Comorbid Patterns with Alcohol Use Disorders

酒精使用障碍的共病模式

• 批准号: 9753699
• 负责人: Rosa M. Crum
• 金额: $ 32.24万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9753699
• 关键词: Adolescence; Adolescent; Adult; Age; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcohol or Other Drugs use; Alcoholism; Alcohols; Analgesics; Anxiety; Area; Attitude; Award; Clinical Research; Comorbidity; Conduct Disorder; Data; Development; Disease; Drug usage; Early Intervention; Employment; Epidemiology; Ethnic Origin; Family history of; Goals; Individual; Joints; Life; Longterm Follow-up; Marijuana; Marital Status; Mental Health; Modeling; Moods; NIH Program Announcements; Nicotine; Participant; Pattern; Pharmaceutical Preparations; Policies; Population; Population Study; Prevalence; Prevention; Preventive Intervention; Probability; Problem behavior; Race; Recovery; Sampling; Scoring Method; Selection Bias; Series; Severities; Social support; Subgroup; Substance Use Disorder; Surveys; Symptoms; Time; Tobacco; adverse childhood events; alcohol and other drug; alcohol comorbidity; alcohol epidemiology; alcohol involvement; alcohol related problem; alcohol use disorder; associated symptom; base; cohort; drinking; drinking behavior; epidemiologic data; follow-up; high risk; high risk population; improved; marijuana use; nonmedical use; population based; prescription opioid misuse; prospective; protective factors; public health relevance; reduce tobacco use; response; secondary analysis; sex; stimulant use; theories; treatment disparity; trend; young adult

 DESCRIPTION (provided by applicant): This revised R01 renewal application is in response to the Program Announcement PAR-14-338, entitled "Secondary Analysis of Existing Alcohol Epidemiology Data". The overall goals for this application are to assess patterns of alcohol involvement with comorbid non-alcohol substance use symptoms and disorders, specifically assessing transition patterns for these comorbid conditions, and for subgroups of the population. Although prior population-based and clinical studies have provided strong evidence for the comorbid occurrence of alcohol abuse and dependence with other substance use disorders, there has been relatively little assessment of patterns of comorbidity as users transition through different stages of involvement with alcohol and other substances. In prior decades, alcohol and tobacco were considered 'gateways', early antecedents to illegal substance use. However, recent surveillance trends indicate reduction in tobacco use, whereas marijuana use has risen, and non-medical use of prescription medications has taken a large upswing. Alcohol consumption in the past decade has also increased among adults. Given the changing attitudes and loosening of marijuana restrictions in the recent past in some areas of the US as well as greater apparent accessibility to non-medical use of prescription medications, there is a need to improve our understanding of patterns of alcohol and other drug use comorbidity. For this project renewal, we aim to assess the comorbid patterns involving alcohol and non-alcohol substances (nicotine, non-medical prescription opiod use, non- medical prescription stimulant use, and marijuana). Specifically we aim to 1) assess secular trends in alcohol comorbidity over the past 20 year period using data from the National Longitudinal Alcohol Epidemiologic Survey (NLAES) (1991-2), the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) wave 1 (2001-2), and the NESARC III (2012-3). We also aim 2) to further evaluate potential changes over time by assessing comorbid patterns of alcohol and drug involvement prospectively with latent class (LCA) and latent transition analysis (LTA) using the 3-year prospective data from the NESARC waves 1 and 2, and the National Comorbidity Survey (NCS) and its 10-year follow-up. 3) Based on concepts in problem behavior theory, we will also assess potential predictors of progression through stages of alcohol and drug involvement, as well as protective factors and those associated with recovery from more severe stages of comorbid alcohol and drug use. Our proposed analyses will examine comorbid patterns by sex, race-ethnicity and for the adolescence/young adulthood subgroups. 4) We aim to incorporate advanced statistical strategies in our analyses, and use propensity score methods with LTA models to improve our ability to draw causal inferences from the observational data. Alcohol and other drug use comorbidity is highly prevalent, and findings from the proposed project analyses should increase our understanding of these important comorbid associations and improve our ability to identify potential targets for prevention and early intervention.



项目成果

Baseline Insurance Status and Risk of Common Mental Disorders: A Propensity-Based Analysis of a Longitudinal U.S. Sample.

基线保险状况和常见精神疾病的风险：对美国纵向样本的基于倾向的分析。

• DOI: 10.1176/appi.ps.201400317
• 发表时间: 2016
• 期刊: Psychiatric services (Washington, D.C.)
• 作者: Sareen,Jitender;Wang,Yunqiao;Mota,Natalie;Henriksen,ChristineA;Bolton,James;Lix,LisaM;Mojtabai,Ramin;Bienvenu,OJoseph;Crum,RosaM;Afifi,TracieO
• 通讯作者: Afifi,TracieO

Comorbid Alcohol Dependence and Anxiety Disorders: A National Survey.

共病酒精依赖和焦虑症：全国调查。

• DOI: 10.1080/15504263.2013.835164
• 发表时间: 2013
• 期刊: Journal of dual diagnosis
• 影响因子: 2.2
• 作者: Pacek,LaurenR;Storr,CarlaL;Mojtabai,Ramin;Green,KerryM;LaFlair,LareinaN;Alvanzo,AnikaAH;Cullen,BernadetteA;Crum,RosaM
• 通讯作者: Crum,RosaM

The Association of Alcohol Use Disorders with Suicidal Ideation and Suicide Attempts in a Population-Based Sample with Mood Symptoms.

在具有情绪症状的人群样本中，酒精使用障碍与自杀意念和自杀企图的关联。

• DOI: 10.1080/13811118.2015.1004489
• 发表时间: 2016
• 期刊: Archives of suicide research : official journal of the International Academy for Suicide Research
• 作者: Sung,Yoon-kyu;LaFlair,LareinaN;Mojtabai,Ramin;Lee,Li-Ching;Spivak,Stanislav;Crum,RosaM
• 通讯作者: Crum,RosaM

Does self-medication predict the persistence or rather the recurrence of alcohol dependence?--reply.

自我药疗是否可以预测酒精依赖的持续存在或复发？--回复。

• DOI: 10.1001/jamapsychiatry.2013.3521
• 发表时间: 2014
• 期刊: JAMA psychiatry
• 影响因子: 25.8
• 作者: Crum,RosaM;Mojtabai,Ramin;Sareen,Jitender
• 通讯作者: Sareen,Jitender

Stressful life events and transitions in problematic alcohol use involvement among US adults.

美国成年人的压力生活事件和酒精使用问题的转变。

• DOI: 10.1080/10826084.2021.1975748
• 发表时间: 2021
• 期刊: Substance use & misuse
• 影响因子: 2
• 作者: Storr,CarlaL;Reboussin,BethA;Green,KerryM;Mojtabai,Ramin;Susukida,Ryoko;Young,AndreaS;Cullen,BernadetteA;Alvanzo,AnikaAH;Crum,RosaM
• 通讯作者: Crum,RosaM