Clinical , Mechanical and Chemical Evaluation of Amalgam and ART Restorations

汞合金和ART修复体的临床,机械和化学评估

基本信息

项目摘要

DESCRIPTION (provided by applicant): Dental caries (tooth decay) remains a significant national and international health problem, especially in low- income and disadvantaged populations. Results of several clinical trials conducted outside the US (US studies have not been conducted) have suggested that glass ionomer cement (GIC) restorations used in a simplified and economic procedure known as atraumatic restorative treatment (ART) technique may be more successful than conventional dental treatments for large carious lesions with respect to increased restoration longevity and decreased caries recurrence. The reasons for the success of ART have not been clearly established, but it has been suggested that the GIC may interact with the caries affected tissue to restore a portion of its mineral content. Dental caries occurs when bacterial dental plaque combines with consumed, fermentable carbohydrates. This combination produces acids that penetrate and dissolves the tooth surfaces. GIC's are biocompatible materials having low technique sensitivity and release fluoride (F) which creates internal remineralization of a carious lesion. ART is an "atraumatic" technique as no drilling of teeth or anesthesia is required, thus making it advantageous in certain settings and situations. Amalgam is an alloy of mercury with another metal (silver) used traditionally by dentists to fill cavities in teeth. In Aim 1, we plan to conduct a prospective cohort study of initially 5 to 11 year-old children with at least one carious primary molar (1 to 3 surfaces cavitated) that has been restored with ART or amalgam. The children, patients at the Asian Health Services Dental Clinic in Oakland, CA and the CARECEN dental clinic in the primarily Hispanic Mission neighborhood of San Francisco, will receive initial dental assessments including pre-treatment radiographs, and treatment by staff dentists. Both clinics have agreed to participate and use both materials as part of their usual care. Patients that fit the child and tooth-level selection criteria will be recruited. Baseline clinical and radiographic evaluation of the ART and amalgam restorations, and 6-month and 12-month follow-up assessments (without radiographs) will be take place to assess clinical outcomes: a) caries recurrence, b) restoration retention, and c) restoration marginal integrity over time. In aims 2 and 3, analyses of the two restorative materials will be undertaken with restored teeth that naturally exfoliate during the study period. In Aim 2 we will examine the mechanical properties, microstructural characteristics of the restoration/tooth interfaces (Nanoindentation, and SEM-EDS) to identify changes induced in the tissues by the restorative materials and to provide insight to the mechanisms that could induce such changes. In Aim 3 we will evaluate the chemical changes of the restoration/tooth interfaces (RMS) to identify the presence of remineralization caused by the interaction of the dental materials (GIC and amalgam) with the dental tissues (enamel and dentin). A better understanding of the similarities and differences in the clinical, mechanical and chemical properties of these two materials when placed in primary teeth will help guide future recommendations for their use in the US. Public Health Relevance: This clinical translational observational study will allow us to evaluate the effectiveness of two dental restorative materials in two populations of high caries-risk children from lower socio-economic status households, many of whom rely on public assistance. One population is treated at the Asian Health Services Dental Clinic (AHSDC) in Oakland, California and the other at the Central American Resource Center (CARECEN) dental clinic in primarily Hispanic, Mission Neighborhood of San Francisco, California. This research will advance our understanding of the clinical outcomes of atraumatic restorative treatment (ART) vs. traditional amalgam techniques. ART has the advantage of being low cost, relatively easy to apply, especially to young children, and not requiring anesthesia and drilling of teeth. Additionally, the restored teeth will be collected after exfoliation to examine the remineralization process, and mechanical and chemical properties. If the results are favorable for ART with regard to restoration retention, marginal integrity, decreased caries recurrence, remineralization and other interactions with dental tissues, this type of treatment has the potential to impact dental practice, patient management policies, and public health.
描述(由申请人提供):龋齿(蛀牙)仍然是一个重大的国家和国际健康问题,特别是在低收入和弱势群体。在美国以外进行的几项临床试验(尚未进行美国研究)的结果表明,在称为无创伤修复治疗(ART)技术的简化和经济程序中使用的玻璃离子粘固粉(GIC)修复可能比传统牙科治疗更成功,用于大龋损,以延长修复寿命和减少龋齿复发。ART成功的原因尚未明确,但已表明GIC可能与龋齿影响的组织相互作用,以恢复其部分矿物质含量。当细菌性牙菌斑与消耗的可发酵碳水化合物结合时,龋齿发生。这种结合产生的酸渗透和溶解牙齿表面。GIC是生物相容性材料,具有低技术敏感性并释放氟化物(F),其产生龋损的内部再矿化。ART是一种“无创伤”技术,因为不需要钻孔或麻醉,因此在某些环境和情况下具有优势。汞齐合金是汞和另一种金属(银)的合金,传统上被牙医用来填充牙齿的空洞。在目标1中,我们计划对最初5至11岁的儿童进行前瞻性队列研究,这些儿童至少有一颗龋坏乳磨牙(1至3个表面成洞),已用ART或汞合金修复。这些儿童、加利福尼亚州奥克兰的亚洲健康服务牙科诊所和旧金山弗朗西斯科主要拉美裔使命社区的CARECEN牙科诊所的病人将接受初步的牙科评估,包括治疗前的X光片和牙医的治疗。两家诊所都同意参与并使用这两种材料作为他们日常护理的一部分。将招募符合儿童和牙齿水平选择标准的患者。将对ART和银汞合金修复进行基线临床和影像学评价,并进行6个月和12个月随访评估(无影像学检查),以评估临床结局:a)龋齿复发,B)修复体固位,以及c)随时间推移的修复体边缘完整性。在目标2和3中,将对两种修复材料进行分析,并对研究期间自然脱落的修复牙齿进行分析。在目标2中,我们将检查修复体/牙齿界面的机械性能和微观结构特征(纳米压痕和SEM-EDS),以确定修复材料在组织中引起的变化,并深入了解可能引起这种变化的机制。在目标3中,我们将评估修复体/牙齿界面(RMS)的化学变化,以确定牙科材料(GIC和汞合金)与牙科组织(牙釉质和牙本质)相互作用引起的矿化的存在。更好地了解这两种材料在乳牙中的临床、机械和化学性质的相似性和差异,将有助于指导其在美国的未来使用建议。 公共卫生相关性:这项临床转化观察性研究将使我们能够评估两种牙科修复材料在两个来自社会经济地位较低家庭的高龋齿风险儿童人群中的有效性,其中许多人依赖公共援助。一组人群在位于加州奥克兰的亚洲健康服务牙科诊所(AHSDC)接受治疗,另一组人群在主要位于西班牙裔的中美洲资源中心(CARECEN)牙科诊所接受治疗,该诊所位于加州弗朗西斯科的使命Neighborhood。这项研究将促进我们对非创伤性修复治疗(ART)与传统汞合金技术的临床结果的理解。ART的优点是成本低,相对容易应用,特别是对幼儿,并且不需要麻醉和钻孔。此外,将在脱落后收集修复的牙齿,以检查再矿化过程以及机械和化学性能。如果结果有利于ART修复保留,边缘完整性,减少龋齿复发,再矿化和其他与牙齿组织的相互作用,这种类型的治疗有可能影响牙科实践,患者管理政策和公共卫生。

