Time-of-Flight Mass Spectrometer for Synthesis Supporting Biomedical Research

描述(申请人提供)：生物医学研究的许多方面的进展在很大程度上取决于新的合成化合物和生物材料的发展。合成研究人员的一个关键工具是质谱学，这一要求的目的是提供必要的质谱学仪器，以促进新化合物和生物材料的发现。需要一台现代最先进的飞行时间(TOF)质谱仪及其适当的附件，用于对各种新的合成化合物进行快速分析。该系统将配备一个电喷雾(ESI)和大气压化学电离(APCI)源，一个用于引入精确质量测量的内部标准的入口，一个用于在需要时进行化学分离的快速高效液相系统，一个用于在适当情况下直接循环进样的计算机控制开关阀，一个自动取样器，以及开放访问软件。该仪器将是支持美国国立卫生研究院资助的8个项目的具体目标的重要组成部分，这些项目旨在加强对合成过程的了解，为生物医学研究创造新的材料和设备，并开发诊断和治疗试剂。拟议的飞行时间质谱仪系统将由加州大学洛杉矶分校分子仪器中心(MIC)支持和管理，该中心是一个校园范围的综合设施，旨在提高现有共享的、复杂的仪器设施对该机构更广泛的研究社区的可访问性。在校园核心设施中提供质谱仪将极大地促进一系列项目的进展，这些项目旨在创造新的分子，这些新分子将产生针对多种人类疾病的治疗和诊断方法。这项研究将影响一系列人类健康问题，包括各种细菌和病毒疾病、结核病、乳腺癌、激素难治性前列腺癌、心脏病、糖尿病和阿尔茨海默病。与公共健康相关：要求为校园范围的核心设施配备质谱仪，这将极大地促进旨在创造新分子的广泛项目的进展，这些新分子将产生针对多种人类疾病的治疗和诊断方法。这项研究将影响一系列人类健康问题，包括各种细菌和病毒疾病、结核病、乳腺癌、激素难治性前列腺癌、心脏病、糖尿病和阿尔茨海默病。

DESCRIPTION (provided by applicant): The progress of many aspects of biomedical research is critically dependent on the development of new synthetic compounds and biomaterials. A key tool for synthetic researchers is mass spectrometry and the aim of this request is to provide the necessary mass spectrometry instrumentation to enhance discovery of new compounds and biomaterials. A modern state-of-the-art time-of-flight (TOF) mass spectrometer with appropriate accessories for rapid analysis for a variety of new synthetic compounds is requested. This system will be equipped with a combination electrospray (ESI) and atmospheric pressure chemical ionization (APCI) source, an inlet for introduction of internal standard for exact mass measurements, a rapid HPLC system for chemical separations when needed, a computer-controlled switching valve for direct loop injection when appropriate, an autosampler, and open access software. This instrument will be a vital component to support the specific aims of over 8 NIH-funded projects that enhance the understanding of the synthetic process, create new materials and devices for biomedical research, and develop diagnostic and therapeutic agents. The proposed time-of-flight mass spectrometer system will be supported and administered by the UCLA Molecular Instrumentation Center (MIC), a campus-wide, integrated facility formed to enhance the accessibility of existing shared, sophisticated instrumentation facilities to the broader research community at the institution. The availability of a mass spectrometer in a campus core facility will greatly facilitate the progress of a wide range of projects designed to create new molecules that will produce therapeutics and diagnostic methods for a number of human diseases. The research will impact a range of human health issues, including various bacterial and viral diseases, tuberculosis, breast cancer, hormone refractory prostate cancer, heart disease, diabetes and Alzheimer's disease. PUBLIC HEALTH RELEVANCE: A mass spectrometer is requested for a campus-wide core facility, which will greatly facilitate the progress of a wide range of projects designed to create new molecules that will produce therapeutics and diagnostic methods for a number of human diseases. The research will impact a range of human health issues, including various bacterial and viral diseases, tuberculosis, breast cancer, hormone refractory prostate cancer, heart disease, diabetes and Alzheimer's disease.