Ethnicity and Nativity in Cancer - Latino & Asian Enclaves: The ENCLAVE Study

癌症中的种族和出生地 - 拉丁裔

• 批准号: 9885937
• 负责人: Sandi Leigh Pruitt
• 金额: $ 62.92万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9885937
• 关键词: Address; Adopted; American; Asian Americans; Asians; Attention; Automobile Driving; Breast; Businesses; California; Cancer Center; Cancer Control; Cause of Death; Cervix Uteri; Chinese People; Collaborations; Colorectal; Colorectal Cancer; Communities; Community Outreach; Country; Cuban; Data; Development; Diagnosis; Early Diagnosis; Ensure; Environment; Ethnic Origin; Ethnic group; Filipino; Florida; Funding; Future; Geography; Health; Health Promotion; Healthcare; Heterogeneity; Immigrant; Immigration; Incidence; Individual; Infrastructure; Intervention; Japanese Population; Joints; Koreans; Latina; Latino; Leadership; Linguistics; Link; Literature; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Measures; Methodology; Methods; Mexican; NCI-Designated Cancer Center; Neighborhoods; New Jersey; New York; Outcome; Patients; Pattern; Population; Population Growth; Procedures; Puerto Rican; Race; Research Personnel; Resources; Role; Science; South Asian; Stage at Diagnosis; Subgroup; Texas; Time; cancer health disparity; cancer prevention; cancer site; cancer type; data registry; design; disadvantaged population; disparity reduction; ethnic minority population; evidence base; experience; health disparity; improved; improved outcome; indexing; malignant breast neoplasm; mortality; multilevel analysis; neighborhood disadvantage; neoplasm registry; novel; population based; programs; racial and ethnic; residence; resilience; response; social; social capital; socioeconomic disadvantage; stressor; surveillance data

Project Summary/Abstract Cancer is the leading cause of death for Latinos and Asian Americans, who are among the fastest growing populations in the U.S. A large proportion of Latinos and Asian Americans live in ethnic enclaves—distinct neighborhoods with high concentrations of individuals of the same ethnic origin (“co-ethnic residents”) that are also characterized by recent immigration and linguistic isolation. The existing literature is mixed, with some studies showing that ethnic enclave residence (vs. non-enclave residence) and foreign- (vs. U.S.-) birthplace are associated with both better and/or worse outcomes across the cancer continuum. In this study, we will pool cancer registry data across five states (CA, FL, NJ, NY, TX) comprising the majority of Latinos and Asian Americans in the U.S. and link these data to contextual data characterizing the social, built and healthcare environments. We will determine whether and how ethnic enclave residence and foreign-birthplace are associated with three cancer outcomes (incidence, stage at diagnosis, survival) experienced by nine of the largest Latino and Asian ethnic groups (Cuban, Mexican, Puerto Rican, Chinese, Filipino, Japanese, Korean, South Asian, Vietnamese) diagnosed with three cancer types (breast, cervical, and colorectal cancers). Specifically, we aim to define and characterize ethnic enclaves, and examine cancer incidence by enclave residence (Aim 1) and determine independent and joint associations of ethnic enclave residence and nativity (foreign vs. US birthplace) on stage at diagnosis (Aim 2) as well as on mortality (Aim 3). With over 200,000 Latino and Asian American breast, colorectal, and cervical cancer cases, we will use multilevel models to understand the impact of ethnic enclaves on cancer outcomes for these understudied populations. In doing so, our study will accelerate discovery about the intersections between neighborhoods, ethnicity, nativity, and cancer and will improve data and methods used by central cancer registries across the U.S. Findings have potential to inform development of multilevel interventions to leverage enclave attributes that promote health and to address any barriers to reduce disparities and improve outcomes for our fastest growing ethnic minority and immigrant communities. We will disseminate our enclave measure and imputation procedures for missing data to the North American Association of Central Cancer Registries (NAACCR). In doing so, our methods will improve completeness of cancer registry data for surveillance of the growing Latino and Asian American populations. Our dissemination plan with collaboration from NAACCR leadership as well as the Offices of Community Outreach and Engagement at NCI Designated Cancer Centers in five states will ensure 1) methods are readily adopted by cancer registries and health disparities researchers across the nation; and 2) findings inform community-engaged efforts to address multilevel cancer disparities among Latino and Asian populations.

项目摘要/摘要 癌症是拉丁裔和亚裔美国人的主要死亡原因，他们是增长最快的人之一 美国的人口很大一部分拉丁裔和亚裔美国人生活在族裔飞地中 具有同一种族血统（“共同族裔居民”）的个人高度浓度的社区 也以最近的移民和语言隔离为特征。现有文献混合在一起，有些 研究表明，民族飞地居住（与非安克拉夫住所）和外国（vs.美国） 与整个癌症连续体的更好和/或更差的结果相关。在这项研究中，我们将汇总 五个州（CA，FL，NJ，NY，TX）的癌症注册表数据完成了大多数拉丁裔和亚洲 美国的美国人，并将这些数据链接到表征社会，建筑和医疗保健的上下文数据 环境。我们将确定是否以及如何以及如何以及如何 与三个癌症结局（发生率，诊断阶段，生存期）相关。 最大的拉丁裔和亚洲族裔（古巴，墨西哥，波多黎各，中国，菲律宾，菲律宾，日语，韩国人， 南亚，越南语）被诊断出患有三种癌症类型（乳腺癌，宫颈和结直肠癌）。 具体而言，我们旨在定义和表征民族飞地，并通过飞地检查癌症的发病率 居住（AIM 1）并确定民族飞地居住与耶稣降生的独立和共同关联 （外国与美国生日场所）在诊断（AIM 2）以及死亡率（AIM 3）上的舞台上。超过200,000 拉丁裔和亚裔美国乳房，结直肠癌和宫颈癌病例，我们将使用多级模型进行 了解这些知识人群的族裔飞地对癌症结果的影响。这样做， 我们的研究将加速有关社区，种族，诞生和 癌症，并将改善美国中央癌症注册机构使用的数据和方法 潜力为开发多层次干预措施的发展，以利用促进健康的飞地属性 并解决减少分布并改善我们成长最快的少数民族的结果的任何障碍 和移民社区。我们将传播我们的飞地测量和归纳程序的丢失程序 向北美中央癌症登记局（NAACCR）的数据。这样，我们的方法将 提高癌症注册表数据的完整性，以监视不断增长的拉丁裔和亚裔美国人 人群。我们与NAACCR领导和办公室合作的传播计划 在NCI指定的五个州指定癌症中心的社区外展和参与将确保1） 全国各地的癌症注册机构和健康差异很容易采用方法；和2） 调查结果为社区参与的努力提供了解决拉丁美洲和亚洲之间多级癌症分布的努力 人群。