Comorbid Patterns with Alcohol Use Disorders

酒精使用障碍的共病模式

• 批准号: 8016018
• 负责人: Rosa M. Crum
• 金额: $ 36.61万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8016018
• 关键词: African American; Age; Age of Onset; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcohol or Other Drugs use; Alcohols; Anxiety; Anxiety Disorders; Behavior; Characteristics; Classification; Clinical; Clinical Research; Complex; Conduct Disorder; Country; DSM-IV; Data; Data Analyses; Data Set; Dependence; Development; Diagnosis; Diagnostic; Disease; Drug usage; Dysthymic Disorder; Epidemiology; Ethnic Origin; Event; Family; Female; Gender; Generalized Anxiety Disorder; Goals; Grant; Health; Health Insurance; Hispanics; Immigration; Incidence; Individual; Major Depressive Disorder; Manic; Mediator of activation protein; Mental Depression; Mental disorders; Methods; Mexican Americans; Mood Disorders; Moods; NIH Program Announcements; National origin; Not Hispanic or Latino; Outcome; Panic Disorder; Pathway interactions; Pattern; Personality; Population; Prevalence; Preventive Intervention; Probability; Psyche structure; Psychiatric Diagnosis; Race; Raspberries; Recording of previous events; Relative (related person); Reporting; Risk; Sample Size; Sampling; Sampling Studies; Selection Bias; Social Functioning; Social Phobia; Specific Phobia; Staging; Structure; Subgroup; Substance Use Disorder; Surveys; Survival Analysis; Symptoms; Syndrome; Techniques; Testing; Time; Tobacco use; United States; Variant; Woman; Work; addiction; alcohol epidemiology; alcohol involvement; alcohol related problem; alcohol use disorder; alcohol use initiation; disability; drinking; drinking behavior; ethnic minority population; high risk; hypomania; improved; information gathering; male; men; population based; prevent; racial and ethnic; response; sex; time use; trend

DESCRIPTION (provided by applicant): This revised R01 application is in response to the Program Announcement (PA-07-071) for "Secondary Analysis of Existing Alcohol Epidemiology Data". The overall goals for this application are to assess patterns of alcohol use disorders (AUD) with comorbid anxiety and mood conditions, to examine whether transition to alcohol dependence is altered by the presence of specific psychiatric disorders and symptoms, and if these patterns differ among gender and race-ethnicity subgroups. Although prior population-based and clinical studies have provided evidence for the comorbid occurrence of alcohol and with both mood and anxiety disorders, there have been little assessment of patterns of these co-occurrences, their relationship with transition to alcohol dependence, and whether these patterns differ for specific subgroups of the population. Using the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) dataset, we propose to 1) assess the comorbid prevalence, incidence and strength of association of AUD with anxiety symptoms and disorders (panic, social phobia, specific phobia and generalized anxiety disorder), and 2) mood symptoms and disorders (major depression, dysthymia, mania, and hypomania). In addition, using data from the National Longitudinal Alcohol Epidemiologic Survey (NLAES), 3) we aim to assess whether prevalence and comorbid trends of alcohol abuse and dependence with major depression have changed during the intervals between the NLAES (1991-92), and with wave 1 (2001-02) and wave 2 NESARC (2004-05). Using survival analyses, 4) we intend to assess whether age of (a) onset of AUD, (b) first symptom of excessive alcohol use, and (c) alcohol use initiation varies by presence and type of anxiety and mood condition. Using latent class analysis, 5) we also aim to examine the relationship of anxiety and mood disorders with patterns of excessive alcohol use symptoms, and using latent transition analyses to 6) assess patterns of transition to alcohol dependence. In addition, 7) for each specific aim, we will examine the bidirectional assessment of these associations. The proposed analyses should further our understanding of the comorbid patterns and relationships of alcohol, anxiety and mood symptoms and disorders. Assessment of patterns of these comorbid conditions potentially will improve our ability to identify high risk groups which may provide targets for early prevention and intervention efforts. Alcohol, mood and anxiety disorders together constitute some of the largest groups of mental and substance use conditions worldwide. Yet, the ability to examine the relationship of these conditions in a population-based sample (reducing potential selection biases), providing DSM-IV diagnostic criteria, within a sample large enough to assess potentially diverse associations among gender and race-ethnicity subgroups until now has been quite limited. The proposed analyses should fill in many gaps in our understanding of these co-occurring conditions. PUBLIC HEALTH RELEVANCE: Anxiety and mood problems are among the most common mental health disorders worldwide. These problems may increase the chance that other conditions occur such as addictions to alcohol. Using information gathered from one of the largest surveys to evaluate the presence of these symptoms among residents of the United States, we will study these relationships by different groups, in order to help understand if some individuals are more or less vulnerable to these conditions. This study aims to evaluate the complex relationships that may be occurring between mood, anxiety and drinking behavior with the hope that understanding these relationships better will help us identify improved methods for preventing and intervening with these conditions.