项目成果

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Lilliam Marie Pinzon其他文献

Lilliam Marie Pinzon的其他文献

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{{ truncateString('Lilliam Marie Pinzon', 18)}}的其他基金

Clinical , Mechanical and Chemical Evaluation of Amalgam and ART Restorations
汞合金和ART修复体的临床,机械和化学评估
  • 批准号:
    8523830
  • 财政年份:
    2009
  • 资助金额:
    $ 12.73万
  • 项目类别:
Clinical , Mechanical and Chemical Evaluation of Amalgam and ART Restorations
汞合金和ART修复体的临床,机械和化学评估
  • 批准号:
    7938803
  • 财政年份:
    2009
  • 资助金额:
    $ 12.73万
  • 项目类别:
Clinical , Mechanical and Chemical Evaluation of Amalgam and ART Restorations
汞合金和ART修复体的临床,机械和化学评估
  • 批准号:
    8330669
  • 财政年份:
    2009
  • 资助金额:
    $ 12.73万
  • 项目类别:
Clinical , Mechanical and Chemical Evaluation of Amalgam and ART Restorations
汞合金和ART修复体的临床,机械和化学评估
  • 批准号:
    7769604
  • 财政年份:
    2009
  • 资助金额:
    $ 12.73万
  • 项目类别:

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