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Dental Composites from Photoresponsive Addition-Fragmentation Filler Particles

由光响应加成-断裂填充颗粒制成的牙科复合材料

基本信息

批准号：
9886076
负责人：
Nick Bongiardina
金额：
$ 4.1万
依托单位：
UNIVERSITY OF COLORADO
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-05-01 至 2021-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9886076
关键词：
Address Amalgam Appearance Area Behavior Biocompatible Materials Biological Chemicals Chemistry Complex Composite Dental Resin Composite Resins Conflict (Psychology)Dental Dental Materials Development Esthetics Ethics Excision Failure Filler Formulation Fracture Free Radicals Goals Growth Hydrogen Bonding Industrialization Kinetics Knowledge Lead Learning Light Measurable Measures Mechanics Mentors Methacrylates Methodology Methods Modulus Network-based Organic Synthesis Performance Phase Plant Resins Polymers Property Reaction Relaxation Research Scheme Shapes Silicon Dioxide Stress Structure Sulfhydryl Compounds Surface System Tooth Fractures Tooth structure Training Viscosity base clinical implementation covalent bond crosslink dental resin design experience improved interfacial mechanical properties monomer nanocomposite nanoparticle particle photopolymerization polymerization premature prevent response restoration restoration placement restorative composite restorative dentistry restorative material stress reduction stress state

项目摘要

Project Summary. The proposed research involves the development of crosslinked organic filler particles and surface- modified inorganic fillers that are functionalized with radical addition-fragmentation chain transfer (AFT) moieties for stress reduction in dental restorative composites. Although there have been significant advances in the design of functionalized inorganic fillers and addition of AFT monomers to the resin (polymerizable) phase, stress development during polymerization is still a significant issue in dental restoratives that can lead microcracking of the composite, delamination from the tooth, or even tooth fracture. The design of functional, crosslinked AFT-based particles and subsequent implementation into classic dental resins will enable covalent bond rearrangement within the filler particle to relax stress as it develops. Similarly, incorporation of AFT moieties onto the surface of inorganic fillers is an additional method to introduce dynamic chemistry to the filler phase while maintaining the same mechanical properties of the resin. The purposed research will address stress concentration on the filler and filler/resin interface by taking advantage the Covalent Adaptable Networks (CANs) paradigm. This approach replaces the static bonds that normally exist in a crosslinked network with dynamic bonds that rearrange to a lower stress state in the presence of proper activating species. In the case of AFT, the activating species are free radicals, which are also the active species during the photopolymerization of the dimethacrylate based resins used in most dental restorative composites. The first aim is to develop AFT particles that reduce stress development both during polymerization and upon external loading of classic glassy systems, then implement these particles directly as an additive to standard dental resin formulations and study their effect on the stress behavior. Next, we will develop AFT organic/inorganic nanocomposite particles with functionalized silica nanoparticles to circumvent limitations such as resin viscosity and modulus of the composite. The second aim is to functionalize silica nanoparticles with AFT moieties to enable bond exchange only at the filler/matrix interface without maintaining the mechanical properties of the final composite. We will then incorporate the both the organic AFT particles and the functionalized to investigate possible synergistic effects of both particle types in a dental composite. To accomplish these goals, the purposed training plan will enable trainee to interact with mentors and learn from their technical and practical experience with dental materials. The selected mentoring committee has extensive experience with synthesis, characterization of polymeric dental materials, and clinical implementation, and industrial considerations. The trainee will receive relevant and meaningful training in research-oriented areas and conducting research both thoughtfully and ethically.

项目总结。