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ORIGINS OF STEREO-SELECTIVE CATALYSIS BY ANTIBODIES

ORIGINS OF STEREO-SELECTIVE CATALYSIS BY ANTIBODIES
抗体立体选择性催化的起源
批准号：
7722326
负责人：
KENDALL N HOUK
金额：
$0.32万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
项目状态：
已结题
起止时间：
2008-05-01 至 2009-04-30
来源：
https://reporter.nih.gov/project-details/7722326
关键词：
AntibodiesAntibody Binding SitesCatalysisComputer Retrieval of Information on Scientific Projects DatabaseDockingFundingGoalsGrantInstitutionReactionResearchResearch PersonnelResearch Project GrantsResourcesSourceStructureUnited States National Institutes of Healthcatalystinsightquantum

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中文摘要
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英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Using Autodock and Autodock Toolkit (ADT) to study antibody catalysis. This involves quantum mechanically computed transition structures docked into antibody binding sites to obtain insights into stereoselective catalysis. The goal of this research project is to understand the mechanism by which antibody catalysts accelerate the reaction and induce stereoselectivity.
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Steroselectivity of Synthetically Valuable Enzyme Catalysts
Bioorthogonal Cycloadditions
Bioorthogonal Cycloadditions
Mapping the Evolution of a Novel Enzyme by Experiment and Computation
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