Comorbid Patterns with Alcohol Use Disorders

酒精使用障碍的共病模式

• 批准号: 9753699
• 负责人: Rosa M. Crum
• 金额: $ 32.24万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9753699
• 关键词: Adolescence; Adolescent; Adult; Age; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcohol or Other Drugs use; Alcoholism; Alcohols; Analgesics; Anxiety; Area; Attitude; Award; Clinical Research; Comorbidity; Conduct Disorder; Data; Development; Disease; Drug usage; Early Intervention; Employment; Epidemiology; Ethnic Origin; Family history of; Goals; Individual; Joints; Life; Longterm Follow-up; Marijuana; Marital Status; Mental Health; Modeling; Moods; NIH Program Announcements; Nicotine; Participant; Pattern; Pharmaceutical Preparations; Policies; Population; Population Study; Prevalence; Prevention; Preventive Intervention; Probability; Problem behavior; Race; Recovery; Sampling; Scoring Method; Selection Bias; Series; Severities; Social support; Subgroup; Substance Use Disorder; Surveys; Symptoms; Time; Tobacco; adverse childhood events; alcohol and other drug; alcohol comorbidity; alcohol epidemiology; alcohol involvement; alcohol related problem; alcohol use disorder; associated symptom; base; cohort; drinking; drinking behavior; epidemiologic data; follow-up; high risk; high risk population; improved; marijuana use; nonmedical use; population based; prescription opioid misuse; prospective; protective factors; public health relevance; reduce tobacco use; response; secondary analysis; sex; stimulant use; theories; treatment disparity; trend; young adult

 DESCRIPTION (provided by applicant): This revised R01 renewal application is in response to the Program Announcement PAR-14-338, entitled "Secondary Analysis of Existing Alcohol Epidemiology Data". The overall goals for this application are to assess patterns of alcohol involvement with comorbid non-alcohol substance use symptoms and disorders, specifically assessing transition patterns for these comorbid conditions, and for subgroups of the population. Although prior population-based and clinical studies have provided strong evidence for the comorbid occurrence of alcohol abuse and dependence with other substance use disorders, there has been relatively little assessment of patterns of comorbidity as users transition through different stages of involvement with alcohol and other substances. In prior decades, alcohol and tobacco were considered 'gateways', early antecedents to illegal substance use. However, recent surveillance trends indicate reduction in tobacco use, whereas marijuana use has risen, and non-medical use of prescription medications has taken a large upswing. Alcohol consumption in the past decade has also increased among adults. Given the changing attitudes and loosening of marijuana restrictions in the recent past in some areas of the US as well as greater apparent accessibility to non-medical use of prescription medications, there is a need to improve our understanding of patterns of alcohol and other drug use comorbidity. For this project renewal, we aim to assess the comorbid patterns involving alcohol and non-alcohol substances (nicotine, non-medical prescription opiod use, non- medical prescription stimulant use, and marijuana). Specifically we aim to 1) assess secular trends in alcohol comorbidity over the past 20 year period using data from the National Longitudinal Alcohol Epidemiologic Survey (NLAES) (1991-2), the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) wave 1 (2001-2), and the NESARC III (2012-3). We also aim 2) to further evaluate potential changes over time by assessing comorbid patterns of alcohol and drug involvement prospectively with latent class (LCA) and latent transition analysis (LTA) using the 3-year prospective data from the NESARC waves 1 and 2, and the National Comorbidity Survey (NCS) and its 10-year follow-up. 3) Based on concepts in problem behavior theory, we will also assess potential predictors of progression through stages of alcohol and drug involvement, as well as protective factors and those associated with recovery from more severe stages of comorbid alcohol and drug use. Our proposed analyses will examine comorbid patterns by sex, race-ethnicity and for the adolescence/young adulthood subgroups. 4) We aim to incorporate advanced statistical strategies in our analyses, and use propensity score methods with LTA models to improve our ability to draw causal inferences from the observational data. Alcohol and other drug use comorbidity is highly prevalent, and findings from the proposed project analyses should increase our understanding of these important comorbid associations and improve our ability to identify potential targets for prevention and early intervention.

