课题基金 / 基金详情

Steroselectivity of Synthetically Valuable Enzyme Catalysts

Steroselectivity of Synthetically Valuable Enzyme Catalysts
有合成价值的酶催化剂的立体选择性
批准号：
9884779
负责人：
KENDALL N HOUK
金额：
$28.97万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
项目状态：
已结题
起止时间：
2018-04-01 至 2022-02-28
来源：
https://reporter.nih.gov/project-details/9884779
关键词：
AcidsActive SitesAlcoholsAldehydesAminesAmino Acid SequenceAntibioticsBeta CarbolinesBiochemical ReactionBiologyChemicalsCollaborationsComplexComputational TechniqueComputing MethodologiesDiels Alder reactionDistalElementsEngineeringEnzymesFiltrationFree EnergyGoalsHot SpotIndustrializationIntuitionKetonesKineticsLaboratoriesLocationMethodsMutationOxidesPathway interactionsPharmacologic SubstancePhysical condensationPrincipal Component AnalysisProcessProductionProtein EngineeringProtocols documentationReactionReagentResearchResolutionSamplingSequence AlignmentStrictosidine synthaseSystemTestingTransaminasesanalogbasecatalystcombinatorialcomparativecycloadditiondecalindesignflexibilityimprovedmolecular dynamicsmutantnovelprogramsprotein foldingpyridine

项目摘要

项目成果

KENDALL N HOUK的其他基金

相似基金

相关文献

中文摘要
翻译
项目摘要 这项研究计划开发并应用最先进的计算方法来 了解酶催化剂对具有高合成价值的反应的立体选择性。 立体选择性的控制是有效合成的一个基本特征，而这 程序提供了对这些选择性的起源的解释，并以此为基础 预测立体选择性反应的新型酶催化剂。合作者测试这些 预测。这些都是合成有效药物的关键要素。 探员们。
英文摘要
Project Abstract This research program develops and applies state-of-the-art computational methods to understand stereoselectivities of enzyme catalysts for reactions of high synthetic value. The control of stereoselectivity is an essential feature of efficient synthesis, and this program provides explanations of the origins of these selectivities and builds on these to predict new enzyme catalysts for stereoselective reactions. Collaborators test these predictions. These are critical elements in the synthesis of effective pharmaceutical agents.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Bioorthogonal Cycloadditions
Bioorthogonal Cycloadditions
Mapping the Evolution of a Novel Enzyme by Experiment and Computation
Mapping the Evolution of a Novel Enzyme by Experiment and Computation
海外基金