ACTIVE Cognitive Training Trial: 20-Yr Follow-up of Functioning, Health, & Dementia

主动认知训练试验：20 年功能、健康、

• 批准号: 9754732
• 负责人: GEORGE W. REBOK
• 金额: $ 73.81万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9754732
• 关键词: Accounting; Acute; Address; Affect; Age; Age of Onset; Aging; Algorithms; Alzheimer' s Disease; Alzheimer' s disease related dementia; Ambulatory Care; Automobile Driving; Caring; Cause of Death; Cessation of life; Code; Cognition; Comorbidity; Data; Data Set; Dementia; Disease; Drug Prescriptions; Elderly; Event; Financial Hardship; Financial cost; Follow-Up Studies; Growth; Health; Health Care Costs; Health Care Visit; Health care facility; Healthcare; Home Care Services; Hospitalization; Impaired cognition; Incidence; Independent Living; Individual; Intervention; Life; Link; Maintenance; Medicaid; Medicaid eligibility; Medicare claim; Medicare/Medicaid; Memory; Mental Depression; Methods; Morbidity - disease rate; Outcome; Participant; Personal Satisfaction; Population; Prevention; Preventive care; Primary Health Care; Public Health; Public Policy; Randomized Clinical Trials; Records; Reporting; Resources; Sampling; Speed; Testing; Training; Visit; base; cognitive ability; cognitive benefits; cognitive training; combat; cost; daily functioning; depressive symptoms; disability; disability burden; evidence base; falls; follow-up; frailty; functional loss; health care service utilization; health service use; improved; indexing; innovation; instrumental activity of daily living; medical supply; mortality; novel; nursing home length of stay; physical conditioning; prevent; processing speed; randomized trial; therapy design; treatment effect; treatment group

Abstract The Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) study is the largest randomized clinical trial (N = 2802) to examine whether cognitive training enhanced both cognitive abilities and everyday functioning in normal older adults. Subjects trained on memory, reasoning, or processing speed performed significantly above controls at 5- and 10-year follow-ups. In addition, trained subjects reported less difficulty in performing IADL tasks at 10-year follow-up. Speed and reasoning training was associated with reduction in auto crashes and in driving cessation. Recent preliminary, but promising findings suggest an effect of training on incidence of Alzheimer's and related dementias. While these findings provide strong support for the benefits of cognitive training, the results focus on only short-term outcomes. This proposed 20-year follow-up would allow us to address questions highly relevant to health care and public policy that can only be addressed when the majority of the sample is deceased: Is training-related enhancement of cognition and everyday functioning associated with a long-term reduction in disability, loss of independence, and incident dementia in advanced old age and a reduction in associated financial costs? We propose to employ a wide range of linked data including: Medicare and Medicaid Claims, National Death Index, driving records, and credit reports. This study will assess the long-term impact and sustainability of the ACTIVE interventions on critical real life outcomes and related costs in advanced old age, including 1) Maintenance of independent functioning; 2) Physical health, disability, frailty, and mortality; 3) Incidence and duration of Alzheimer's and related dementias and depression.

摘要