 描述（由应用程序提供）：此修订后的R01更新应用程序响应于计划公告PAR-14-338，标题为“现有酒精流行病学数据的次要分析”。此应用的总体目标是评估酒精参与的模式，可合并非酒精药物使用症状和疾病，特别评估这些合并状况的过渡模式，以及对先前基于人群的和临床研究的亚组的过渡模式，但通过与其他相关性的疾病相关性的差异为其他差异提供了强有力的证据，这些证据不足参与酒精和其他物质的阶段。在过去的几十年中，酒精和烟草被认为是“门户”，即非法使用药物的早期先例。但是，最近的监视趋势表明使用烟草的使用量减少，而大麻的使用却增加了，而非医学使用处方药的使用也大大增加。在过去的十年中，成人的饮酒也有所增加。鉴于最近在美国某些地区的大麻限制不断变化和放松大麻限制，以及对非医学使用处方药的明显可访问性，因此有必要提高我们对酒精和其他药物使用模式合并症的理解。对于此项目续订，我们旨在评估涉及酒精和非酒精物质的合并症模式（尼古丁，非医学处方Oopod使用，非医学处方刺激剂使用和大麻）。特别是我们的目的是1）使用国家纵向酒精流行病学调查（NLAES）（1991-2）的数据评估过去20年中酒精合并症的世俗趋势（NESARC 1（NESARC）波1（2001-2）以及Nesarc III（Nesarc III（2012--3））。我们还针对2），通过使用NESARC WAVE 1和2的3年前瞻性数据以及国家合并症调查（NCS）及其10年的随访，使用潜在类别（LCA）（LCA）（LCA）（LCA）（LCA）和潜在过渡分析（LTA）进一步评估潜在的变化。 3）基于问题行为理论中的概念，我们还将通过酒精和药物参与阶段评估进展的潜在预测指标，以及保护因素以及与从更严重的酒精和药物使用阶段恢复相关的阶段。我们提出的分析将通过性别，种族种族和青少年/年轻成人亚组来检查合并模式。 4）我们的目标是将高级统计策略纳入分析中，并使用LTA模型使用承诺得分方法来提高我们从观察数据中汲取灾难性推断的能力。酒精和其他药物使用合并症非常普遍，拟议项目分析的发现应提高我们对这些重要合并症的理解，并提高我们确定预防和早期干预措施的潜在目标的能力。

项目成果

Baseline Insurance Status and Risk of Common Mental Disorders: A Propensity-Based Analysis of a Longitudinal U.S. Sample.

基线保险状况和常见精神疾病的风险：对美国纵向样本的基于倾向的分析。

• DOI: 10.1176/appi.ps.201400317
• 发表时间: 2016
• 期刊: Psychiatric services (Washington, D.C.)
• 作者: Sareen,Jitender;Wang,Yunqiao;Mota,Natalie;Henriksen,ChristineA;Bolton,James;Lix,LisaM;Mojtabai,Ramin;Bienvenu,OJoseph;Crum,RosaM;Afifi,TracieO
• 通讯作者: Afifi,TracieO

Comorbid Alcohol Dependence and Anxiety Disorders: A National Survey.

共病酒精依赖和焦虑症：全国调查。

• DOI: 10.1080/15504263.2013.835164
• 发表时间: 2013
• 期刊: Journal of dual diagnosis
• 影响因子: 2.2
• 作者: Pacek,LaurenR;Storr,CarlaL;Mojtabai,Ramin;Green,KerryM;LaFlair,LareinaN;Alvanzo,AnikaAH;Cullen,BernadetteA;Crum,RosaM
• 通讯作者: Crum,RosaM

The Association of Alcohol Use Disorders with Suicidal Ideation and Suicide Attempts in a Population-Based Sample with Mood Symptoms.

在具有情绪症状的人群样本中，酒精使用障碍与自杀意念和自杀企图的关联。

• DOI: 10.1080/13811118.2015.1004489
• 发表时间: 2016
• 期刊: Archives of suicide research : official journal of the International Academy for Suicide Research
• 作者: Sung,Yoon-kyu;LaFlair,LareinaN;Mojtabai,Ramin;Lee,Li-Ching;Spivak,Stanislav;Crum,RosaM
• 通讯作者: Crum,RosaM

Stressful life events and transitions in problematic alcohol use involvement among US adults.

美国成年人的压力生活事件和酒精使用问题的转变。

• DOI: 10.1080/10826084.2021.1975748
• 发表时间: 2021
• 期刊: Substance use & misuse
• 影响因子: 2
• 作者: Storr,CarlaL;Reboussin,BethA;Green,KerryM;Mojtabai,Ramin;Susukida,Ryoko;Young,AndreaS;Cullen,BernadetteA;Alvanzo,AnikaAH;Crum,RosaM
• 通讯作者: Crum,RosaM

Does self-medication predict the persistence or rather the recurrence of alcohol dependence?--reply.

自我药疗是否可以预测酒精依赖的持续存在或复发？--回复。

• DOI: 10.1001/jamapsychiatry.2013.3521
• 发表时间: 2014
• 期刊: JAMA psychiatry
• 影响因子: 25.8
• 作者: Crum,RosaM;Mojtabai,Ramin;Sareen,Jitender
• 通讯作者: Sareen,Jitender