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A Novel, Non-Cytotoxic, Epigenetic Therapeutic for Sickle Cell Disease

A Novel, Non-Cytotoxic, Epigenetic Therapeutic for Sickle Cell Disease
镰状细胞病的新型非细胞毒性表观遗传疗法
批准号：
9755493
负责人：
JOSEPH DESIMONE
金额：
$75.0万
依托单位：
DENOVOTHERAPIES, LLC
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
项目状态：
已结题
起止时间：
2017-04-24 至 2020-07-31
来源：
https://reporter.nih.gov/project-details/9755493
关键词：
AddressAdoptionAdverse eventBiological AvailabilityChemicalsChemistryClinicClinicalClinical ResearchClinical TrialsCoagulation ProcessConsumptionCytidine DeaminaseCytidine Deaminase InhibitorCytostaticsDNA Modification MethylasesDataDecitabineDiseaseDoseDrug CombinationsDysmyelopoietic SyndromesEffectivenessEnzymesEpigenetic ProcessErythrocytesFDA approvedFetal HemoglobinFunctional disorderGeneric DrugsGenesGoalsHemoglobinHemolysisHourHydrogenationIn VitroInterruptionIntestinesIon-Exchange Chromatography ProcedureLaboratory MarkersLifeLiverModelingModificationMorbidity - disease rateMovementMusMutateNational Heart, Lung, and Blood InstituteNational Institute of Diabetes and Digestive and Kidney DiseasesOralPapioPathway interactionsPatientsPharmaceutical PreparationsPharmacologic SubstancePharmacologyPharmacy facilityPhasePhase I Clinical TrialsPlacebosPlasmaPolymersPositioning AttributePowder dose formPrevalenceProcessProteinsRare DiseasesReactionRefractoryReportingRhodiumRiskS PhaseSafetySchemeSickle Cell AnemiaSickle HemoglobinSmall Business Innovation Research GrantSmall IntestinesStomachTabletsTetrahydrouridineTherapeuticTimeUnited States National Institutes of HealthUridinecatalystcommercializationcostcytotoxiccytotoxicitydrug developmentgamma Globinhydroxyureain uteroin vivomortalitynovelprocess optimizationreconstitution

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Improving HbF induction by inhibiting epigenetic target enzymes
Improving HbF induction by inhibiting epigenetic target enzymes
Chicago Comprehensive Sickle Cell Center: Basic & Translational Research Program
Chicago Comprehensive Sickle Cell Center: Basic & Translational Research Program
  • 批准号：
    7640595
  • 项目类别：
  • 资助金额：
    $182.36万
  • 财政年份：
    2008
  • 负责人：
    JOSEPH DESIMONE
  • 依托单位：
    UNIVERSITY OF ILLINOIS AT CHICAGO
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