Lead; Leadership; Leukocytes; Logistics; Medical Genetics; Mentors; Methodology; Modeling; Mus; Online Systems; Osteoclasts; Patients; Pediatric Hospitals; Positioning Attribute; Pre-Clinical Model; Program Evaluation; Rare Earth Metals; Research; Research Personnel; Resources; Review Committee; Rheumatology; Sampling; Seasons; Services; Sorting - Cell Movement; Specimen; Stream; System; Techniques; Technology; Time; Tissues; Translational Research; Visit; Woman; Work; analytical tool; base; biobank; cohort; college; data management; design; droplet sequencing; eosinophil; in vivo; innovation; interest; mast cell; meetings; member; monocyte; neutrophil; next generation; novel; novel strategies; operation; patient population; preclinical study; professor; programs; protocol development; recruit; service delivery; single-cell RNA sequencing; success; synergism; tool; transcriptome sequencing; translational scientist; web portal

PROJECT SUMMARY/ABSTRACT - Overall Breaking down barriers to translational research is the key to finding new approaches to inflammatory arthritis in adults and children. We therefore propose the Joint Biology Consortium (JBC), a shared infrastructure based at the Brigham and Women's Hospital, Boston Children's Hospital, and the Broad Institute to accelerate the work of an arthritis-focused Research Community at 17 research centers in the US and abroad. Three Cores designed around the shared needs of JBC members will enhance the efficiency of existing studies, facilitate innovation, and foster junior investigators. 1. The Administrative Core is the organizational heart of the JBC, coordinating operations and cultivating the scientific potential of the JBC research network. The JBC Synergy Meeting promotes scientific interchange and collaboration, while the JBC Web Portal facilitates communication and service delivery. The JBC Enrichment Program, incorporating innovations from award-winning mentors, supports JBC Young Investigators via grant aims review, a novel mentoring program, and microgrants to enable utilization of JBC core service. 2. The Human Biosamples Core provides “one stop shopping” for adult and pediatric biospecimens essential to arthritis research. Web-based searches and targeted in-clinic recruitment will transform multiple distinct resources at BWH and Children's into a unified pipeline for biospecimens and associated clinical and genetic data. 3. The Cellular Systems Core provides resource- and expertise-intensive tools for arthritis research. Key services include centralized human sample processing, CyTOF, single-cell and low-input RNA-seq, and an innovative HoxB8 technology core for generation and CRISPR/Cas9 manipulation of pre-clinical model cells, including neutrophils, monocytes, and osteoclasts. Spearheaded by committed arthritis researchers Director Dr. Peter Nigrovic and Associate Director Dr. Elizabeth Karlson, the JBC will spur innovation within an inclusive and highly collaborative network of senior and junior investigators, leading the Joint Biology Consortium to become an engine of translational research in adult and pediatric arthritis.

项目摘要/摘要 - 总体 打破翻译研究的障碍是寻找新方法的炎症性关节炎的关键 在成人和儿童中。因此，我们提出了共享基础设施的联合生物联盟（JBC） 位于波士顿儿童医院的杨百翰和妇女医院和广大研究所加速 美国和国外17个研究中心以关节炎为重点的研究社区的工作。三 围绕JBC成员的共同需求而设计的核心将提高现有研究的效率， 促进创新，并培养初级调查员。 1。行政核心是JBC的组织心脏，协调操作和培养 JBC研究网络的科学潜力。 JBC协同会议促进了科学互换和 协作，而JBC Web门户网站促进了通信和服务交付。 JBC富集 计划结合了屡获殊荣的导师的创新，通过格兰特支持JBC年轻调查员 Aims Review是一种新颖的心理计划，以及可利用JBC核心服务的微电磁。 2。人类生物样本核心为成人和小儿生物测量提供“一站式购物” 关节炎研究。基于Web的搜索和针对性的临界招聘将改变多个不同的不同 BWH的资源和儿童的生物测量和相关临床和遗传的统一管道 数据。 3。细胞系统核心为关节炎研究提供了资源和专业的密集型工具。钥匙 服务包括集中的人类样品处理，细胞，单细胞和低输入RNA-seq，以及 创新的HOXB8技术核心用于生成和CRISPR/CAS9操纵前临床模型细胞的核心， 包括中性粒细胞，单核细胞和破骨细胞。 由承诺的关节炎研究人员主任Peter Nigrovic博士和副主任博士带头。 伊丽莎白·卡尔森（Elizabeth Karlson），JBC将刺激创新，包括高级高级合作网络 和初级研究人员，领导联合生物学财团成为转化研究的引擎 成人和小儿关节炎。