说明（由申请人提供）：此修订版 R01 申请是对“现有酒精流行病学数据的二次分析”计划公告 (PA-07-071) 的回应。该应用程序的总体目标是评估伴有焦虑和情绪状况的酒精使用障碍 (AUD) 模式，检查特定精神疾病和症状的存在是否会改变向酒精依赖的转变，以及这些模式在性别和种族亚组之间是否存在差异。尽管先前的基于人群的临床研究已经提供了酒精与情绪障碍和焦虑症共存的证据，但对这些共存的模式、它们与酒精依赖过渡的关系以及这些模式对于人口的特定亚组是否不同进行了很少的评估。使用全国酒精及相关疾病流行病学调查 (NESARC) 数据集，我们建议 1) 评估 AUD 与焦虑症状和障碍（恐慌、社交恐惧症、特定恐惧症和广泛性焦虑障碍）的共病患病率、发生率和关联强度，2) 情绪症状和障碍（重度抑郁、心境恶劣、躁狂和轻躁狂）。此外，利用全国纵向酒精流行病学调查 (NLAES) 的数据，3) 我们旨在评估在 NLAES (1991-92)、第 1 波 (2001-02) 和第 2 波 NESARC (2004-05) 之间的时间间隔内，酒精滥用和依赖与重度抑郁症的患病率和共病趋势是否发生了变化。通过生存分析，4) 我们打算评估 (a) AUD 发病年龄、(b) 过量饮酒的首发症状和 (c) 开始饮酒的年龄是否因焦虑和情绪状况的存在和类型而异。使用潜在类别分析，5) 我们还旨在检查焦虑和情绪障碍与过度饮酒症状模式的关系，并使用潜在转变分析来 6) 评估向酒精依赖转变的模式。此外，7）对于每个具体目标，我们将检查这些关联的双向评估。所提出的分析应进一步加深我们对酒精、焦虑和情绪症状及障碍的共病模式和关系的理解。对这些共病模式的评估可能会提高我们识别高风险人群的能力，这可能为早期预防和干预工作提供目标。酒精、情绪和焦虑障碍共同构成了全球最大的精神和物质使用状况。然而，到目前为止，在基于人群的样本中检查这些条件之间的关系（减少潜在的选择偏差）、提供 DSM-IV 诊断标准、在足够大的样本中评估性别和种族亚组之间潜在的多样化关联的能力还相当有限。所提出的分析应该填补我们对这些同时发生的条件的理解中的许多空白。公共卫生相关性：焦虑和情绪问题是全世界最常见的心理健康障碍之一。这些问题可能会增加其他情况发生的机会，例如酒精成瘾。利用从一项最大的调查中收集的信息来评估美国居民中这些症状的存在情况，我们将研究不同群体的这些关系，以帮助了解某些人是否或多或少容易受到这些状况的影响。这项研究旨在评估情绪、焦虑和饮酒行为之间可能发生的复杂关系，希望更好地理解这些关系将有助于我们找到预防和干预这些状况的改进方法。